Clara D. Ledsky
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View article: The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease
The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease Open
Non-alcoholic fatty liver disease (NAFLD) affects over 30% of adults in the United States. Bone morphogenetic protein (BMP) signaling is known to contribute to hepatic fibrosis, but the role of BMP signaling in the development of NAFLD is …
View article: Blood Pressure-Associated Genetic Variants in the Natriuretic Peptide Receptor 1 Gene Modulate Guanylate Cyclase Activity
Blood Pressure-Associated Genetic Variants in the Natriuretic Peptide Receptor 1 Gene Modulate Guanylate Cyclase Activity Open
Background: Human genetic variation in the NPR1 (natriuretic peptide receptor 1 gene, encoding NPR-A, atrial natriuretic peptide receptor 1) was recently shown to affect blood pressure (BP). NPR-A catalyzes the intracellular conversion of …
View article: Hepcidin Deficiency Protects Against Atherosclerosis
Hepcidin Deficiency Protects Against Atherosclerosis Open
Objective— Inflammatory stimuli enhance the progression of atherosclerotic disease. Inflammation also increases the expression of hepcidin, a hormonal regulator of iron homeostasis, which decreases intestinal iron absorption, reduces serum…
View article: MicroRNA-425 and microRNA-155 cooperatively regulate atrial natriuretic peptide expression and cGMP production
MicroRNA-425 and microRNA-155 cooperatively regulate atrial natriuretic peptide expression and cGMP production Open
These data demonstrate that miR-425 and miR-155 regulate NPPA expression in a cooperative manner. Targeting both miRNAs with anti-miRs (possibly at submaximal concentrations) might prove to be a more effective strategy to modulate ANP leve…