Claire McGinn
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View article: In depth characterisation of the proteome of MIS-C and post COVID-19 infection in children reveals inflammatory pathway activation and evidence of tissue damage
In depth characterisation of the proteome of MIS-C and post COVID-19 infection in children reveals inflammatory pathway activation and evidence of tissue damage Open
Background Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe complication that arises between two and six weeks after initial SARS-CoV-2 infection. The mechanisms underlying why only a subset of children develop th…
View article: PPA2-associated cardiac arrest survivor
PPA2-associated cardiac arrest survivor Open
Biallelic pathogenic variants in the inorganic pyrophosphatase 2 (PPA2) gene are a rare but established cause of sudden infant death, which may be precipitated by a pyrexial or viral illness. It has also been associated with sudden death s…
View article: Pericardial Effusion on CXR, an aide-memoir
Pericardial Effusion on CXR, an aide-memoir Open
Chest pain in children is a common presentation to the Emergency Department
View article: Sore knee – why and when to call a cardiologist
Sore knee – why and when to call a cardiologist Open
A young girl received a diagnosis of septic arthritis of the knee unresponsive to standard medical and surgical treatment. We report the patient’s clinical journey with clinical commentary throughout, underlying the importance of different…
View article: Paediatric heart failure – understanding the pathophysiology and the current role of cardiac biomarkers in clinical practice
Paediatric heart failure – understanding the pathophysiology and the current role of cardiac biomarkers in clinical practice Open
Introduction: Paediatric heart failure is a common clinical syndrome that may be experienced by children with congenital heart disease (CHD) and/or cardiomyopathy. It is characterised by clinical signs/symptoms which reflect the underlying…
View article: How to interpret cardiac biomarkers in children?
How to interpret cardiac biomarkers in children? Open
Cardiac biomarkers are used as first-line diagnostic tools in suspected myocardial injury and heart failure in adult patients. Their use in paediatric patients has been limited by variability caused by age, gender and the presence of an un…
View article: 675 Symptoms of SARS-CoV-2 infection in the UK paediatric population
675 Symptoms of SARS-CoV-2 infection in the UK paediatric population Open
Background During the first wave of the pandemic in 2020, Covid-19 symptoms of cough, fever and loss of taste/smell were identified in the adult population and aided diagnostic PCR testing. However, children with similar symptoms appeared …
View article: 701 How low is too low? Determining the incidence of symptomatic neonatal hyponatraemia secondary to maternal peripartum hyponatraemia- an unsolved problem
701 How low is too low? Determining the incidence of symptomatic neonatal hyponatraemia secondary to maternal peripartum hyponatraemia- an unsolved problem Open
Background In Northern Ireland the Guidelines and Audit implementation network produced guidance in 2017 advising that paediatricians should be informed when infants are born to mothers with a peripartum serum sodium <129mmol/L. However, t…
View article: 793 Predicting serious bacterial infections in infants aged 90 days or less
793 Predicting serious bacterial infections in infants aged 90 days or less Open
Background NICE sepsis guidelines advise febrile children aged ≤90 days are at higher risk of serious illness. Therefore, children undergo investigations and receive antibiotic therapy in these cases, despite limited data on actual number …
View article: Kinetics and seroprevalence of SARS-CoV-2 antibodies in children
Kinetics and seroprevalence of SARS-CoV-2 antibodies in children Open
View article: Secondary Attack Rate and Family Clustering of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children of Healthcare Workers With Confirmed Coronavirus Disease 2019 (COVID-19)
Secondary Attack Rate and Family Clustering of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children of Healthcare Workers With Confirmed Coronavirus Disease 2019 (COVID-19) Open
We measured serum SARS-CoV-2 antibodies in 215 children of healthcare workers to estimate secondary attack rates. Twenty-one families had a parent with confirmed COVID-19. There was strong evidence of family clustering (P < .001): 20/21…
View article: Seroprevalence of SARS-CoV-2 antibodies in children of United Kingdom healthcare workers: a prospective multicentre cohort study protocol
Seroprevalence of SARS-CoV-2 antibodies in children of United Kingdom healthcare workers: a prospective multicentre cohort study protocol Open
Background A novel coronavirus SARS-CoV-2 has been responsible for a worldwide pandemic. Children typically have very mild, or no, symptoms of infection. This makes estimations of seroprevalence in children difficult. Research is therefore…
View article: Seroprevalence of SARS-CoV-2 antibodies in children - A prospective multicentre cohort study
Seroprevalence of SARS-CoV-2 antibodies in children - A prospective multicentre cohort study Open
Background Studies based on molecular testing of oral/nasal swabs underestimate SARS-CoV-2 infection due to issues with test sensitivity and timing of testing. The objective of this study was to report the presence of SARS-CoV-2 antibodies…
View article: COVID-19 and SARS-CoV-2 Seropositivity in Children of Healthcare Workers in London
COVID-19 and SARS-CoV-2 Seropositivity in Children of Healthcare Workers in London Open
View article: Outcomes of abdominal myomectomy vs uterine fibroid embolization in morbidly obese women
Outcomes of abdominal myomectomy vs uterine fibroid embolization in morbidly obese women Open