Claire Usal
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View article: CD4+ and CD8+ regulatory T cell characterization in the rat using a unique transgenic Foxp3-EGFP model
CD4+ and CD8+ regulatory T cell characterization in the rat using a unique transgenic Foxp3-EGFP model Open
View article: IL‐34 deficiency impairs FOXP3<sup>+</sup> Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis
IL‐34 deficiency impairs FOXP3<sup>+</sup> Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis Open
Background Immune homeostasis requires fully functional Tregs with a stable phenotype to control autoimmunity. Although IL‐34 is a cytokine first described as mainly involved in monocyte cell survival and differentiation, we recently descr…
View article: IL-34 deficiency impairs FOXP3<sup>+</sup> Treg function and increases susceptibility to autoimmunity
IL-34 deficiency impairs FOXP3<sup>+</sup> Treg function and increases susceptibility to autoimmunity Open
Immune homeostasis requires fully functional Tregs with a stable phenotype to control autoimmunity. Although IL-34 is a cytokine first described as mainly involved in monocyte cell survival and differentiation, we recently described its ex…
View article: CD4<sup>+</sup>and CD8<sup>+</sup>regulatory T cells characterization in the rat using a unique transgenic<i>Foxp3-EGFP</i>model
CD4<sup>+</sup>and CD8<sup>+</sup>regulatory T cells characterization in the rat using a unique transgenic<i>Foxp3-EGFP</i>model Open
Background CD4 + and CD8 + regulatory T cells (Treg) in diverse species include different subsets from different origins. In all species, CD8 + Treg have been poorly characterized. CD4 + and CD8 + Treg in rats have only partially been char…
View article: Cross-Reactive Donor-Specific CD8+ Tregs Efficiently Prevent Transplant Rejection
Cross-Reactive Donor-Specific CD8+ Tregs Efficiently Prevent Transplant Rejection Open
View article: Characterization of two rat models of cystic fibrosis—KO and F508del CFTR—Generated by Crispr‐Cas9
Characterization of two rat models of cystic fibrosis—KO and F508del CFTR—Generated by Crispr‐Cas9 Open
Background Genetically engineered animals are essential for gaining a proper understanding of the disease mechanisms of cystic fibrosis (CF). The rat is a relevant laboratory model for CF because of its zootechnical capacity, size, and air…
View article: In Vivo Analysis of Human Immune Responses in Immunodeficient Rats
In Vivo Analysis of Human Immune Responses in Immunodeficient Rats Open
Background. Humanized immune system immunodeficient mice have been extremely useful for the in vivo analyses of immune responses in a variety of models, including organ transplantation and graft versus host disease (GVHD) but they have lim…
View article: Immunological characterization of a rat model of Duchenne’s disease and increase in muscle strength after anti-CD45RC antibody treatment
Immunological characterization of a rat model of Duchenne’s disease and increase in muscle strength after anti-CD45RC antibody treatment Open
In this study, we phenotyped by flow cytometry and immunohistochemistry (data not shown) the immune cell subsets infiltrating Dmd mdx rat skeletal and cardiac muscles. Leukocyte infiltrates were absent or very low at 2 weeks of age, peaked…
View article: Generation of gene-edited rats by delivery of CRISPR/Cas9 protein and donor DNA into intact zygotes using electroporation
Generation of gene-edited rats by delivery of CRISPR/Cas9 protein and donor DNA into intact zygotes using electroporation Open
The generation of gene-edited animals using the CRISPRs/Cas9 system is based on microinjection into zygotes which is inefficient, time consuming and demands high technical skills. We report the optimization of an electroporation method for…
View article: Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA Rats
Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA Rats Open
View article: Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins
Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins Open
View article: IL-34 is a Treg-specific cytokine and mediates transplant tolerance
IL-34 is a Treg-specific cytokine and mediates transplant tolerance Open
Cytokines and metabolic pathway-controlling enzymes regulate immune responses and have potential as powerful tools to mediate immune tolerance. Blockade of the interaction between CD40 and CD40L induces long-term cardiac allograft survival…