Clara Abraham
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View article: Autophagy and Bacterial infections
Autophagy and Bacterial infections Open
Autophagy is an evolutionarily conserved cellular process that is prominent during bacterial infections. In this review article, we discuss how direct pathogen clearance via xenophagy and regulation of inflammatory products represent dual …
View article: Roles of endothelial cells during infection
Roles of endothelial cells during infection Open
Endothelial cells (ECs) integrate immune and vascular functions to promote host defense against pathogens. While previously studied as forming passive flow conduits, ECs are now recognized as active contributors to maladaptive inflammation…
View article: Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting
Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting Open
The present report summarizes the United States Department of Veterans Affairs (VA) field-based meeting titled "Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans." Our Veteran patient population exper…
View article: ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis
ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis Open
Immune checkpoint inhibitors (ICIs) are increasingly being used to manage multiple tumor types. Unfortunately, immune-related adverse events affect up to 60% of recipients, often leading to treatment discontinuation in settings where few a…
View article: HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis
HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis Open
View article: IL-12 and IL-23 pathway inhibition in inflammatory bowel disease
IL-12 and IL-23 pathway inhibition in inflammatory bowel disease Open
View article: Pattern Recognition Receptor Signaling and Cytokine Networks in Microbial Defenses and Regulation of Intestinal Barriers: Implications for Inflammatory Bowel Disease
Pattern Recognition Receptor Signaling and Cytokine Networks in Microbial Defenses and Regulation of Intestinal Barriers: Implications for Inflammatory Bowel Disease Open
View article: Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response
Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response Open
Properly balancing microbial responses by the innate immune system through pattern recognition receptors (PRRs) is critical for intestinal immune homeostasis. Ring finger protein 186 (RNF186) genetic variants are associated with inflammato…
View article: The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair
The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair Open
View article: The E3 ubiquitin ligase RNF186 and <i>RNF186</i> risk variants regulate innate receptor-induced outcomes
The E3 ubiquitin ligase RNF186 and <i>RNF186</i> risk variants regulate innate receptor-induced outcomes Open
Significance This study identifies a previously undefined role for the inflammatory bowel disease–associated gene RNF186 in innate immunity. RNF186 is expressed in human macrophages and promotes outcomes downstream of receptors responding …
View article: Challenges in IBD Research: Update on Progress and Prioritization of the CCFAʼs Research Agenda
Challenges in IBD Research: Update on Progress and Prioritization of the CCFAʼs Research Agenda Open
View article: TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants
TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants Open
We identify that autocrine/paracrine TNFSF15 is required for optimal PRR-enhanced antimicrobial pathways in macrophages, define mechanisms regulating TNFSF15-dependent bacterial clearance, and determine how the TNFSF15 IBD risk genotype mo…
View article: Myeloid Cell–Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and <i>IRF5</i> Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions
Myeloid Cell–Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and <i>IRF5</i> Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions Open
Common IRF5 genetic risk variants associated with multiple immune-mediated diseases are a major determinant of interindividual variability in pattern-recognition receptor (PRR)–induced cytokines in myeloid cells. However, how myeloid cell–…
View article: Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation
Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation Open
View article: Disease Risk–Associated Genetic Variants in <i>STAT1</i> and <i>STAT4</i> Function in a Complementary Manner to Increase Pattern-Recognition Receptor–Induced Outcomes in Human Macrophages
Disease Risk–Associated Genetic Variants in <i>STAT1</i> and <i>STAT4</i> Function in a Complementary Manner to Increase Pattern-Recognition Receptor–Induced Outcomes in Human Macrophages Open
STAT proteins can regulate both pro- and anti-inflammatory cytokine signaling. Therefore, identifying consequences of modulating expression of a given STAT is ultimately critical for determining its potential as a therapeutic target and fo…
View article: T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation
T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation Open
View article: IL23 Promotes Antimicrobial Pathways in Human Macrophages, Which Are Reduced With the IBD-Protective IL23R R381Q Variant
IL23 Promotes Antimicrobial Pathways in Human Macrophages, Which Are Reduced With the IBD-Protective IL23R R381Q Variant Open
View article: LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes
LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes Open
View article: STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor–Induced Inflammatory Cytokines, and <i>STAT3</i>/<i>STAT5</i> Disease Variants Modulate These Outcomes
STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor–Induced Inflammatory Cytokines, and <i>STAT3</i>/<i>STAT5</i> Disease Variants Modulate These Outcomes Open
Genetic variants in the STAT3/STAT5A/STAT5B region are associated with immune-mediated diseases, including inflammatory bowel disease (IBD). However, how STAT3 and STAT5 regulate the critical balance between pro- and anti-inflammatory cyto…
View article: Correction to: Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens
Correction to: Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens Open
View article: Challenges in IBD Research: Precision Medicine
Challenges in IBD Research: Precision Medicine Open
Precision medicine is part of five focus areas of the Challenges in IBD research document, which also includes preclinical human IBD mechanisms, environmental triggers, novel technologies, and pragmatic clinical research. The Challenges in…
View article: IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes
IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes Open
Objective The interleukin (IL)23 pathway contributes to IBD pathogenesis and is being actively studied as a therapeutic target in patients with IBD. Unexpected outcomes in these therapeutic trials have highlighted the importance of underst…
View article: Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens
Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens Open
View article: Twist1 and Twist2 Induce Human Macrophage Memory upon Chronic Innate Receptor Treatment by HDAC-Mediated Deacetylation of Cytokine Promoters
Twist1 and Twist2 Induce Human Macrophage Memory upon Chronic Innate Receptor Treatment by HDAC-Mediated Deacetylation of Cytokine Promoters Open
Intestinal tissues are continuously exposed to microbial products that stimulate pattern-recognition receptors (PRRs). Ongoing PRR stimulation can confer epigenetic changes in macrophages, which can then regulate subsequent immune outcomes…
View article: Prioritizing Crohn’s disease genes by integrating association signals with gene expression implicates monocyte subsets
Prioritizing Crohn’s disease genes by integrating association signals with gene expression implicates monocyte subsets Open
View article: IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and <i>IRF5</i> Immune-Mediated Disease Risk Variants Modulate This Outcome
IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and <i>IRF5</i> Immune-Mediated Disease Risk Variants Modulate This Outcome Open
Common IFN regulatory factor 5 (IRF5) variants associated with multiple immune-mediated diseases are a major determinant of interindividual variability in pattern recognition receptor (PRR)–induced cytokines in macrophages. PRR-initiated p…
View article: INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling
INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling Open
Homeostasis at mucosal surfaces requires cross-talk between the environment and barrier epithelial cells. Disruption of barrier function typifies mucosal disease. Here we elucidate a bifunctional role in coordinating this cross-talk for th…
View article: Author response: INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling
Author response: INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling Open
View article: IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes
IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes Open
View article: Erratum: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP
Erratum: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP Open