Clara C. Cousins
YOU?
Author Swipe
View article: Integration of transcriptomics, proteomics and loss-of-function screening reveals WEE1 as a target for combination with dasatinib against proneural glioblastoma
Integration of transcriptomics, proteomics and loss-of-function screening reveals WEE1 as a target for combination with dasatinib against proneural glioblastoma Open
Glioblastoma is characterized by a pronounced resistance to therapy with dismal prognosis. Transcriptomics classify glioblastoma into proneural (PN), mesenchymal (MES) and classical (CL) subtypes that show differential resistance to target…
View article: Genetic Correlations Among Corneal Biophysical Parameters and Anthropometric Traits
Genetic Correlations Among Corneal Biophysical Parameters and Anthropometric Traits Open
Local genetic covariance analysis enables the identification of associated genes and therapeutic targets for corneal ectatic disease.
View article: Deep Learning for Localized Detection of Optic Disc Hemorrhages
Deep Learning for Localized Detection of Optic Disc Hemorrhages Open
An autonomous object detection model is superior to an image classification model for detecting disc hemorrhages, and performed comparably to 2 clinicians.
View article: Genetic Associations Between Smoking- and Glaucoma-Related Traits
Genetic Associations Between Smoking- and Glaucoma-Related Traits Open
Understanding the genetic drivers of the inverse relationship between smoking and glaucoma could yield new insights into glaucoma pathophysiology.
View article: Paired Optic Nerve Microvasculature and Nailfold Capillary Measurements in Primary Open-Angle Glaucoma
Paired Optic Nerve Microvasculature and Nailfold Capillary Measurements in Primary Open-Angle Glaucoma Open
The concomitant abnormalities in nailfold capillaries and relevant ocular vascular beds in POAG suggest that the microvasculature may be a target for POAG treatment.
View article: Table of Contents
Table of Contents Open
View article: Regional Infoveillance of COVID-19 Case Rates: Analysis of Search-Engine Query Patterns
Regional Infoveillance of COVID-19 Case Rates: Analysis of Search-Engine Query Patterns Open
Background Timely allocation of medical resources for coronavirus disease (COVID-19) requires early detection of regional outbreaks. Internet browsing data may predict case outbreaks in local populations that are yet to be confirmed. Objec…
View article: Densitometric Profiles of Optic Disc Hemorrhages in the Ocular Hypertension Treatment Study
Densitometric Profiles of Optic Disc Hemorrhages in the Ocular Hypertension Treatment Study Open
View article: Regional Infoveillance of COVID-19 Case Rates: Analysis of Search-Engine Query Patterns (Preprint)
Regional Infoveillance of COVID-19 Case Rates: Analysis of Search-Engine Query Patterns (Preprint) Open
BACKGROUND Timely allocation of medical resources for coronavirus disease (COVID-19) requires early detection of regional outbreaks. Internet browsing data may predict case outbreaks in local populations that are yet to be confirmed. OB…
View article: A Framework for Patient Stratification in Clinical Trials for Alzheimer’s Disease Henry C Cousins1 and Clara C Cousins2*
A Framework for Patient Stratification in Clinical Trials for Alzheimer’s Disease Henry C Cousins1 and Clara C Cousins2* Open
Drug discovery efforts in Alzheimer’s disease depend increasingly
View article: Densitometry and geometry of optic disc hemorrhages in the Ocular Hypertension Treatment Study
Densitometry and geometry of optic disc hemorrhages in the Ocular Hypertension Treatment Study Open
View article: Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes
Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes Open
View article: Resting nailfold capillary blood flow in primary open-angle glaucoma
Resting nailfold capillary blood flow in primary open-angle glaucoma Open
Background/Aims An altered haemodynamic profile for various ocular posterior segment capillary beds has been documented in primary open-angle glaucoma (POAG). POAG may also involve abnormal non-ocular blood flow, and the nailfold capillari…
View article: A Novel Quantitative Approach for Analyzing Glaucomatous Disc Hemorrhages: Identifying the Source of the Blood
A Novel Quantitative Approach for Analyzing Glaucomatous Disc Hemorrhages: Identifying the Source of the Blood Open
View article: Nailfold capillary morphology in exfoliation syndrome
Nailfold capillary morphology in exfoliation syndrome Open
PurposeThe purpose of the study was to investigate nailfold microvascular morphology in exfoliation syndrome with or without glaucoma (XFS/XFG) compared with primary open-angle glaucoma (POAG) and control subjects using nailfold capillary …
View article: Nailfold Capillary Abnormalities in Primary Open-Angle Glaucoma: A Multisite Study
Nailfold Capillary Abnormalities in Primary Open-Angle Glaucoma: A Multisite Study Open
These data provided support for nonocular capillary bed abnormalities in POAG. Comparable vascular abnormalities in the optic nerve may render it susceptible to glaucomatous damage.