Clare Tower
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Digital Assessment of Wellbeing in New Parents (DAWN-P): protocol of a randomised feasibility trial comparing digital screening for maternal postnatal depression with usual care screening Open
Background Meta-analyses indicate that 17% of mothers experience postnatal depression (PND) in the year following childbirth, with suicide the leading cause of direct maternal death between 6 weeks and 12 months postpartum. The consequence…
Interest and barriers to research in obstetric haematology – findings from a national survey in the United Kingdom Open
Introduction In 2021, the steering committee members of British Society of Haematology Obstetric Haematology Special Interest Group noted difficulties in opening research studies. This led to the development of a survey to further evaluate…
Fertility Trends and Adverse Pregnancy Outcomes in Female Patients With Psoriasis in the UK Open
Importance Evidence regarding fertility trends and obstetric outcomes among patients with psoriasis is limited by studies of small sample sizes, noninclusion of comparators, and the lack of accurate pregnancy records. Objective To investig…
A successful antenatal outcome in a patient with refractory Takayasu’s arteritis treated with tocilizumab throughout pregnancy—a case report Open
Takayasu’s arteritis (TA) is a rare form of large-vessel vasculitis for which tocilizumab (TCZ) may be administered in resistant or refractory disease. Current British Society of Rheumatology advice is to stop TCZ 3-months pre-conception. …
British Society for Haematology guideline for anticoagulant management of pregnant individuals with mechanical heart valves Open
Evidence is limited regarding the prevalence and optimal management of pregnancy in individuals with mechanical heart valves (MHVs). Studies are scarce, often with small numbers of patients included. Mechanical valve thrombosis (MVT) occur…
Pregnancy outcomes of a joint obstetric and rheumatology clinic in a tertiary centre: a 2-year retrospective study of 98 pregnancies Open
Objectives The purpose of this study was to describe the maternal and fetal outcomes in patients with inflammatory rheumatic diseases attending a joint rheumatology and obstetric clinic in the UK. Methods Electronic records of 98 patients …
Immunomodulatory Therapy Reduces the Severity of Placental Lesions in Chronic Histiocytic Intervillositis Open
Chronic histiocytic intervillositis (CHI) is a rare, but highly recurrent inflammatory placental lesion wherein maternal macrophages infiltrate the intervillous space. Pregnancies with CHI are at high risk of fetal growth restriction, misc…
Multidisciplinary management of pregnancy and labour in a patient with glycogen storage disease type 1a Open
Glycogen storage disease type 1a (GSD 1a) is a metabolic disorder caused by deficiency of an enzyme required for glycogen breakdown, causing hypoglycaemia and lactic acidosis. Metabolic derangements cause disease manifestations affecting t…
Adverse pregnancy outcomes and subsequent development of connective tissue disease in the UK: an epidemiological study Open
Objective This study assessed prevalence of connective tissue disease (CTDs), systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS) and antiphospholipid antibodies (aPL) in women with previous adverse pregnancy outcome compar…
Delineating differential regulatory signatures of the human transcriptome in the choriodecidua and myometrium at term labor†,‡ Open
Preterm deliveries remain the leading cause of neonatal morbidity and mortality. Current therapies target only myometrial contractions and are largely ineffective. As labor involves multiple coordinated events across maternal and fetal tis…
Management of pregnancy in type 3 von Willebrand disease with alloantibodies Open
Type 3 von Willebrand disease (VWD) is the most severe sub-type of VWD, characterised by the almost complete absence of von Willebrand factor (VWF) and profoundly reduced levels of factor VIII (FVIII). Treatment consists of normalisation o…
Antenatal thoracoamniotic shunting in congenital cystic adenomatoid malformation Open
This case report describes a baby who was diagnosed antenatally with a significant left-sided congenital cystic adenomatoid malformation.Following diagnosis of a fluid-filled, macrocystic structure on the left side of the chest, the mother…
Vitamin D status of White pregnant women and infants at birth and 4 months in North West England: A cohort study Open
The prevalence of vitamin D deficiency in pregnant white‐skinned women (WSW) and their infants has not been investigated at northern latitudes in a developed county. A 2‐year observational cohort study was undertaken in the North West of E…
View article: ‘To test or not to test’, the arguments for and against thrombophilia testing in obstetrics
‘To test or not to test’, the arguments for and against thrombophilia testing in obstetrics Open
Clinicians increasingly investigate women for thrombophilias due to their associations with venous thromboembolism and placenta-mediated pregnancy complication. These associations, however, are modest and based largely on retrospective dat…
Pregnancy outcomes in women with mechanical prosthetic heart valves: a prospective descriptive population based study using the United Kingdom Obstetric Surveillance System (<span>UKOSS</span>) data collection system Open
Objective To describe the incidence of mechanical prosthetic heart valves ( MPHV ) in pregnancy in the UK ; rates of maternal and fetal complications in this group of women, and whether these vary with the anticoagulation used during pregn…
Successful management of acute myeloid leukaemia in a twin pregnancy – a case report Open
Acute leukaemia affects approximately 1 in 75 000 pregnancies, the majority presenting with acute myeloid leukaemia (AML) (Caligiuri & Mayer, 1989). As twins account for 16 per 1000 pregnancies, the incidence of AML in twin pregnancies is …
View article: Management of inherited thrombophilia in pregnancy
Management of inherited thrombophilia in pregnancy Open
Adverse pregnancy outcomes, such as pregnancy loss and pre-eclampsia, are associated with thrombotic mechanisms and thrombophilia. Antithrombotic interventions, particularly low-molecular-weight heparin, have been investigated in women ide…