Clare M. Lloyd
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View article: Single-Cell RNA-seq Reveals Aberrant Airway Epithelial-Immune Cell Crosstalk In Pulmonary Fibrosis
Single-Cell RNA-seq Reveals Aberrant Airway Epithelial-Immune Cell Crosstalk In Pulmonary Fibrosis Open
Background Epithelial-immune cell interactions are crucial in the regulation of pulmonary immune responses. Emerging evidence suggests that cell populations lining the airways may play a pivotal role in the pathogenesis of idiopathic pulmo…
View article: OA28 Really... gout?! An unexpected diagnosis of gout in the wrist of a 12-year-old girl
OA28 Really... gout?! An unexpected diagnosis of gout in the wrist of a 12-year-old girl Open
Introduction Gout is a common form of inflammatory arthritis in adults but is rare in children and adolescents. Few studies have examined paediatric gout. There are no treatment pathways for the disease. The term gout refers to a collectio…
View article: Protective Role for Itaconate During Inhaled Allergen Challenge
Protective Role for Itaconate During Inhaled Allergen Challenge Open
Background Asthma is a chronic, heterogeneous disease characterised by airway remodelling, inflammation, and mucus production. Airway macrophages' functions are underpinned by changes in cellular metabolism. The TCA cycle‐derived metabolit…
View article: Bacterial communities co-develop with respiratory immunity early in life, linking dysbiosis to systemic monocyte signature and wheezing
Bacterial communities co-develop with respiratory immunity early in life, linking dysbiosis to systemic monocyte signature and wheezing Open
Early microbial colonization influences respiratory disease risk, yet mechanisms remain unclear. In a prospective birth cohort of 256 infants, we profiled bacterial, fungal, and viral communities in the upper airway and assessed local immu…
View article: T follicular helper cells drive functionally distinct lymphoid and lung resident germinal centres and limit allergic airway disease
T follicular helper cells drive functionally distinct lymphoid and lung resident germinal centres and limit allergic airway disease Open
T follicular helper cells (TFH) play a central role in orchestrating antibody mediated immunity. Despite the importance of antibody responses, especially allergen-specific IgE, in allergic airway diseases (AAD) such as asthma, t…
View article: Where are my Black professors? The research culture preventing Black researchers from thriving in UK institutions
Where are my Black professors? The research culture preventing Black researchers from thriving in UK institutions Open
This paper investigates the persistent underrepresentation of Black heritage researchers and academics at UK Higher Education Institutions in Science, Technology, Engineering, Maths, and Medicine (STEMM), with a focus on Biomedical Researc…
View article: Epithelial cell derived lumican modulates extracellular matrix dynamics in early-life airways disease
Epithelial cell derived lumican modulates extracellular matrix dynamics in early-life airways disease Open
We demonstrate a previously uncharacterized role of collagen-associated phenotypic and geometric changes in early-life airway remodeling and show lumican as a crucial remodeling factor associated with collagen organization in PSW and SA.
View article: Investigating the lasting effects of SARS-CoV-2 infection and the lung microbiota: No persistent microbial alterations in recovered COVID-19 patients with persistent radiological or respiratory abnormalities.
Investigating the lasting effects of SARS-CoV-2 infection and the lung microbiota: No persistent microbial alterations in recovered COVID-19 patients with persistent radiological or respiratory abnormalities. Open
SARS-CoV-2 was a global pandemic where infected individuals experienced mild or severe disease. Unfortunately, some patients who experienced severe disease also had lasting abnormalities. The lung microbiota of thirty-eight adult COVID-19 …
View article: A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma
A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma Open
Determining spatial location of cells within tissues gives vital insight into the interactions between resident and inflammatory cells and is a critical factor for uncoupling the mechanisms driving disease. Here, we apply single-cell spati…
View article: Location, Location, Location: Spatial Immune‐Stroma Crosstalk Drives Pathogenesis in Asthma
Location, Location, Location: Spatial Immune‐Stroma Crosstalk Drives Pathogenesis in Asthma Open
Chronic lung diseases including asthma are characterized by an abnormal immune response and active tissue remodeling. These changes in the architecture of the tissue are a fundamental part of the pathology across the life course of patient…
View article: Differentiation of human T follicular helper cells<i>in vitro</i>requires co-operation between STAT3 and SMAD signaling cytokines that is restrained by IL-2
Differentiation of human T follicular helper cells<i>in vitro</i>requires co-operation between STAT3 and SMAD signaling cytokines that is restrained by IL-2 Open
T follicular helper cells (TFH) are a CD4 T cell subset required for effective humoral immunity; promoting antibody responses to vaccines and natural infections. The mechanisms by which human TFH differentiate are not fully understood, and…
View article: Mechanistic modelling of allergen-induced airways disease in early life
Mechanistic modelling of allergen-induced airways disease in early life Open
Asthma affects approximately 300 million individuals worldwide and the onset predominantly arises in childhood. Children are exposed to multiple environmental irritants, such as viruses and allergens, that are common triggers for asthma on…
View article: The respiratory microbiome in patients with post-COVID-19 residual lung abnormalities resembles that of healthy individuals and is distinct from idiopathic pulmonary fibrosis
The respiratory microbiome in patients with post-COVID-19 residual lung abnormalities resembles that of healthy individuals and is distinct from idiopathic pulmonary fibrosis Open
Introduction Up to 11% of patients are left with residual lung abnormalities following COVID-19 infection. It is unclear whether these changes resolve over time or progress to fibrosis. The airway microbiome is altered in interstitial lung…
View article: Basophils: Regulators of lung inflammation over space and time
Basophils: Regulators of lung inflammation over space and time Open
In this issue of JEM, Schuijs et al. (https://doi.org/10.1084/jem.20240103) highlight a novel role for basophils during allergic immune responses to house dust mites (HDM). They reveal that interleukin-33 (IL-33)-activated basophils facili…
View article: Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen
Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen Open
View article: Deep multiomic profiling reveals molecular signatures that underpin preschool wheeze and asthma
Deep multiomic profiling reveals molecular signatures that underpin preschool wheeze and asthma Open
These factors highlighted distinctions between an inflammation-related phenotype in preschool wheeze, and the predominance of airway epithelial-related changes linked with the inferred trajectory toward asthma. These findings provide insig…
View article: Airway extracellular LTA4H concentrations are governed by release from liver hepatocytes and changes in lung vascular permeability
Airway extracellular LTA4H concentrations are governed by release from liver hepatocytes and changes in lung vascular permeability Open
Leukotriene A4 hydrolase (LTA4H) is a bifunctional enzyme, with dual activities critical in defining the scale of tissue inflammation and pathology. LTA4H classically operates intracellularly, primarily wit…
View article: Mast cell activation disrupts interactions between endothelial cells and pericytes during early life allergic asthma
Mast cell activation disrupts interactions between endothelial cells and pericytes during early life allergic asthma Open
Allergic asthma generally starts during early life and is linked to substantial tissue remodeling and lung dysfunction. Although angiogenesis is a feature of the disrupted airway, the impact of allergic asthma on the pulmonary microcircula…
View article: Correction to “Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge”
Correction to “Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge” Open
Dear Editors, The detection of specialist pro-resolving mediators has recently been the subject of discussion in the literature. In our study in 2015,1 we published the detection of lipoxin A2 (LXA4) in mouse lung homogenate following hous…
View article: Airway Extracellular LTA4H Concentrations are Governed by Release From Liver Hepatocyte and Changes in Lung Vascular Permeability
Airway Extracellular LTA4H Concentrations are Governed by Release From Liver Hepatocyte and Changes in Lung Vascular Permeability Open
View article: Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis
Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis Open
Aberrant expansion of KRT5 + basal cells in the distal lung accompanies progressive alveolar epithelial cell loss and tissue remodelling during fibrogenesis in idiopathic pulmonary fibrosis (IPF). The mechanisms determining activity of KRT…
View article: A conversation on allergy: recognizing the past and looking to the future
A conversation on allergy: recognizing the past and looking to the future Open
Allergy is an ever‐evolving group of disorders, which includes asthma, atopic dermatitis, rhinitis and food allergies and that currently affects over 1 billion people worldwide. This group of disorders has exploded in incidence since aroun…
View article: A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing
A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing Open
Background: Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used a broad definition of ‘doctor-diagnosed asthma’, thereby diluting genetic signals by not consideri…
View article: Author response: A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing
Author response: A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing Open
Full text Figures and data Side by side Abstract Editor's evaluation eLife digest Introduction Materials and methods Results Discussion Appendix 1 Appendix 2 Appendix 3 Appendix 4 Appendix 5 Appendix 6 Data availability References Decision…
View article: T helper 2 cells in asthma
T helper 2 cells in asthma Open
Allergic asthma is among the most common immune-mediated diseases across the world, and type 2 immune responses are thought to be central to pathogenesis. The importance of T helper 2 (Th2) cells as central regulators of type 2 responses i…
View article: Immunoregulation of asthma by type 2 cytokine therapies: Treatments for all ages?
Immunoregulation of asthma by type 2 cytokine therapies: Treatments for all ages? Open
Asthma is classically considered to be a disease of type 2 immune dysfunction, since many patients exhibit the consequences of excess secretion of cytokines such as IL‐4, IL‐5, and IL‐13 concomitant with inflammation typified by eosinophil…
View article: Mast cell activation disrupts interactions between endothelial cells and pericytes during early life allergic asthma
Mast cell activation disrupts interactions between endothelial cells and pericytes during early life allergic asthma Open
Allergic asthma generally starts during early life and is linked to substantial tissue remodelling and lung dysfunction. Although angiogenesis is a feature of the disrupted airway, the impact of allergic asthma on the pulmonary microcircul…
View article: A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies <i>ANXA1</i> as a susceptibility locus for persistent wheezing
A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies <i>ANXA1</i> as a susceptibility locus for persistent wheezing Open
Background Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used a broad definition of “doctor-diagnosed asthma”, thereby diluting genetic signals by not considerin…
View article: Adventitial Mast Cell Activation Disrupts Endothelial Cell/Pericyte Interactions During Early Life Allergic Asthma
Adventitial Mast Cell Activation Disrupts Endothelial Cell/Pericyte Interactions During Early Life Allergic Asthma Open
View article: Lung extracellular matrix modulates KRT5<sup>+</sup>basal cell activity in pulmonary fibrosis
Lung extracellular matrix modulates KRT5<sup>+</sup>basal cell activity in pulmonary fibrosis Open
Aberrant expansion of KRT5 + basal cells in the distal lung accompanies progressive alveolar epithelial cell loss and tissue remodelling during fibrogenesis in idiopathic pulmonary fibrosis (IPF). The mechanisms determining activity of KRT…