Clare Verrill
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View article: IGF-1 regulates cancer cell immune evasion in prostate cancer
IGF-1 regulates cancer cell immune evasion in prostate cancer Open
Insulin-like growth factor-1 (IGF-1) is associated with prostate cancer (PCa) development and lethality and exhibits immunosuppressive properties in other models. We investigated IGF-1’s tumor-intrinsic immune effects in PCa to understand …
View article: Exploring patient and clinician opinions, perspectives and acceptance of the use of artificial intelligence in the histological diagnosis of prostate cancer
Exploring patient and clinician opinions, perspectives and acceptance of the use of artificial intelligence in the histological diagnosis of prostate cancer Open
Objectives This study aims to explore the opinions and attitudes of patients and clinicians regarding the use of artificial intelligence (AI) in the diagnosis of prostate biopsies, with a focus on acceptance and trust in the use of AI, and…
View article: Detection of Genome‐Wide <scp>IGF</scp> ‐ <scp>1R</scp> Recruitment to Enhancer and Promoter Regions of Chromatin in Clinical Prostate Cancers
Detection of Genome‐Wide <span>IGF</span> ‐ <span>1R</span> Recruitment to Enhancer and Promoter Regions of Chromatin in Clinical Prostate Cancers Open
Introduction Nuclear insulin‐like growth factor‐1 receptor (IGF‐1R) undergoes IGF‐induced recruitment to cancer cell chromatin in vitro and associates with advanced prostate cancer (PCa) stage in clinical tissue, prompting this investigati…
View article: Tumor-specific CD8 T cell characterization in HR+ breast cancer reveals an impaired antitumoral response in patients with lymph node metastasis
Tumor-specific CD8 T cell characterization in HR+ breast cancer reveals an impaired antitumoral response in patients with lymph node metastasis Open
Most breast cancers express the estrogen receptor (ER), but the immune response of hormone receptor-positive (HR+) breast cancer remains poorly characterized. Here, dendritic cells loaded with tumor lysate are used to identify t…
View article: A deployment safety case for AI-assisted prostate cancer diagnosis
A deployment safety case for AI-assisted prostate cancer diagnosis Open
View article: Local anaesthetic transperineal biopsy versus transrectal prostate biopsy in prostate cancer detection (TRANSLATE): a multicentre, randomised, controlled trial
Local anaesthetic transperineal biopsy versus transrectal prostate biopsy in prostate cancer detection (TRANSLATE): a multicentre, randomised, controlled trial Open
National Institute for Health and Care Research (NIHR) Health Technology Assessment.
View article: Self-interactive learning: Fusion and evolution of multi-scale histomorphology features for molecular traits prediction in computational pathology
Self-interactive learning: Fusion and evolution of multi-scale histomorphology features for molecular traits prediction in computational pathology Open
Predicting disease-related molecular traits from histomorphology brings great opportunities for precision medicine. Despite the rich information present in histopathological images, extracting fine-grained molecular features from standard …
View article: Tumour purity assessment with deep learning in colorectal cancer and impact on molecular analysis
Tumour purity assessment with deep learning in colorectal cancer and impact on molecular analysis Open
Tumour content plays a pivotal role in directing the bioinformatic analysis of molecular profiles such as copy number variation (CNV). In clinical application, tumour purity estimation (TPE) is achieved either through visual pathological r…
View article: IGFs regulate cancer cell immune evasion in prostate cancer
IGFs regulate cancer cell immune evasion in prostate cancer Open
Insulin-like growth factor-1 (IGF-1) promotes prostate cancer (PCa) development and lethality, with immunosuppressive properties in other disease models. These studies investigated the tumor-intrinsic immune effects of IGF-1 in PCa to unde…
View article: Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project
Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project Open
View article: Prostate cancer detection after atypical small acinar proliferation (ASAP): A 10‐year single‐centre cohort
Prostate cancer detection after atypical small acinar proliferation (ASAP): A 10‐year single‐centre cohort Open
Atypical small acinar proliferation (ASAP), found in 5% of prostate biopsies, represents a focus of atypical cells that fall short of a cancer diagnosis.1 ASAP may be associated with a diagnosis of prostate cancer (PCa) upon repeat biopsy …
View article: First-in-man study of the PSMA Minibody IR800-IAB2M for molecularly targeted intraoperative fluorescence guidance during radical prostatectomy
First-in-man study of the PSMA Minibody IR800-IAB2M for molecularly targeted intraoperative fluorescence guidance during radical prostatectomy Open
Purpose Prostate-specific membrane antigen (PSMA) is increasingly used to image prostate cancer in clinical practice. We sought to develop and test a humanised PSMA minibody IAB2M conjugated to the fluorophore IRDye 800CW-NHS ester in men …
View article: Artificial Intelligence-Based Quality Assessment of Histopathology Whole-Slide Images within a Clinical Workflow: Assessment of ‘PathProfiler’ in a Diagnostic Pathology Setting
Artificial Intelligence-Based Quality Assessment of Histopathology Whole-Slide Images within a Clinical Workflow: Assessment of ‘PathProfiler’ in a Diagnostic Pathology Setting Open
Digital pathology continues to gain momentum, with the promise of artificial intelligence to aid diagnosis and for assessment of features which may impact prognosis and clinical management. Successful adoption of these technologies depends…
View article: Analysis of 3D pathology samples using weakly supervised AI
Analysis of 3D pathology samples using weakly supervised AI Open
View article: Everyday Diagnostic Work in the Histopathology Lab: CSCW Perspectives on the Utilization of Data-Driven Clinical Decision Support Systems
Everyday Diagnostic Work in the Histopathology Lab: CSCW Perspectives on the Utilization of Data-Driven Clinical Decision Support Systems Open
In this paper we present an ethnographic study of the work of histopathologists as they grapple with the twin innovations of transitioning to digital biopsy images and the prospective adoption of an AI-based clinical decision support syste…
View article: Molecular analysis of archival diagnostic prostate cancer biopsies identifies genomic similarities in cases with progression post‐radiotherapy, and those with de novo metastatic disease
Molecular analysis of archival diagnostic prostate cancer biopsies identifies genomic similarities in cases with progression post‐radiotherapy, and those with de novo metastatic disease Open
Background It is important to identify molecular features that improve prostate cancer (PCa) risk stratification before radical treatment with curative intent. Molecular analysis of historical diagnostic formalin‐fixed paraffin‐embedded (F…
View article: Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity
Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity Open
Cancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer treatments. In the past decade, CD103 + T cells have been associated with better clinica…
View article: PRAGMATIC - PRostate cancer diAGnosis and MAnagement – Triage In the Clinical care pathway
PRAGMATIC - PRostate cancer diAGnosis and MAnagement – Triage In the Clinical care pathway Open
Background It is important to investigate, diagnose and commence treatment for locally advanced and metastatic prostate cancer quickly to optimise treatment outcomes. Since the introduction of national 2-week wait and 31/62-day targets in …
View article: Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features
Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features Open
Background Extension of prostate cancer beyond the primary site by local invasion or nodal metastasis is associated with poor prognosis. Despite significant research on tumour evolution in prostate cancer metastasis, the emergence and evol…
View article: Engineering the future of <scp>3D</scp> pathology
Engineering the future of <span>3D</span> pathology Open
In recent years, technological advances in tissue preparation, high‐throughput volumetric microscopy, and computational infrastructure have enabled rapid developments in nondestructive 3D pathology, in which high‐resolution histologic data…
View article: Spatial transcriptomic analysis of virtual prostate biopsy reveals confounding effect of tissue heterogeneity on genomic signatures
Spatial transcriptomic analysis of virtual prostate biopsy reveals confounding effect of tissue heterogeneity on genomic signatures Open
Genetic signatures have added a molecular dimension to prognostics and therapeutic decision-making. However, tumour heterogeneity in prostate cancer and current sampling methods could confound accurate assessment. Based on previously publi…
View article: Beyond attention: deriving biologically interpretable insights from weakly-supervised multiple-instance learning models
Beyond attention: deriving biologically interpretable insights from weakly-supervised multiple-instance learning models Open
Recent advances in attention-based multiple instance learning (MIL) have improved our insights into the tissue regions that models rely on to make predictions in digital pathology. However, the interpretability of these approaches is still…
View article: Molecular analysis of archival diagnostic prostate cancer biopsies identifies genomic similarities in cases with progression post-radiotherapy, and those with<i>de novo</i>metastatic disease
Molecular analysis of archival diagnostic prostate cancer biopsies identifies genomic similarities in cases with progression post-radiotherapy, and those with<i>de novo</i>metastatic disease Open
Purpose It is important to identify molecular features that improve prostate cancer (PCa) risk stratification before radical treatment with curative intent. Molecular analysis of historical diagnostic formalin-fixed paraffin-embedded (FFPE…
View article: 953 Outcomes of Partial Nephrectomy for pT3a Renal Cell Cancer Over 20 Years at a Single Centre
953 Outcomes of Partial Nephrectomy for pT3a Renal Cell Cancer Over 20 Years at a Single Centre Open
Aim There is limited information on outcomes of pT3a RCC treated with PN. Retrospective studies of cT1/2 upstaged to pT3a treated with RN vs PN show contradictory results. Method Retrospective analysis of all pT3a renal tumours removed by …
View article: Genomic Evolution and Transcriptional Changes in the Evolution of Prostate Cancer into Neuroendocrine and Ductal Carcinoma Types
Genomic Evolution and Transcriptional Changes in the Evolution of Prostate Cancer into Neuroendocrine and Ductal Carcinoma Types Open
Prostate cancer is typically of acinar adenocarcinoma type but can occasionally present as neuroendocrine and/or ductal type carcinoma. These are associated with clinically aggressive disease, and the former often arises on a background of…
View article: Flexible and Highly-Efficient Feature Perception for Molecular Traits Prediction via Self-interactive Deep Learning
Flexible and Highly-Efficient Feature Perception for Molecular Traits Prediction via Self-interactive Deep Learning Open
Predicting disease-related molecular traits from histomorphology brings great opportunities for precision medicine. Despite the rich information present in histopathological images, extracting fine-grained molecular features from standard …
View article: Department Wide Validation in Digital Pathology—Experience from an Academic Teaching Hospital Using the UK Royal College of Pathologists’ Guidance
Department Wide Validation in Digital Pathology—Experience from an Academic Teaching Hospital Using the UK Royal College of Pathologists’ Guidance Open
Aim: we describe our experience of validating departmental pathologists for digital pathology reporting, based on the UK Royal College of Pathologists (RCPath) “Best Practice Recommendations for Implementing Digital Pathology (DP),” at a l…
View article: Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models
Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models Open
View article: Movie S2 from Self-Maintaining CD103<sup>+</sup> Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses
Movie S2 from Self-Maintaining CD103<sup>+</sup> Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses Open
Movie S2 shows CD103+ T cell killing HCT116 cancer cell, by calcium flux imaging.
View article: Data from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
Data from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses Open
Immunotherapy treatments with anti-PD-1 boost recovery in less than 30% of treated cancer patients, indicating the complexity of the tumor microenvironment. Expression of HLA-E is linked to poor clinical outcomes in mice and human patients…