Ke Jin
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View article: Clinical Value of Complement C3a, C5a, and sC5b-9 in Evaluating the Severity of Patients with Severe Fever with Thrombocytopenia Syndrome
Clinical Value of Complement C3a, C5a, and sC5b-9 in Evaluating the Severity of Patients with Severe Fever with Thrombocytopenia Syndrome Open
This study revealed abnormalities in complement components among patients with SFTS. C3a and sC5b-9 levels show promise as biomarkers for linking with disease severity and prognosis, potentially providing therapeutic targets for the manage…
View article: Allosteric Inhibitors of Cell-Cycle-Regulated Methyltransferase for Novel Antibiotic Development
Allosteric Inhibitors of Cell-Cycle-Regulated Methyltransferase for Novel Antibiotic Development Open
Cell-cycle-regulated methyltransferase (CcrM) plays a crucial role in regulating important cellular processes that are essential for proper cell division and growth; disruptions of these processes can attenuate the bacteria's viability. No…
View article: Proteome-wide Mendelian randomization identifies causal plasma proteins in prostate cancer development
Proteome-wide Mendelian randomization identifies causal plasma proteins in prostate cancer development Open
Our consistent results highlighted the important roles of plasma SMAD2 and CREB3L4 in the risk of prostate cancer. Further investigations on these proteins may reveal their potential in the prevention and treatment of prostate cancer.
View article: A Finite Sample Analysis of Distributional TD Learning with Linear Function Approximation
A Finite Sample Analysis of Distributional TD Learning with Linear Function Approximation Open
In this paper, we study the finite-sample statistical rates of distributional temporal difference (TD) learning with linear function approximation. The aim of distributional TD learning is to estimate the return distribution of a discounte…
View article: A Regularized Online Newton Method for Stochastic Convex Bandits with Linear Vanishing Noise
A Regularized Online Newton Method for Stochastic Convex Bandits with Linear Vanishing Noise Open
We study a stochastic convex bandit problem where the subgaussian noise parameter is assumed to decrease linearly as the learner selects actions closer and closer to the minimizer of the convex loss function. Accordingly, we propose a Regu…
View article: Heterogeneity of lymphoid cells in PBMCs in the acute phase of SFTS: single-cell transcriptome profiling
Heterogeneity of lymphoid cells in PBMCs in the acute phase of SFTS: single-cell transcriptome profiling Open
Severe fever with thrombocytopenia syndrome (SFTS), caused by Dabie bandavirus (DBV), triggers aberrant immune activation and cytokine storm, contributing to poor prognosis, yet its immune dysfunction mechanism remains unclear. Current tre…
View article: Impact of the obesity paradox on 28-day mortality in elderly patients critically ill with cardiogenic shock: a retrospective cohort study
Impact of the obesity paradox on 28-day mortality in elderly patients critically ill with cardiogenic shock: a retrospective cohort study Open
Background Previous studies have shown that the obesity paradox exists in cardiovascular disease (CVD), giving patients a survival advantage, but controversy remains as to whether it applies to patients with cardiogenic shock (CS), especia…
View article: Automating life science labs at the single-cell level through precise ultrasonic liquid sample ejection: PULSE
Automating life science labs at the single-cell level through precise ultrasonic liquid sample ejection: PULSE Open
Laboratory automation technologies have revolutionized biomedical research. However, the availability of automation solutions at the single-cell level remains scarce, primarily owing to the inherent challenges of handling cells with such s…
View article: Asymptotic Time-Uniform Inference for Parameters in Averaged Stochastic Approximation
Asymptotic Time-Uniform Inference for Parameters in Averaged Stochastic Approximation Open
We study time-uniform statistical inference for parameters in stochastic approximation (SA), which encompasses a bunch of applications in optimization and machine learning. To that end, we analyze the almost-sure convergence rates of the a…
View article: Effect of duration of ECMO application on prolonged mechanical ventilation after lung transplantation in patients with idiopathic pulmonary fibrosis
Effect of duration of ECMO application on prolonged mechanical ventilation after lung transplantation in patients with idiopathic pulmonary fibrosis Open
Background Lung transplantation is the optimal treatment choice, while extracorporeal membrane oxygenation (ECMO) provides cardiopulmonary support during the perioperative period of lung transplantation. Currently, there is no reported res…
View article: TRIM3 attenuates cytokine storm caused by Dabie bandavirus via promoting Toll-like receptor 3 degradation
TRIM3 attenuates cytokine storm caused by Dabie bandavirus via promoting Toll-like receptor 3 degradation Open
Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was caused by the Dabie bandavirus (DBV), and it has become a global public health threat. Cytokine storm is considered to be an important…
View article: Severe pneumonia with co-infection of H5N1 and SARS-CoV-2: a case report
Severe pneumonia with co-infection of H5N1 and SARS-CoV-2: a case report Open
Background H5N1 influenza is a cause of severe pneumonia. Co-infection with influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to poor prognosis in the epidemic of COVID-19. However, few studies have report…
View article: The dose–response relationship between smoking and the risk factor for invasive pulmonary aspergillosis in patients with severe fever with thrombocytopenia syndrome
The dose–response relationship between smoking and the risk factor for invasive pulmonary aspergillosis in patients with severe fever with thrombocytopenia syndrome Open
Objectives Invasive pulmonary aspergillosis (IPA) is common in immuno-compromised people, and a high incidence of IPA has been found in patients with severe fever with thrombocytopenia syndrome (SFTS). Our study aimed to determine the inde…
View article: A High Viral Load in Urine Correlates With Acute Kidney Injury and Poor Outcomes in Hospitalized Patients With Severe Fever With Thrombocytopenia Syndrome: A Noninvasive and Convenient Prognostic Marker
A High Viral Load in Urine Correlates With Acute Kidney Injury and Poor Outcomes in Hospitalized Patients With Severe Fever With Thrombocytopenia Syndrome: A Noninvasive and Convenient Prognostic Marker Open
Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with an extensive geographical distribution and high mortality rate. To date, the role of SFTS virus (SFTSV) in urine is still elusive. We aime…
View article: lncRNA‑miRNA‑mRNA network in female offspring born from obese dams
lncRNA‑miRNA‑mRNA network in female offspring born from obese dams Open
Maternal obesity is associated with disturbance of lipid metabolism and obesity in offspring; however, the pathogenesis is still unclear. The present study elucidated the role of potential lipid metabolism-associated long non-coding RNA (l…
View article: 4-Terminal Inorganic Perovskite/Organic Tandem Solar Cells Offer 22% Efficiency
4-Terminal Inorganic Perovskite/Organic Tandem Solar Cells Offer 22% Efficiency Open
After fast developing of single-junction perovskite solar cells and organic solar cells in the past 10 years, it is becoming harder and harder to improve their power conversion efficiencies. Tandem solar cells are receiving more and more a…
View article: Cyclophilin A causes severe fever with thrombocytopenia syndrome virus-induced cytokine storm by regulating mitogen-activated protein kinase pathway
Cyclophilin A causes severe fever with thrombocytopenia syndrome virus-induced cytokine storm by regulating mitogen-activated protein kinase pathway Open
Introduction Severe fever with thrombocytopenia syndrome (SFTS) has become a global threat to public health since its first report in China in 2009. However, the pathogenesis of SFTS virus (SFTSV) in humans remains unclear. Also, there are…
View article: Caspase-7 and acid sphingomyelinase: partner repairmans of gasdermin and perforin pores
Caspase-7 and acid sphingomyelinase: partner repairmans of gasdermin and perforin pores Open
Recently, a work published in Nature by Kengo Nozaki et al. revealed a novel mechanism for plasma membrane pores' repair mediated by caspase-7. 1In this work, they found caspase-7 facilitated Intestinal epithelial cell (IEC) extrusion and …
View article: Comparative and Phylogenetic Analysis of Complete Chloroplast Genomes in Leymus (Triticodae, Poaceae)
Comparative and Phylogenetic Analysis of Complete Chloroplast Genomes in Leymus (Triticodae, Poaceae) Open
Leymus is a perennial genus that belongs to the tribe Triticeae (Poaceae) which has an adaptive capacity to ecological conditions and strong resistance to cold, drought, and salinity. Most Leymus species are fine herbs that can be used for…