Clara Williams
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View article: Co-design of an E-health Application to Improve the Perioperative Patient Journey and Facilitate Integrated Care
Co-design of an E-health Application to Improve the Perioperative Patient Journey and Facilitate Integrated Care Open
This research developed and evaluated usability of a co-designed e-health intervention to improve preparation for and recovery from surgery. The e-health intervention supports personalised care provision and self-management of care across …
View article: Dynamic DNA methylation turnover in gene bodies is associated with enhanced gene expression plasticity in plants
Dynamic DNA methylation turnover in gene bodies is associated with enhanced gene expression plasticity in plants Open
Background In several eukaryotes, DNA methylation occurs within the coding regions of many genes, termed gene body methylation (GbM). Whereas the role of DNA methylation on the silencing of transposons and repetitive DNA is well understood…
View article: Additional file 1 of Dynamic DNA methylation turnover in gene bodies is associated with enhanced gene expression plasticity in plants
Additional file 1 of Dynamic DNA methylation turnover in gene bodies is associated with enhanced gene expression plasticity in plants Open
Additional file 1. A list of Dynamic GbM and Stable GbM genes identified in this study.
View article: Corrigendum: Interference between ER stress-related bZIP-type and jasmonate-inducible bHLH-type transcription factors in the regulation of triterpene saponin biosynthesis in Medicago truncatula
Corrigendum: Interference between ER stress-related bZIP-type and jasmonate-inducible bHLH-type transcription factors in the regulation of triterpene saponin biosynthesis in Medicago truncatula Open
[This corrects the article DOI: 10.3389/fpls.2022.903793.].
View article: Dynamic DNA methylation turnover in gene bodies is associated with enhanced gene expression plasticity in plants
Dynamic DNA methylation turnover in gene bodies is associated with enhanced gene expression plasticity in plants Open
Background In several eukaryotes, DNA methylation occurs within the coding regions of many genes, termed gene body methylation (GbM). Whereas the role of DNA methylation on the silencing of transposons and repetitive DNA is well understood…
View article: Interference between ER stress-related bZIP-type and jasmonate-inducible bHLH-type transcription factors in the regulation of triterpene saponin biosynthesis in Medicago truncatula
Interference between ER stress-related bZIP-type and jasmonate-inducible bHLH-type transcription factors in the regulation of triterpene saponin biosynthesis in Medicago truncatula Open
Triterpene saponins (TS) are a structurally diverse group of metabolites that are widely distributed in plants. They primarily serve as defense compounds and their production is often triggered by biotic stresses through signaling cascades…
View article: LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples
LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples Open
Clinical and surveillance testing for the SARS-CoV-2 virus relies overwhelmingly on RT-qPCR-based diagnostics, yet several popular assays require 2–3 separate reactions or rely on detection of a single viral target, which adds significant …
View article: LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples
LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples Open
Clinical and surveillance testing for the SARS-CoV-2 virus relies overwhelmingly on RT-qPCR-based diagnostics, yet several popular assays require 2–3 separate reactions or rely on detection of a single viral target, which adds significant …
View article: STATE LIABILITY FOR FINAL COURT ORDERS SOUNDING IN MONEY: AT LONG LAST ALIGNMENT WITH THE CONSTITUTION
STATE LIABILITY FOR FINAL COURT ORDERS SOUNDING IN MONEY: AT LONG LAST ALIGNMENT WITH THE CONSTITUTION Open
Since the commencement of the State Liability Act 20 of 1957 the (until 2011) prevailing legislation rendered it almost impossible to satisfy judgment debts sounding in money against the State. There has been a continuous struggle in South…
View article: IGI-LuNER: single-well multiplexed RT-qPCR test for SARS-CoV-2
IGI-LuNER: single-well multiplexed RT-qPCR test for SARS-CoV-2 Open
Commonly used RT-qPCR-based SARS-CoV-2 diagnostics require 2-3 separate reactions or rely on detection of a single viral target, adding time and cost or risk of false-negative results. Currently, no test combines detection of widely used S…
View article: ER-Anchored Transcription Factors bZIP17 and bZIP60 Regulate Triterpene Saponin Biosynthesis in<i>Medicago truncatula</i><sup>1[OPEN]</sup>
ER-Anchored Transcription Factors bZIP17 and bZIP60 Regulate Triterpene Saponin Biosynthesis in<i>Medicago truncatula</i><sup>1[OPEN]</sup> Open
Triterpene saponins (TS) are a structurally diverse group of metabolites that are widely distributed in plants. They primarily serve as defense compounds and their production is often triggered by biotic stresses through signaling cascades…
View article: A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis
A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis Open
The cambium and procambium generate the majority of biomass in vascular plants. These meristems constitute a bifacial stem cell population from which xylem and phloem are specified on opposing sides by positional signals. The PHLOEM INTERC…
View article: Jasmonate and auxin perception: how plants keep F-boxes in check
Jasmonate and auxin perception: how plants keep F-boxes in check Open
Phytohormones regulate the plasticity of plant growth and development, and responses to biotic and abiotic stresses. Many hormone signal transduction cascades involve ubiquitination and subsequent degradation of proteins by the 26S proteas…
A Dual sgRNA Approach for Functional Genomics in <i>Arabidopsis thaliana</i> Open
Reverse genetics uses loss-of-function alleles to interrogate gene function. The advent of CRISPR/Cas9-based gene editing now allows the generation of knock-out alleles for any gene and entire gene families. Even in the model plant Arabido…
View article: A dual sgRNA approach for functional genomics in<i>Arabidopsis thaliana</i><sup>[OPEN]</sup>
A dual sgRNA approach for functional genomics in<i>Arabidopsis thaliana</i><sup>[OPEN]</sup> Open
Reverse genetics uses loss-of-function alleles to interrogate gene function. The advent of CRISPR/Cas9-based gene editing now allows to generate knock-out alleles for any gene and entire gene families. Even in the model plant Arabidopsis t…
View article: Rural Development within the Context of Development, Sustainability and Rural Issues – Some Constitutional, Policy and Implementation Perspectives
Rural Development within the Context of Development, Sustainability and Rural Issues – Some Constitutional, Policy and Implementation Perspectives Open
This article provides an overview of some developments, internationally, regionally and in the SADC, in relation to development, that may be expected to influence the South African government’s response to the development needs of the peop…
View article: Maccsand (Pty) Ltd v City of Cape Town 2012 (4) SA 181 (CC)
Maccsand (Pty) Ltd v City of Cape Town 2012 (4) SA 181 (CC) Open
The Constitutional Court in Maccsand (Pty) Ltd v City of Cape Town (CCT 103/11) 2012 ZACC 7 decided that the granting of mining rights or mining permits by the Minister of Mineral Resources in terms of the Mineral and Petroleum Resources D…
View article: Competing Preferent Community Prospecting Rights: A Nonchalant Custodian?
Competing Preferent Community Prospecting Rights: A Nonchalant Custodian? Open
Traditional communities that were precluded from the benefits and financial rewards of exploitation of the mineral resources of South Africa are afforded the opportunity to lodge an application with the Department of Mineral Resources (her…
View article: Competing Preferent Community Prospecting Rights: A Nonchalant Custodian?
Competing Preferent Community Prospecting Rights: A Nonchalant Custodian? Open
\n\t\t\t\t\tTraditional communities that were precluded from the benefits and financial rewards of exploitation of the mineral resources of South Africa are afforded the opportunity to lodge an application with the Department of Mineral Re…
View article: A brief history of the TDIF‐PXY signalling module: balancing meristem identity and differentiation during vascular development
A brief history of the TDIF‐PXY signalling module: balancing meristem identity and differentiation during vascular development Open
Summary A significant proportion of terrestrial biomass is constituted of xylem cells that make up woody plant tissue. Xylem is required for water transport, and is present in the vascular tissue with a second conductive tissue, phloem, re…