Clara Locher
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View article: Rapid-sequence clinical research before and during a pandemic: Lessons learned and the way forward
Rapid-sequence clinical research before and during a pandemic: Lessons learned and the way forward Open
In the aftermath of the COVID-19 pandemic, the structuring of a nationwide research network for preparation and response to emerging infectious diseases (EID) with epidemic or pandemic potential has become increasingly essential. A nationw…
View article: Endo‐Epicardial vs. Endocardial‐Only Catheter Ablation of Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy: The EPIC‐VT Trial Design
Endo‐Epicardial vs. Endocardial‐Only Catheter Ablation of Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy: The EPIC‐VT Trial Design Open
Introduction Radiofrequency ablation is a cornerstone therapy for patients with ischemic cardiomyopathy (ICM) presenting with ventricular tachycardia (VT). In this context, ablation is typically performed endocardially as a first‐line appr…
View article: Trends of Publication of Negative Trials Over Time
Trends of Publication of Negative Trials Over Time Open
Studies with negative results are less likely to be published than others, potentially leading to publication bias. Introduced in 2000, trial registration could have participated in decreasing the proportion of unpublished studies. We asse…
View article: Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project
Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project Open
Background The aim of the INSPECT-SR project is to develop a tool to identify problematic RCTs in systematic reviews. In Stage 1 of the project, a list of potential trustworthiness checks was created. The checks on this list must be evalua…
View article: Meta‐analyses of phase I dose‐finding studies: Application for the development of protein kinase inhibitors in oncology
Meta‐analyses of phase I dose‐finding studies: Application for the development of protein kinase inhibitors in oncology Open
This study aimed to assess the feasibility of applying two recent phase I meta‐analyses methods to protein kinase inhibitors (PKIs) developed in oncology and to identify situations where these methods could be both feasible and useful. Thi…
View article: Reporting of interventional clinical trial results in an academic center: a survey of completed studies
Reporting of interventional clinical trial results in an academic center: a survey of completed studies Open
View article: Reporting of interventional clinical trial results in a French academic center: a survey of completed studies
Reporting of interventional clinical trial results in a French academic center: a survey of completed studies Open
Background : The dissemination of clinical trial results is an important scientific and ethical endeavour. This survey of completed interventional studies in a French academic center describes their reporting status. Methods : We explored …
View article: Making data sharing the norm in medical research
Making data sharing the norm in medical research Open
International audience
View article: Data from Integration of Host-Related Signatures with Cancer Cell–Derived Predictors for the Optimal Management of Anticancer Chemotherapy
Data from Integration of Host-Related Signatures with Cancer Cell–Derived Predictors for the Optimal Management of Anticancer Chemotherapy Open
Current cancer management aims to integrate molecular signatures into the design of personalized therapies. Recent advances in “omics” done on tumor specimens have led to the identification of factors that either recognize cancers of disma…
View article: Data from Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors
Data from Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors Open
Cancer immunosurveillance relies on effector/memory tumor-infiltrating CD8+ T cells with a T-helper cell 1 (TH1) profile. Evidence for a natural killer (NK) cell-based control of human malignancies is still largely mi…
View article: Supplementary Tables 1-3 from Integration of Host-Related Signatures with Cancer Cell–Derived Predictors for the Optimal Management of Anticancer Chemotherapy
Supplementary Tables 1-3 from Integration of Host-Related Signatures with Cancer Cell–Derived Predictors for the Optimal Management of Anticancer Chemotherapy Open
Supplementary Tables 1-3 from Integration of Host-Related Signatures with Cancer Cell–Derived Predictors for the Optimal Management of Anticancer Chemotherapy
View article: Data from Integration of Host-Related Signatures with Cancer Cell–Derived Predictors for the Optimal Management of Anticancer Chemotherapy
Data from Integration of Host-Related Signatures with Cancer Cell–Derived Predictors for the Optimal Management of Anticancer Chemotherapy Open
Current cancer management aims to integrate molecular signatures into the design of personalized therapies. Recent advances in “omics” done on tumor specimens have led to the identification of factors that either recognize cancers of disma…
View article: Supplementary Tables 1 - 3, Figures 1 - 2 from Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors
Supplementary Tables 1 - 3, Figures 1 - 2 from Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors Open
PDF file - 197K, Supplemental Table 1. Characteristics of GIST patients for the immunohistochemistry study. Supplemental Table 2. Characteristics of GIST and STS patients studied in flow cytometry. Supplemental Table 3: Antibodies for flow…
View article: Data from Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors
Data from Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors Open
Cancer immunosurveillance relies on effector/memory tumor-infiltrating CD8+ T cells with a T-helper cell 1 (TH1) profile. Evidence for a natural killer (NK) cell-based control of human malignancies is still largely mi…
View article: Supplementary Tables 1 - 3, Figures 1 - 2 from Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors
Supplementary Tables 1 - 3, Figures 1 - 2 from Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors Open
PDF file - 197K, Supplemental Table 1. Characteristics of GIST patients for the immunohistochemistry study. Supplemental Table 2. Characteristics of GIST and STS patients studied in flow cytometry. Supplemental Table 3: Antibodies for flow…
View article: Supplementary Tables 1-3 from Integration of Host-Related Signatures with Cancer Cell–Derived Predictors for the Optimal Management of Anticancer Chemotherapy
Supplementary Tables 1-3 from Integration of Host-Related Signatures with Cancer Cell–Derived Predictors for the Optimal Management of Anticancer Chemotherapy Open
Supplementary Tables 1-3 from Integration of Host-Related Signatures with Cancer Cell–Derived Predictors for the Optimal Management of Anticancer Chemotherapy
View article: Rapid access to innovative medicinal products while ensuring relevant health technology assessment. Position of the French National Authority for Health
Rapid access to innovative medicinal products while ensuring relevant health technology assessment. Position of the French National Authority for Health Open
International audience
View article: Implementing clinical trial data sharing requires training a new generation of biomedical researchers
Implementing clinical trial data sharing requires training a new generation of biomedical researchers Open
View article: Tivozanib in renal cell carcinoma: a systematic review of the evidence and its dissemination in the scientific literature
Tivozanib in renal cell carcinoma: a systematic review of the evidence and its dissemination in the scientific literature Open
View article: Correction: A survey of biomedical journals to detect editorial bias and nepotistic behavior
Correction: A survey of biomedical journals to detect editorial bias and nepotistic behavior Open
[This corrects the article DOI: 10.1371/journal.pbio.3001133.].
View article: Les travers du système de publication scientifique
Les travers du système de publication scientifique Open
View article: A survey of biomedical journals to detect editorial bias and nepotistic behavior
A survey of biomedical journals to detect editorial bias and nepotistic behavior Open
Alongside the growing concerns regarding predatory journal growth, other questionable editorial practices have gained visibility recently. Among them, we explored the usefulness of the Percentage of Papers by the Most Prolific author (PPMP…
View article: Clinical trials during pandemics and beyond: time for a more efficient pharmacological strategy
Clinical trials during pandemics and beyond: time for a more efficient pharmacological strategy Open
During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, clinical trials on antiviral or symptomatic drugs have been conducted very rapidly even for drugs with a poor pharmacological rationale for efficacy on SARS-…
View article: Publication by association: how the COVID-19 pandemic has shown relationships between authors and editorial board members in the field of infectious diseases
Publication by association: how the COVID-19 pandemic has shown relationships between authors and editorial board members in the field of infectious diseases Open
During the COVID-19 pandemic, the rush to scientific and political judgements on the merits of hydroxychloroquine was fuelled by dubious papers which may have been published because the authors were not independent from the practices of th…
View article: ‘Nepotistic journals’: a survey of biomedical journals
‘Nepotistic journals’: a survey of biomedical journals Open
Context Convergent analyses in different disciplines support the use of the Percentage of Papers by the Most Prolific author (PPMP) as a red flag to identify journals that can be suspected of questionable editorial practices. We examined w…
View article: Hypothermic Oxygenated Perfusion Improves Extended Criteria Donor Liver Graft Function and Reduces Duration of Hospitalization Without Extra Cost: The PERPHO Study
Hypothermic Oxygenated Perfusion Improves Extended Criteria Donor Liver Graft Function and Reduces Duration of Hospitalization Without Extra Cost: The PERPHO Study Open
Few studies have evaluated the efficacy or the cost of hypothermic oxygenated perfusion (HOPE) in the conservation of extended criteria donor (ECD) grafts from donation after brain death (DBD) donors during liver transplantation (LT). We p…
View article: The role of eosinophil morphology in distinguishing between reactive eosinophilia and eosinophilia as a feature of a myeloid neoplasm
The role of eosinophil morphology in distinguishing between reactive eosinophilia and eosinophilia as a feature of a myeloid neoplasm Open
Summary Morphological features of eosinophils in patients with reactive eosinophilia (28 patients) and clonal eosinophilia (26 patients) have been compared with each other and with the eosinophil characteristics of healthy volunteers (thre…
View article: Letter to the editor: Covid-19 and Vit-D: Disease mortality negatively correlates with sunlight exposure
Letter to the editor: Covid-19 and Vit-D: Disease mortality negatively correlates with sunlight exposure Open
View article: Publication by association: the Covid-19 pandemic reveals relationships between authors and editors
Publication by association: the Covid-19 pandemic reveals relationships between authors and editors Open
During the COVID-19 pandemic, the rush to scientific and political judgments on the merits of hydroxychloroquine was fuelled by dubious papers which may have been published because the authors were not independent from the practices of the…
View article: Outcome of patients treated with molecular adsorbent recirculating system albumin dialysis: A national multicenter study
Outcome of patients treated with molecular adsorbent recirculating system albumin dialysis: A national multicenter study Open
Background and Aim The molecular adsorbent recirculating system (MARS) is the most widely used device to treat liver failure. Nevertheless, data from widespread real‐life use are lacking. Methods This was a retrospective multicenter study …