Claire E. Stewart
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View article: Effects of resistance exercise, collagen ingestion and circulating oestrogen concentration on collagen synthesis in a female athlete: A case report
Effects of resistance exercise, collagen ingestion and circulating oestrogen concentration on collagen synthesis in a female athlete: A case report Open
We investigated the effects of resistance exercise (RE), hydrolysed collagen (HC) ingestion and circulating oestrogen concentration on collagen synthesis in a naturally menstruating female CrossFit athlete. In a double‐blind, randomised cr…
View article: Exercise on cytokine responses in males and females: Effect of leucine, HMB and BCAA
Exercise on cytokine responses in males and females: Effect of leucine, HMB and BCAA Open
Purpose To identify the effects of leucine, β-hydroxy β-methylbutyrate (HMB) and branched chain amino acid (BCAA) on post-exercise cytokine responses in females and males. Methods Males (n=53) and females (n=37) completed 100 drop jumps an…
View article: Modelling Skeletal Muscle Ageing and Repair In Vitro
Modelling Skeletal Muscle Ageing and Repair In Vitro Open
Healthy skeletal muscle can regenerate after ischaemic, mechanical, or toxin-induced injury, but ageing impairs that regeneration potential. This has been largely attributed to dysfunctional satellite cells and reduced myogenic capacity. U…
View article: The Effect of Carbohydrate Restriction on Lipids, Lipoproteins, and Nuclear Magnetic Resonance-Based Metabolites: CALIBER, a Randomised Parallel Trial
The Effect of Carbohydrate Restriction on Lipids, Lipoproteins, and Nuclear Magnetic Resonance-Based Metabolites: CALIBER, a Randomised Parallel Trial Open
Low-carbohydrate high-fat (LCHF) diets can be just as effective as high-carbohydrate, lower-fat (HCLF) diets for improving cardiovascular disease risk markers. Few studies have compared the effects of the UK HCLF dietary guidelines with an…
View article: Chlamydia trachomatis: Management and screening
Chlamydia trachomatis: Management and screening Open
C hlamydia trachomatis is the most common sexually transmitted infection worldwide. In up to 50% of men and 70% of women, infection is asymptomatic or minimally symptomatic and can easily be missed. Untreated infection can cause significan…
View article: Collagen supplementation augments changes in patellar tendon properties in female soccer players
Collagen supplementation augments changes in patellar tendon properties in female soccer players Open
We investigated the effect of collagen hydrolysate supplementation on changes in patellar tendon (PT) properties after 10 weeks’ training in female soccer players from a Football Association Women’s Super League Under 21 s squad. We pair-m…
View article: Serum concentration impacts myosin heavy chain expression but not cellular respiration in human LHCN‐M2 myoblasts undergoing differentiation
Serum concentration impacts myosin heavy chain expression but not cellular respiration in human LHCN‐M2 myoblasts undergoing differentiation Open
The human LHCN‐M2 myoblast cell line has the potential to be used to investigate skeletal muscle development and metabolism. Experiments were performed to determine how different concentrations of human serum affect myogenic differentiatio…
View article: The effect of a low carbohydrate high fat diet on lipid and lipoprotein metabolism: insight from a RCT
The effect of a low carbohydrate high fat diet on lipid and lipoprotein metabolism: insight from a RCT Open
Metabolic diseases are the leading global causes of death(1).Low carbohydrate, high fat (LCHF) diets improve markers of metabolic health and can mitigate disease risk(Reference Mansoor, Vinknes and Veierod2) however, the mechanisms are poo…
View article: PCM1 labeling reveals myonuclear and nuclear dynamics in skeletal muscle across species
PCM1 labeling reveals myonuclear and nuclear dynamics in skeletal muscle across species Open
Myonuclei transcriptionally regulate muscle fibers during homeostasis and adaptation to exercise. Their subcellular location and quantity are important when characterizing phenotypes of myopathies, the effect of treatments, and understandi…
View article: An investigation of movement dynamics and muscle activity during traditional and accentuated-eccentric squatting
An investigation of movement dynamics and muscle activity during traditional and accentuated-eccentric squatting Open
Introduction Accentuated-eccentric loading (AEL) takes advantage of the high force producing potential of eccentric muscle contractions, potentially maximising mechanical tension within the muscle. However, evidence is lacking on how AEL s…
View article: The Effect of Dietary Carbohydrate and Fat Manipulation on the Metabolome and Markers of Glucose and Insulin Metabolism: A Randomised Parallel Trial
The Effect of Dietary Carbohydrate and Fat Manipulation on the Metabolome and Markers of Glucose and Insulin Metabolism: A Randomised Parallel Trial Open
High carbohydrate, lower fat (HCLF) diets are recommended to reduce cardiometabolic disease (CMD) but low carbohydrate high fat (LCHF) diets can be just as effective. The effect of LCHF on novel insulin resistance biomarkers and the metabo…
View article: Developing an ecological approach to physical activity promotion in adults with Cystic fibrosis
Developing an ecological approach to physical activity promotion in adults with Cystic fibrosis Open
Background There are few examples of interventions designed to promote physical activity (PA) in adults with Cystic fibrosis (CF). Increasing levels of habitual PA may be more feasible and result in greater compliance than conventional exe…
View article: Degradation of ribosomal and chaperone proteins is attenuated during the differentiation of replicatively aged C2C12 myoblasts
Degradation of ribosomal and chaperone proteins is attenuated during the differentiation of replicatively aged C2C12 myoblasts Open
Background Cell assays are important for investigating the mechanisms of ageing, including losses in protein homeostasis and ‘proteostasis collapse’. We used novel isotopic labelling and proteomic methods to investigate protein turnover in…
View article: Replicative ageing perturbs the metabolic signature of murine C<sub>2</sub>C<sub>12</sub> skeletal myotubes
Replicative ageing perturbs the metabolic signature of murine C<sub>2</sub>C<sub>12</sub> skeletal myotubes Open
Introduction Chronological ageing is associated with mitochondrial dysfunction and increased reactive oxygen species (ROS) production in skeletal muscle. However, the effects of replicative ageing on skeletal muscle cellular metabolism are…
View article: Polygenic mechanisms underpinning the response to exercise‐induced muscle damage in humans: In vivo and in vitro evidence
Polygenic mechanisms underpinning the response to exercise‐induced muscle damage in humans: In vivo and in vitro evidence Open
We investigated whether 20 candidate single nucleotide polymorphisms (SNPs) were associated with in vivo exercise‐induced muscle damage (EIMD), and with an in vitro skeletal muscle stem cell wound healing assay. Sixty‐five young, untrained…
View article: (–)‐Epicatechin Alters Reactive Oxygen and Nitrogen Species Production Independent of Mitochondrial Respiration in Human Vascular Endothelial Cells
(–)‐Epicatechin Alters Reactive Oxygen and Nitrogen Species Production Independent of Mitochondrial Respiration in Human Vascular Endothelial Cells Open
Introduction . Vascular endothelial dysfunction is characterised by lowered nitric oxide (NO) bioavailability, which may be explained by increased production of reactive oxygen species (ROS), mitochondrial dysfunction, and altered cell sig…
View article: Multiscale-Engineered Muscle Constructs: PEG Hydrogel Micro-Patterning on an Electrospun PCL Mat Functionalized with Gold Nanoparticles
Multiscale-Engineered Muscle Constructs: PEG Hydrogel Micro-Patterning on an Electrospun PCL Mat Functionalized with Gold Nanoparticles Open
The development of new, viable, and functional engineered tissue is a complex and challenging task. Skeletal muscle constructs have specific requirements as cells are sensitive to the stiffness, geometry of the materials, and biological mi…
View article: (–)-Epicatechin alters reactive oxygen and nitrogen species production independent of mitochondrial respiration in human vascular endothelial cells
(–)-Epicatechin alters reactive oxygen and nitrogen species production independent of mitochondrial respiration in human vascular endothelial cells Open
Introduction Vascular endothelial dysfunction is characterised by lowered nitric oxide (NO) bioavailability, which may be explained by increased production of reactive oxygen species (ROS), mitochondrial dysfunction and altered cell signal…
View article: Degradation of ribosome and chaperone proteins is attenuated during the Differentiation of Replicatively Aged C2C12 Myoblasts
Degradation of ribosome and chaperone proteins is attenuated during the Differentiation of Replicatively Aged C2C12 Myoblasts Open
Age-related impairments in myoblast differentiation may contribute to reductions in muscle function in older adults, however, the underlying proteostasis processes are not well understood. Young (P6-10) and replicatively aged (P48-50) C 2 …
View article: Aging, Skeletal Muscle, and Epigenetics
Aging, Skeletal Muscle, and Epigenetics Open
Summary: We are living in an aging society. In 2019, 1 billion individuals were already aged over 60. The number of people in this demographic is predicted to reach 1.4 billion by 2030 and 2.1 billion by 2050 (WHO). In the USA, individuals…
View article: Stem cells and regenerative medicine in sport science
Stem cells and regenerative medicine in sport science Open
The estimated cost of acute injuries in college-level sport in the USA is ∼1.5 billion dollars per year, without taking into account the cost of follow up rehabilitation. In addition to this huge financial burden, without appropriate diagn…
View article: “Fuel for the Damage Induced”: Untargeted Metabolomics in Elite Rugby Union Match Play
“Fuel for the Damage Induced”: Untargeted Metabolomics in Elite Rugby Union Match Play Open
The metabolic perturbations caused by competitive rugby are not well characterized. Our aim is to utilize untargeted metabolomics to develop appropriate interventions, based on the metabolic fluctuations that occur in response to this coll…
View article: Are acute sitting-induced changes in inflammation and cerebrovascular function related to impaired mood and cognition?
Are acute sitting-induced changes in inflammation and cerebrovascular function related to impaired mood and cognition? Open
Purpose Sedentary behaviour is negatively associated with mood and cognition, yet how acute sitting contributes to these overall associations is unknown. Since sitting heightens inflammation and impairs cerebrovascular function, this study…
View article: Mechanical loading of bioengineered skeletal muscle in vitro recapitulates gene expression signatures of resistance exercise in vivo
Mechanical loading of bioengineered skeletal muscle in vitro recapitulates gene expression signatures of resistance exercise in vivo Open
Understanding the role of mechanical loading and exercise in skeletal muscle (SkM) is paramount for delineating the molecular mechanisms that govern changes in muscle mass. However, it is unknown whether loading of bioengineered SkM in vit…
View article: Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss
Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss Open
The COVID-19 pandemic is an extraordinary global emergency that has led to the implementation of unprecedented measures in order to stem the spread of the infection. Internationally, governments are enforcing measures such as travel bans, …