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View article: Toward an all-in-one recombinant adeno-associated virus vector for functionally ablating the prion gene using CRISPR-Cas technology
Toward an all-in-one recombinant adeno-associated virus vector for functionally ablating the prion gene using CRISPR-Cas technology Open
Any strategy that can selectively and persistently lower the brain levels of the cellular prion protein (PrP C ) is expected to extend survival in prion diseases. Recent advances in the virus-mediated delivery of gene therapies prompted us…
View article: The importance of prion research
The importance of prion research Open
Over the past four decades, prion diseases have received considerable research attention owing to their potential to be transmitted within and across species as well as their consequences for human and animal health. The unprecedented natu…
View article: Advances in Recombinant Adeno-Associated Virus Vectors for Neurodegenerative Diseases
Advances in Recombinant Adeno-Associated Virus Vectors for Neurodegenerative Diseases Open
Recombinant adeno-associated virus (rAAV) vectors are gene therapy delivery tools that offer a promising platform for the treatment of neurodegenerative diseases. Keeping up with developments in this fast-moving area of research is a chall…
View article: Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation
Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation Open
The neuroendocrine peptide somatostatin (SST) has long been thought of as influencing the deposition of the amyloid β peptide (Aβ) in Alzheimer’s disease (AD). Missing have been in vivo data in a relevant Aβ amyloidosis model. Here we cros…
View article: Somatostatin slows Aβ plaque deposition in aged <i>APP<sup>NL-F/NL-F</sup></i> mice by blocking Aβ aggregation in a neprilysin-independent manner
Somatostatin slows Aβ plaque deposition in aged <i>APP<sup>NL-F/NL-F</sup></i> mice by blocking Aβ aggregation in a neprilysin-independent manner Open
The molecular underpinnings that govern the endoproteolytic release of the amyloid beta peptide (Aβ) from the amyloid precursor protein (APP) are now quite well understood. The same cannot be said for the events that precipitate the aggreg…
View article: The cellular prion protein interacts with and promotes the activity of Na,K-ATPases
The cellular prion protein interacts with and promotes the activity of Na,K-ATPases Open
The prion protein (PrP) is best known for its ability to cause fatal neurodegenerative diseases in humans and animals. Here, we revisited its molecular environment in the brain using a well-developed affinity-capture mass spectrometry work…