Clara Pfäffle
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View article: Measuring choriocapillaris blood flow with laser Doppler optical coherence tomography
Measuring choriocapillaris blood flow with laser Doppler optical coherence tomography Open
We report on using a laser Doppler processing of Fourier-domain optical coherence tomography (OCT) data for the assessment of pulsatile blood flow in the choriocapillaris. Signal fluctuations in B-scans recorded at 2 kHz were analyzed by F…
View article: Unraveling the functional signals of rods and cones in the human retina: separation and analysis
Unraveling the functional signals of rods and cones in the human retina: separation and analysis Open
In recent years, optoretinography has become an important functional imaging method for the retina, as light-evoked changes in the photoreceptors have been demonstrated for a large number of different OCT systems. Full-field swept-source o…
View article: Diffuse-illumination holographic optical coherence tomography
Diffuse-illumination holographic optical coherence tomography Open
Holographic optical coherence tomography (OCT) is a powerful imaging technique, but its ability to reveal low-reflectivity features is limited. In this study, we performed holographic OCT by incoherently averaging volumes with changing dif…
View article: Diffuse-illumination holographic optical coherence tomography
Diffuse-illumination holographic optical coherence tomography Open
Holographic optical coherence tomography (OCT) is a powerful imaging technique, but its ability to reveal low-reflectivity features is limited. In this study, we performed holographic OCT by incoherently averaging volumes with changing dif…
View article: Phase-Sensitive Measurements of Depth-Dependent Signal Transduction in the Inner Plexiform Layer
Phase-Sensitive Measurements of Depth-Dependent Signal Transduction in the Inner Plexiform Layer Open
Non-invasive spatially resolved functional imaging in the human retina has recently attracted considerable attention. Particularly functional imaging of bipolar and ganglion cells could aid in studying neuronal activity in humans, includin…
View article: Simultaneous functional imaging the physiological response of neuronal and photoreceptor layers to varying stimuli in living human retina
Simultaneous functional imaging the physiological response of neuronal and photoreceptor layers to varying stimuli in living human retina Open
View article: Determination and correction of aberrations in full field OCT using phase gradient autofocus by maximizing the likelihood function
Determination and correction of aberrations in full field OCT using phase gradient autofocus by maximizing the likelihood function Open
A method for numerical estimation and correction of aberrations of the eye in fundus imaging with optical coherence tomography (OCT) is presented. Aberrations are determined statistically by using the estimate based on likelihood function …
View article: Phase-sensitive interferometry of decorrelated speckle patterns
Phase-sensitive interferometry of decorrelated speckle patterns Open
Phase-sensitive coherent imaging exploits changes in the phases of backscattered light to observe tiny alterations of scattering structures or variations of the refractive index. But moving scatterers or a fluctuating refractive index deco…
View article: Functional retinal imaging with full-field swept-source OCT using enhanced processing algorithms
Functional retinal imaging with full-field swept-source OCT using enhanced processing algorithms Open
View article: Functional imaging of retinal neurons using OCT
Functional imaging of retinal neurons using OCT Open
View article: Phase-sensitive interferometry of decorrelated speckle patterns
Phase-sensitive interferometry of decorrelated speckle patterns Open
Phase-sensitive coherent imaging exploits changes in the phases of backscattered light to observe tiny alterations of scattering structures or variations of the refractive index. But moving scatterers or a fluctuating refractive index deco…
View article: In Vivo FF-SS-OCT Optical Imaging of Physiological Responses to Photostimulation of Human Photoreceptor Cells
In Vivo FF-SS-OCT Optical Imaging of Physiological Responses to Photostimulation of Human Photoreceptor Cells Open
Optical coherence tomography (OCT) has changed diagnostics in ophthalmology by visualizing the morphology of retinal cell layers, which play an important role in human vision. Direct visualization of the activity of these different layers …
View article: Functional imaging of ganglion and receptor cells in living human retina by osmotic contrast
Functional imaging of ganglion and receptor cells in living human retina by osmotic contrast Open
Imaging neuronal activity non-invasively in vivo is of tremendous interest, but current imaging techniques lack either functional contrast or necessary microscopic resolution. The retina is the only part of the central nervous system (CNS)…
View article: Functional imaging of ganglion and receptor cells in living human retina\n by osmotic contrast
Functional imaging of ganglion and receptor cells in living human retina\n by osmotic contrast Open
Imaging neuronal activity non-invasively in vivo is of tremendous interest,\nbut current imaging techniques lack either functional contrast or necessary\nmicroscopic resolution. The retina is the only part of the central nervous\nsystem (C…
View article: Imaging motion in the retina in 3D using FF-SS-OCT
Imaging motion in the retina in 3D using FF-SS-OCT Open
View article: Physiologic origin of intrinsic optical signals in human retina
Physiologic origin of intrinsic optical signals in human retina Open
View article: Interferometric detection of 3D motion using computational subapertures in optical coherence tomography
Interferometric detection of 3D motion using computational subapertures in optical coherence tomography Open
Doppler optical coherence tomography (OCT) quantifies axial motion with high precision, whereas lateral motion cannot be detected by a mere evaluation of phase changes. This problem was solved by the introduction of three-beam Doppler OCT,…
View article: Reduction of frame rate in full-field swept-source optical coherence tomography by numerical motion correction [Invited]
Reduction of frame rate in full-field swept-source optical coherence tomography by numerical motion correction [Invited] Open
Full-field swept-source optical coherence tomography (FF-SS-OCT) was recently shown to allow new and exciting applications for imaging the human eye that were previously not possible using current scanning OCT systems. However, especially …
View article: Aberration-free volumetric high-speed imaging of in vivo retina
Aberration-free volumetric high-speed imaging of in vivo retina Open
View article: In vivo optical imaging of physiological responses to photostimulation in human photoreceptors
In vivo optical imaging of physiological responses to photostimulation in human photoreceptors Open
Significance Using a full-field optical coherence tomography system, we measured changes in the time that light requires to pass through photoreceptor outer segments, when the retina is stimulated by a light pulse. This effect can be used …