Clare L. Newell
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View article: Orbitrap noise structure and method for noise unbiased multivariate analysis
Orbitrap noise structure and method for noise unbiased multivariate analysis Open
Orbitrap mass spectrometry is widely used in the life-sciences. However, like all mass spectrometers, non-uniform (heteroscedastic) noise introduces bias in multivariate analysis complicating data interpretation. Here, we study the noise s…
View article: An intercellular metabolic relay for brain sparing in <i>Drosophila</i>
An intercellular metabolic relay for brain sparing in <i>Drosophila</i> Open
Brain sparing protects growth of the central nervous system (CNS) at the expense of other developing organs during nutrient restriction. This survival strategy is conserved from Drosophila to mammals but little is known about its underlyin…
View article: Identification of a specialized lipid barrier for<i>Drosophila</i>metamorphosis
Identification of a specialized lipid barrier for<i>Drosophila</i>metamorphosis Open
In many terrestrial insects, the onset of metamorphosis marks a transition from humid to dry environments. Yet how metamorphosing insect pupae protect themselves against the threat of dehydration remains unclear. Here, we identify the chem…
View article: Orbitrap noise structure and method for noise-unbiased multivariate analysis
Orbitrap noise structure and method for noise-unbiased multivariate analysis Open
Orbitrap mass spectrometry is widely used in the life-sciences. However, like all mass spectrometers, non-uniform (heteroscedastic) noise introduces bias in multivariate analysis complicating data interpretation. Here, we study the noise s…
View article: Cryogenic OrbiSIMS Localizes Semi‐Volatile Molecules in Biological Tissues
Cryogenic OrbiSIMS Localizes Semi‐Volatile Molecules in Biological Tissues Open
OrbiSIMS is a recently developed instrument for label‐free imaging of chemicals with micron spatial resolution and high mass resolution. We report a cryogenic workflow for OrbiSIMS (Cryo‐OrbiSIMS) that improves chemical detection of lipids…
View article: Cryogenic OrbiSIMS Localizes Semi‐Volatile Molecules in Biological Tissues
Cryogenic OrbiSIMS Localizes Semi‐Volatile Molecules in Biological Tissues Open
OrbiSIMS is a recently developed instrument for label‐free imaging of chemicals with micron spatial resolution and high mass resolution. We report a cryogenic workflow for OrbiSIMS (Cryo‐OrbiSIMS) that improves chemical detection of lipids…
View article: Cryogenic OrbiSIMS Localizes Semi-Volatile Molecules in Biological Tissues
Cryogenic OrbiSIMS Localizes Semi-Volatile Molecules in Biological Tissues Open
OrbiSIMS is a recently developed instrument for label-free imaging of chemicals with micron spatial resolution and high mass resolution. Here we report a cryogenic workflow for OrbiSIMS (Cryo-OrbiSIMS) that improves chemical detection of l…
View article: Protein CoAlation and antioxidant function of coenzyme A in prokaryotic cells
Protein CoAlation and antioxidant function of coenzyme A in prokaryotic cells Open
In all living organisms, coenzyme A (CoA) is an essential cofactor with a unique design allowing it to function as an acyl group carrier and a carbonyl-activating group in diverse biochemical reactions. It is synthesized in a highly conser…
View article: Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells
Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells Open
Coenzyme A (CoA) is an obligatory cofactor in all branches of life. CoA and its derivatives are involved in major metabolic pathways, allosteric interactions and the regulation of gene expression. Abnormal biosynthesis and homeostasis of C…