Clara Hellberg
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View article: Unscheduled pain specialist intervention in one-third of IBD surgical cases: a retrospective cohort study
Unscheduled pain specialist intervention in one-third of IBD surgical cases: a retrospective cohort study Open
Background Patients with inflammatory bowel disease (IBD) differ significantly from the general abdominal surgery population. They are younger and more likely to present with psychiatric comorbidities such as anxiety and depression, as wel…
View article: Antihistamine use and osteoarthritis or joint pain
Antihistamine use and osteoarthritis or joint pain Open
In a large population-based observational cohort, use of antihistamines was neither associated with less joint pain/osteoarthritis nor lower risk of future osteoarthritis.
View article: Association of Body Mass Index and Parkinson Disease
Association of Body Mass Index and Parkinson Disease Open
Using an independent data set (Courage-PD), we replicate an inverse association of genetically predicted BMI with PD, not explained by survival or incidence-prevalence biases. Moreover, reverse MR analyses support an inverse association be…
View article: Outcomes >30 Years After Initial Nonoperative Treatment of Anterior Cruciate Ligament Injuries
Outcomes >30 Years After Initial Nonoperative Treatment of Anterior Cruciate Ligament Injuries Open
Background: It is unclear how anterior cruciate ligament (ACL) reconstruction (ACLR) affects the development of osteoarthritis (OA). This uncertainty is partly caused by the lack of long-term studies on ACL injuries treated primarily witho…
View article: Use of non-surgical treatments on the journey to knee replacement in patients with knee osteoarthritis: a 10-year population-based case–control study
Use of non-surgical treatments on the journey to knee replacement in patients with knee osteoarthritis: a 10-year population-based case–control study Open
Aim To investigate temporal trends in primary care visits, physiotherapy visits, dispensed non-steroidal anti-inflammatory drugs (NSAIDs) and opioids in knee osteoarthritis (OA) patients who have and have not undergone knee replacement. Me…
View article: Identifying Non-Steroidal Anti-Inflammatory Drug (NSAID) Users Among People with Osteoarthritis Through Administrative and Clinician-Reported Data – A Validation Study of 116,162 Patients
Identifying Non-Steroidal Anti-Inflammatory Drug (NSAID) Users Among People with Osteoarthritis Through Administrative and Clinician-Reported Data – A Validation Study of 116,162 Patients Open
Overall, 24.7% of participants in a first-line intervention for OA used OTC NSAIDs only while 18.2% used prescribed NSAIDs. Dispensed prescriptions of NSAIDs have high specificity but low sensitivity and can correctly identify about 70% of…
View article: Road to Total Knee Replacement: Utilization of Knee Surgeries Up to Ten Years Before Total Knee Replacement in England and Sweden
Road to Total Knee Replacement: Utilization of Knee Surgeries Up to Ten Years Before Total Knee Replacement in England and Sweden Open
Objective To compare the prevalence and timing of knee surgery (including meniscal, ligamentous, synovial, and osteotomy) in the 10 years prior to primary total knee replacement (TKR) between England and Sweden. Methods This was a populati…
View article: Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease
Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease Open
Our study further refines the genetic architecture of Chr 4 underlying the AAO of the PD phenotype through the identification of BST1 as a novel AAO PD locus. These findings open a new direction for the development of treatments to delay t…
View article: Opioid use prior to total knee replacement: comparative analysis of trends in England and Sweden
Opioid use prior to total knee replacement: comparative analysis of trends in England and Sweden Open
Temporal prevalence patterns of opioid prescribing between cases and controls are similar in England and Sweden. Opioids are still commonly used in TKR cases in both countries highlighting the lack of valid alternatives for OA pain managem…
View article: Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson’s Disease
Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson’s Disease Open
Background: Previous studies showed that lifestyle behaviors (cigarette smoking, alcohol, coffee) are inversely associated with Parkinson’s disease (PD). The prodromal phase of PD raises the possibility that these associations may be expla…