Clara Moon
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View article: Allosteric modulation of the solute carrier transporter SLC39A8 potentiates manganese and cadmium uptake
Allosteric modulation of the solute carrier transporter SLC39A8 potentiates manganese and cadmium uptake Open
Solute carrier (SLC) transporters govern the selective transport of diverse molecules across cell membranes, controlling fundamental metabolic and cellular processes. Despite genetic evidence implicating SLC transporters in a variety of hu…
View article: Metabolomics activity screening of T cell–induced colitis reveals anti-inflammatory metabolites
Metabolomics activity screening of T cell–induced colitis reveals anti-inflammatory metabolites Open
Metabolites that are dysregulated in a mouse model of inflammatory bowel disease are identified and characterized.
View article: Metaproteomics of Colonic Microbiota Unveils Discrete Protein Functions among Colitic Mice and Control Groups
Metaproteomics of Colonic Microbiota Unveils Discrete Protein Functions among Colitic Mice and Control Groups Open
Metaproteomics can greatly assist established high‐throughput sequencing methodologies to provide systems biological insights into the alterations of microbial protein functionalities correlated with disease‐associated dysbiosis of the int…
View article: Metaproteomics of colonic microbiota unveils discrete protein functions among colitic mice and control groups
Metaproteomics of colonic microbiota unveils discrete protein functions among colitic mice and control groups Open
Metaproteomics can greatly assist established high-throughput sequencing methodologies to provide systems biological insights into the alterations of microbial protein functionalities correlated with disease-associated dysbiosis of the int…
View article: Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria
Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria Open
Cysteine proteases are among the most abundant hydrolytic enzymes produced by bacteria, and this diverse family of proteins have significant biological roles in bacterial viability and environmental interactions. Members of the clostripain…
View article: P068 Evaluation of the therapeutic potential of metformin-pretreated tonsil-derived mesenchymal stem cells in a chronic colitis model
P068 Evaluation of the therapeutic potential of metformin-pretreated tonsil-derived mesenchymal stem cells in a chronic colitis model Open
Background: Tonsil-derived mesenchymal stem cells (TMSCs), prepared after tonsillectomy in human, have many advantages including a short doubling time, high differentiation capacity, and mixed chimerism property. Metformin has an anti-infl…
View article: Quantitative Metaproteomics and Activity-Based Probe Enrichment Reveals Significant Alterations in Protein Expression from a Mouse Model of Inflammatory Bowel Disease
Quantitative Metaproteomics and Activity-Based Probe Enrichment Reveals Significant Alterations in Protein Expression from a Mouse Model of Inflammatory Bowel Disease Open
Tandem mass spectrometry based shotgun proteomics of distal gut microbiomes is exceedingly difficult due to the inherent complexity and taxonomic diversity of the samples. We introduce two new methodologies to improve metaproteomic studies…