Clare E. Mackay
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View article: Multimodal MRI reveals distinct patterns of vascular and microstructural disruption across disease stages in the Oxford Brain Health Clinic
Multimodal MRI reveals distinct patterns of vascular and microstructural disruption across disease stages in the Oxford Brain Health Clinic Open
Background The Oxford Brain Health Clinic (OBHC) has assessed over 300 NHS memory clinic patients with a magnetic resonance imaging (MRI) protocol aligned with the UK Biobank. We also acquired the same data from over 100 healthy volunteers…
View article: Evaluating the impact of the Oxford Brain Health Clinic pathway on psychiatrists' confidence in diagnosing memory disorders, and their perceived assessment usefulness
Evaluating the impact of the Oxford Brain Health Clinic pathway on psychiatrists' confidence in diagnosing memory disorders, and their perceived assessment usefulness Open
Background The Oxford Brain Health Clinic (OBHC) was launched in August 2020 to provide enhanced assessments for memory clinic patients including MRI, advanced cognitive and lifestyle assessments, and optional research assessments. This st…
View article: A patient‐centred approach to translate remote cognitive assessments into clinical practice
A patient‐centred approach to translate remote cognitive assessments into clinical practice Open
Background Despite a proliferation of computerised and remote monitoring assessments offering opportunities to provide valuable data to researchers and clinicians, there are significant concerns about feasibility of such tools within a cli…
View article: Characterisation of long‐term conditions in a memory clinic population: A UK Biobank comparison study
Characterisation of long‐term conditions in a memory clinic population: A UK Biobank comparison study Open
Background Multimorbidity across the lifespan, especially during critical age windows, is associated with increased dementia risk. In this study, we sought to characterise the accumulation of long‐term conditions (LTCs) in a real‐world mem…
View article: A patient‐centred approach to translate remote cognitive assessments into clinical practice
A patient‐centred approach to translate remote cognitive assessments into clinical practice Open
Background Despite a proliferation of computerised and remote monitoring assessments offering opportunities to provide valuable data to researchers and clinicians, there are significant concerns about feasibility of such tools within a cli…
View article: The mediating role of shame in the relationship between adolescent hairpulling and co‐occurring anxiety and depressive symptomology
The mediating role of shame in the relationship between adolescent hairpulling and co‐occurring anxiety and depressive symptomology Open
Background Hairpulling (HP) is a body‐focused repetitive behaviour that typically begins in early adolescence. However, most research on HP has focused on adults, with large gaps in our understanding of the phenomenology and mechanisms inv…
View article: Compulsivity is associated with accelerated stimulus- response habit learning
Compulsivity is associated with accelerated stimulus- response habit learning Open
A prominent theory suggests that clinically significant compulsive behaviours arisefrom an overexpression of the brain’s habit system. However, most evidence for thiscomes indirectly – observing reduced goal directed or ‘model-based’ contr…
View article: Altered oscillatory coupling reflects possible inhibitory interneuron dysfunction in Rett syndrome
Altered oscillatory coupling reflects possible inhibitory interneuron dysfunction in Rett syndrome Open
Rett syndrome is a rare neurodevelopmental disorder caused primarily by pathogenic variants in the MECP2 gene, leading to lifelong cognitive impairments. To understand the broad neural disruptions in Rett syndrome, it is essential to exami…
View article: Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson’s disease revealed by in vivo PET imaging
Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson’s disease revealed by in vivo PET imaging Open
We conducted PET imaging with [ 18 F]FDOPA and dopamine D2/3 receptor ligand [ 18 F]fallypride in aged transgenic rats carrying human pathogenic LRRK2 R1441C or G2019S mutations. These rats have mild age-dependent deficits in dopamine rele…
View article: Evaluating Traditional, Deep Learning and Subfield Methods for Automatically Segmenting the Hippocampus From <scp>MRI</scp>
Evaluating Traditional, Deep Learning and Subfield Methods for Automatically Segmenting the Hippocampus From <span>MRI</span> Open
Given the relationship between hippocampal atrophy and cognitive impairment in various pathological conditions, hippocampus segmentation from MRI is an important task in neuroimaging. Manual segmentation, though considered the gold standar…
View article: From Big Data to the Clinic: Methodological and Statistical Enhancements to Implement the <scp>UK</scp> Biobank Imaging Framework in a Memory Clinic
From Big Data to the Clinic: Methodological and Statistical Enhancements to Implement the <span>UK</span> Biobank Imaging Framework in a Memory Clinic Open
The analysis tools and statistical methods used in large neuroimaging research studies differ from those applied in clinical contexts, making it unclear whether these techniques can be translated to a memory clinic setting. The Oxford Brai…
View article: Neuroimaging-based data-driven subtypes of spatiotemporal atrophy due to Parkinson’s disease
Neuroimaging-based data-driven subtypes of spatiotemporal atrophy due to Parkinson’s disease Open
Parkinson’s disease is the second most common neurodegenerative disease. Despite this, there are no robust biomarkers to predict progression, and understanding of disease mechanisms is limited. We used the Subtype and Stage Inference algor…
View article: Automated quality control of T1-weighted brain MRI scans for clinical research datasets: methods comparison and design of a quality prediction classifier
Automated quality control of T1-weighted brain MRI scans for clinical research datasets: methods comparison and design of a quality prediction classifier Open
T1-weighted (T1w) MRI is widely used in clinical neuroimaging for studying brain structure and its changes, including those related to neurodegenerative diseases, and as anatomical reference for analysing other modalities. Ensuring high-qu…
View article: The lifetime accumulation of multimorbidity and its influence on dementia risk: a UK Biobank study
The lifetime accumulation of multimorbidity and its influence on dementia risk: a UK Biobank study Open
The number of people living with dementia worldwide is projected to reach 150 million by 2050, making prevention a crucial priority for health services. The co-occurrence of two or more chronic health conditions, termed multimorbidity, occ…
View article: Associations between Later‐life Cerebrovascular Reactivity and Brain Structure and Cognitive Decline: A Longitudinal Study in an Aging Cohort with Varying Dementia Risks
Associations between Later‐life Cerebrovascular Reactivity and Brain Structure and Cognitive Decline: A Longitudinal Study in an Aging Cohort with Varying Dementia Risks Open
Background Cerebrovascular reactivity (CVR) is implicated in the progression of dementia, though the underlying mechanisms is not understood. This study examines the relationships between CVR and brain structure and cognitive decline, mode…
View article: Prevalence of dementia risk factors in a memory clinic setting: The Oxford Brain Health Clinic
Prevalence of dementia risk factors in a memory clinic setting: The Oxford Brain Health Clinic Open
With promising disease-modifying therapies (DMTs) emerging and good evidence to support risk reduction in the delay of dementia onset and progression, it is important to understand the profile of patients attending memory assessment servic…
View article: Is Your Style Transfer Doing Anything Useful? An Investigation Into Hippocampus Segmentation and the Role of Preprocessing
Is Your Style Transfer Doing Anything Useful? An Investigation Into Hippocampus Segmentation and the Role of Preprocessing Open
Brain atrophy assessment in MRI, particularly of the hippocampus, is commonly used to support diagnosis and monitoring of dementia. Consequently, there is a demand for accurate automated hippocampus quantification. Most existing segmentati…
View article: Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild Traumatic Brain Injury in the PREVENT Dementia Study
Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild Traumatic Brain Injury in the PREVENT Dementia Study Open
Importance Traumatic brain injuries (TBI) represent an important, potentially modifiable risk factor for dementia. Despite frequently observed vascular imaging changes in individuals with TBI, the relationships between TBI-associated chang…
View article: A worldwide study of white matter microstructural alterations in people living with Parkinson’s disease
A worldwide study of white matter microstructural alterations in people living with Parkinson’s disease Open
The progression of Parkinson's disease (PD) is associated with microstructural alterations in neural pathways, contributing to both motor and cognitive decline. However, conflicting findings have emerged due to the use of heterogeneous met…
View article: Evaluating Traditional, Deep Learning, and Subfield Methods for Automatically Segmenting the Hippocampus from MRI
Evaluating Traditional, Deep Learning, and Subfield Methods for Automatically Segmenting the Hippocampus from MRI Open
Given the relationship between hippocampal atrophy and cognitive impairment in various pathological conditions, hippocampus segmentation from MRI is an important task in neuroimaging. Manual segmentation, though considered the gold standar…
View article: From Big Data to the clinic: methodological and statistical enhancements to implement the UK Biobank imaging framework in a memory clinic
From Big Data to the clinic: methodological and statistical enhancements to implement the UK Biobank imaging framework in a memory clinic Open
Introduction The analysis tools and statistical methods used in large neuroimaging research studies differ from those applied in clinical contexts, making it unclear whether these techniques can be translated to a memory clinic setting. Th…
View article: Resting-state networks and anosognosia in Alzheimer’s disease
Resting-state networks and anosognosia in Alzheimer’s disease Open
Background Recent evidence suggests that anosognosia or unawareness of cognitive impairment in Alzheimer’s Disease (AD) may be explained by a disconnection between brain regions involved in accessing and monitoring information regarding se…
View article: Automated quality control of T1-weighted brain MRI scans for clinical research: methods comparison and design of a quality prediction classifier
Automated quality control of T1-weighted brain MRI scans for clinical research: methods comparison and design of a quality prediction classifier Open
Introduction T1-weighted MRI is widely used in clinical neuroimaging for studying brain structure and its changes, including those related to neurodegenerative diseases, and as anatomical reference for analysing other modalities. Ensuring …
View article: The lifetime accumulation of multimorbidity and its influence on dementia risk: a UK Biobank Study
The lifetime accumulation of multimorbidity and its influence on dementia risk: a UK Biobank Study Open
The number of people living with dementia worldwide is projected to reach 150 million by 2050, making prevention a crucial priority for health services 1 . The co-occurrence of two or more chronic health conditions, termed multimorbidity, …
View article: A Worldwide Study of White Matter Microstructural Alterations in People Living with Parkinson’s Disease
A Worldwide Study of White Matter Microstructural Alterations in People Living with Parkinson’s Disease Open
Background The progression of Parkinson’s disease (PD) is associated with microstructural alterations in neural pathways, contributing to both motor and cognitive decline. However, conflicting findings have emerged due to the use of hetero…