Clarissa Pilkington
YOU?
Author Swipe
View article: P132 Refractory culture-negative arthritis and systemic inflammation in a child with sickle cell disease: a diagnostic and therapeutic challenge
P132 Refractory culture-negative arthritis and systemic inflammation in a child with sickle cell disease: a diagnostic and therapeutic challenge Open
Introduction Systemic inflammation in children with sickle cell disease (SCD) presents diagnostic challenges, as overlapping features of vaso-occlusive crises, infection, and potential autoinflammatory processes can be difficult to disting…
View article: Item selection for the development and validation of a revised classification criteria for adult and juvenile idiopathic inflammatory myopathies: MyoROC project
Item selection for the development and validation of a revised classification criteria for adult and juvenile idiopathic inflammatory myopathies: MyoROC project Open
The new items that will be tested in the revised criteria were generated with input from a wide range of stakeholders and included, most importantly, MSA, pattern of weakness, skin changes, and additional diagnostic modalities. The next st…
View article: Spatial transcriptomic analysis of muscle biopsy from patients with treatment-naive juvenile dermatomyositis reveals mitochondrial abnormalities despite disease-related interferon-driven signature
Spatial transcriptomic analysis of muscle biopsy from patients with treatment-naive juvenile dermatomyositis reveals mitochondrial abnormalities despite disease-related interferon-driven signature Open
This study highlights mitochondrial dysfunction as a consistent pathological feature in JDM muscle, which may be independent of interferon-driven inflammation. These findings highlight the potential for mitochondrial-targeted therapies in …
View article: Spatial transcriptomic analysis of muscle biopsy from treatment-naive juvenile dermatomyositis patients reveals mitochondrial abnormalities despite disease-related interferon driven signature
Spatial transcriptomic analysis of muscle biopsy from treatment-naive juvenile dermatomyositis patients reveals mitochondrial abnormalities despite disease-related interferon driven signature Open
Objectives This study aimed to investigate the spatial transcriptomic landscape of muscle tissue from treatment-naïve juvenile dermatomyositis (JDM) patients in comparison to healthy paediatric muscle tissue. Methods Muscle biopsies from t…
View article: ABS0014 SPATIAL TRANSCRIPTOMIC INSIGHTS INTO INTERFERON AND MITOCHONDRIAL PATHWAY DYSREGULATION IN JUVENILE DERMATOMYOSITIS MUSCLE BIOPSIES
ABS0014 SPATIAL TRANSCRIPTOMIC INSIGHTS INTO INTERFERON AND MITOCHONDRIAL PATHWAY DYSREGULATION IN JUVENILE DERMATOMYOSITIS MUSCLE BIOPSIES Open
View article: Anti-Sp4 and anti-CCAR1 autoantibodies in UK <i>vs</i> US patients with adult and juvenile-onset anti-TIF1γ-positive myositis
Anti-Sp4 and anti-CCAR1 autoantibodies in UK <i>vs</i> US patients with adult and juvenile-onset anti-TIF1γ-positive myositis Open
Objectives Anti-transcriptional intermediary factor 1γ (TIF1γ) autoantibodies are associated with malignancy in adult-onset idiopathic inflammatory myopathy (IIM) and this risk is attenuated if patients are also positive for anti-specifici…
View article: OA36 Systemic juvenile idiopathic arthritis: the Great Ormond Street Hospital experience (2005-2021)
OA36 Systemic juvenile idiopathic arthritis: the Great Ormond Street Hospital experience (2005-2021) Open
Background/Aims sJIA is a complex, systemic-inflammatory disorder. The proposed biphasic model of disease suggests that unchecked early auto-inflammation driven by increased innate immune activation, including dysregulation of IL-1 and IL-…
View article: TIF1-gamma IgG2 isotype is not associated with malignancy in juvenile dermatomyositis patients
TIF1-gamma IgG2 isotype is not associated with malignancy in juvenile dermatomyositis patients Open
International audience
View article: Mental health in paediatric and adult myositis-related diseases: current state of research, interventions, and future steps from the MIHRA Psychological Impact Scientific Working Group
Mental health in paediatric and adult myositis-related diseases: current state of research, interventions, and future steps from the MIHRA Psychological Impact Scientific Working Group Open
Psychological and emotional well-being are critical aspects of overall health for individuals with chronic rheumatologic conditions. Mental health-related literature, however, predominantly focuses on systemic lupus erythematosus or rheuma…
View article: Systemic juvenile idiopathic arthritis: The Great Ormond Street Hospital experience (2005–2021)
Systemic juvenile idiopathic arthritis: The Great Ormond Street Hospital experience (2005–2021) Open
Systemic juvenile idiopathic arthritis (sJIA) is a complex, systemic inflammatory disorder driven by both innate and adaptive immunity. Improved understanding of sJIA pathophysiology has led to recent therapeutic advances including a growi…
View article: Moving forward together: collaborative landscapes of research in idiopathic inflammatory myopathies and calcinosis
Moving forward together: collaborative landscapes of research in idiopathic inflammatory myopathies and calcinosis Open
This editorial refers to ‘Development of a computed tomography calcium scoring technique for assessing calcinosis distribution, pattern and burden in dermatomyositis’, by Briana A. Cervantes et al., 2024;63:58–63.
View article: Proposed Response Parameters for <scp>Twelve‐Month</scp> Drug Trial in Juvenile Systemic Sclerosis: Results of the Hamburg International Consensus Meetings
Proposed Response Parameters for <span>Twelve‐Month</span> Drug Trial in Juvenile Systemic Sclerosis: Results of the Hamburg International Consensus Meetings Open
Objective Juvenile systemic sclerosis (SSc) is an orphan disease, associated with high morbidity and mortality. New treatment strategies are much needed, but clearly defining appropriate outcomes is necessary if successful therapies are to…
View article: OA39 Development of a Childhood Lupus Low Disease Activity State definition: recommendations from the International Childhood Lupus Treat-to-Target Task Force
OA39 Development of a Childhood Lupus Low Disease Activity State definition: recommendations from the International Childhood Lupus Treat-to-Target Task Force Open
Background/Aims International interest in development of treat-to-target (T2T) in both childhood-onset systemic lupus erythematosus (cSLE) and adult-onset SLE (aSLE) is increasing. T2T could facilitate more effective and structured use of …
View article: PReS-endorsed international childhood lupus T2T task force definition of childhood lupus low disease activity state (cLLDAS)
PReS-endorsed international childhood lupus T2T task force definition of childhood lupus low disease activity state (cLLDAS) Open
View article: Towards development of treat to target (T2T) in childhood-onset systemic lupus erythematosus: PReS-endorsed overarching principles and points-to-consider from an international task force
Towards development of treat to target (T2T) in childhood-onset systemic lupus erythematosus: PReS-endorsed overarching principles and points-to-consider from an international task force Open
View article: Management and treatment of children, young people and adults with systemic lupus erythematosus: British Society for Rheumatology guideline scope
Management and treatment of children, young people and adults with systemic lupus erythematosus: British Society for Rheumatology guideline scope Open
The objective of this guideline is to provide up-to-date, evidence-based recommendations for the management of SLE that builds upon the existing treatment guideline for adults living with SLE published in 2017. This will incorporate advanc…
View article: OA05 Clinical presentation, risk factors and prognosis of MDA5-positive JDM; clinical diversity and red flags
OA05 Clinical presentation, risk factors and prognosis of MDA5-positive JDM; clinical diversity and red flags Open
Introduction/Background MDA5-positive juvenile dermatomyositis (JDM) represents a distinct clinical phenotype associated with skin and oral ulceration, milder muscle involvement and a higher incidence of interstitial lung disease (ILD) and…
View article: Panel sequencing links rare, likely damaging gene variants with distinct clinical phenotypes and outcomes in juvenile-onset SLE
Panel sequencing links rare, likely damaging gene variants with distinct clinical phenotypes and outcomes in juvenile-onset SLE Open
Objectives Juvenile-onset systemic lupus erythematosus (jSLE) affects 15–20% of lupus patients. Clinical heterogeneity between racial groups, age groups and individual patients suggests variable pathophysiology. This study aimed to identif…
View article: Real world treatment of juvenile-onset systemic lupus erythematosus: Data from the UK JSLE cohort study
Real world treatment of juvenile-onset systemic lupus erythematosus: Data from the UK JSLE cohort study Open
Most UK JSLE patients required ≥two immunomodulators, with MMF used most commonly.
View article: British Society for Rheumatology guideline on management of paediatric, adolescent and adult patients with idiopathic inflammatory myopathy
British Society for Rheumatology guideline on management of paediatric, adolescent and adult patients with idiopathic inflammatory myopathy Open
BackgroundIdiopathic inflammatory myopathy (IIM) is a multi-system autoimmune condition characterised by muscle inflammation (myositis), interstitial lung disease (ILD), and skin manifestations with an incidence of up to 19 per 1,000,000 p…
View article: Attainment of low disease activity and remission targets reduces the risk of severe flare and new damage in childhood lupus
Attainment of low disease activity and remission targets reduces the risk of severe flare and new damage in childhood lupus Open
Objectives To assess the achievability and effect of attaining low disease activity (LDA) or remission in childhood-onset SLE (cSLE). Methods Attainment of three adult-SLE derived definitions of LDA (LLDAS, LA, Toronto-LDA), and four defin…
View article: Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: Data from the UK Juvenile-onset systemic lupus erythematosus cohort study
Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: Data from the UK Juvenile-onset systemic lupus erythematosus cohort study Open
Introduction Juvenile-onset systemic lupus erythematosus (JSLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Neuropsychiatric (NP) involvement is a severe complication, encompassing a heterogeneous ra…
View article: 808 Prospective UK and Ireland population-based study of juvenile-onset systemic lupus erythematosus
808 Prospective UK and Ireland population-based study of juvenile-onset systemic lupus erythematosus Open
Background Juvenile-onset systemic lupus erythematosus (JSLE) is a rare, multi-system autoimmune disease. SLE most frequently affects adults but onset is in childhood in up to 20% of cases. Where onset is in childhood, disease can be more …
View article: Efficacy and safety of belimumab in paediatric and adult patients with systemic lupus erythematosus: an across-study comparison
Efficacy and safety of belimumab in paediatric and adult patients with systemic lupus erythematosus: an across-study comparison Open
Objective To assess the efficacy and safety of belimumab in paediatric versus adult patients with systemic lupus erythematosus (SLE). Methods We performed across-study comparisons of patients with active SLE who received belimumab or place…
View article: Limited sensitivity and specificity of the ACR/EULAR-2019 classification criteria for SLE in JSLE?—observations from the UK JSLE Cohort Study
Limited sensitivity and specificity of the ACR/EULAR-2019 classification criteria for SLE in JSLE?—observations from the UK JSLE Cohort Study Open
Objectives This study aimed to test the performance of the new ACR and EULAR criteria, that include ANA positivity as entry criterion, in JSLE. Methods Performance of the ACR/EULAR-2019 criteria were compared with Systemic Lupus Internatio…
View article: ‘It is good to have a target in mind’: qualitative views of patients and parents informing a treat to target clinical trial in juvenile-onset systemic lupus erythematosus
‘It is good to have a target in mind’: qualitative views of patients and parents informing a treat to target clinical trial in juvenile-onset systemic lupus erythematosus Open
Objective We sought to explore patient and parental views on treatment targets, outcome measures and study designs being considered for a future JSLE treat-to-target (T2T) study. Methods We conducted topic-guided, semistructured interviews…
View article: Clinical and laboratory phenotypes in juvenile-onset Systemic Lupus Erythematosus across ethnicities in the UK
Clinical and laboratory phenotypes in juvenile-onset Systemic Lupus Erythematosus across ethnicities in the UK Open
Systemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disease. Patients diagnosed with juvenile-onset SLE (jSLE), when compared to individuals with adult-onset SLE, develop more severe organ involvement, increased diseas…
View article: The Vasculopathy of Juvenile Dermatomyositis: Endothelial Injury, Hypercoagulability, and Increased Arterial Stiffness
The Vasculopathy of Juvenile Dermatomyositis: Endothelial Injury, Hypercoagulability, and Increased Arterial Stiffness Open
Objective Vasculopathy is considered central to the pathogenesis of juvenile dermatomyositis (DM) and is associated with severe extramuscular manifestations. We undertook this study to investigate the hypothesis that the vasculopathy of ju…
View article: Development and Testing of Reduced Versions of the Manual Muscle Test-8 in Juvenile Dermatomyositis
Development and Testing of Reduced Versions of the Manual Muscle Test-8 in Juvenile Dermatomyositis Open
Objective. To develop and test shortened versions of the Manual Muscle Test-8 (MMT-8) in juvenile dermatomyositis (JDM). Methods. Construction of reduced tools was based on a retrospective analysis of individual scores of MMT-8 muscle grou…
View article: A case of Myhre syndrome mimicking juvenile scleroderma
A case of Myhre syndrome mimicking juvenile scleroderma Open
Background Myhre syndrome is a genetic disorder caused by gain of function mutations in the SMAD Family Member 4 (SMAD4) gene, resulting in progressive, proliferative skin and organ fibrosis. Skin thickening and joint contractures are ofte…