Clara Casey
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View article: Dopamine receptor 1-expressing cells in the ventral hippocampus encode cocaine-context associations
Dopamine receptor 1-expressing cells in the ventral hippocampus encode cocaine-context associations Open
Dopamine (DA) signaling facilitates emotional valence, reward prediction error, and motivation; thus, dysfunctional dopamine signaling has been tied to several neuropsychiatric disorders, including substance use disorder (SUD). While most …
View article: Population-scale cross-disorder atlas of the human prefrontal cortex at single-cell resolution
Population-scale cross-disorder atlas of the human prefrontal cortex at single-cell resolution Open
Neurodegenerative diseases and serious mental illnesses often exhibit overlapping characteristics, highlighting the potential for shared underlying mechanisms. To facilitate a deeper understanding of these diseases and pave the way for mor…
View article: A multi-region single nucleus transcriptomic atlas of Parkinson’s disease
A multi-region single nucleus transcriptomic atlas of Parkinson’s disease Open
Parkinson’s Disease (PD) is a debilitating neurodegenerative disorder, characterized by motor and cognitive impairments, that affects >1% of the population over the age of 60. The pathogenesis of PD is complex and remains largely unknown. …
View article: A lifespan transcriptomic atlas of the human prefrontal cortex at single-cell resolution
A lifespan transcriptomic atlas of the human prefrontal cortex at single-cell resolution Open
The dorsolateral prefrontal cortex (DLPFC) underpins higher cognitive functions and is highly susceptible to age-related decline. However, a comprehensive, lifespan-resolved map of its cellular and molecular programs has been lacking. Here…
View article: Single-nucleus transcriptome-wide association study of human brain disorders
Single-nucleus transcriptome-wide association study of human brain disorders Open
Neuropsychiatric and neurodegenerative disorders exhibit cell-type-specific characteristics 1–8 , yet most transcriptome-wide association studies have been constrained by the use of homogenate brain tissue 9–11 , limiting their resolution …
View article: Single-cell atlas of transcriptomic vulnerability across multiple neurodegenerative and neuropsychiatric diseases
Single-cell atlas of transcriptomic vulnerability across multiple neurodegenerative and neuropsychiatric diseases Open
Neurodegenerative and neuropsychiatric diseases impose a significant societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited. To gain deeper insig…
View article: Unravelling the genetic basis of Schizophrenia
Unravelling the genetic basis of Schizophrenia Open
Neuronal development is a highly regulated mechanism that is central to organismal function in animals. In humans, disruptions to this process can lead to a range of neurodevelopmental phenotypes, including Schizophrenia (SCZ). SCZ has a s…
View article: Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer’s Disease
Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer’s Disease Open
The complex roles of myeloid cells, including microglia and perivascular macrophages, are central to the neurobiology of Alzheimer’s disease (AD), yet they remain incompletely understood. Here, we profiled 832,505 human myeloid cells from …
View article: Efficient differential expression analysis of large-scale single cell transcriptomics data using dreamlet
Efficient differential expression analysis of large-scale single cell transcriptomics data using dreamlet Open
Advances in single-cell and -nucleus transcriptomics have enabled generation of increasingly large-scale datasets from hundreds of subjects and millions of cells. These studies promise to give unprecedented insight into the cell type speci…
View article: Efficient differential expression analysis of large-scale single cell transcriptomics data using dreamlet
Efficient differential expression analysis of large-scale single cell transcriptomics data using dreamlet Open
Advances in single-cell and -nucleus transcriptomics have enabled generation of increasingly large-scale datasets from hundreds of subjects and millions of cells. These studies promise to give unprecedented insight into the cell type speci…