Clark Jeffries
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View article: Plasma complement and coagulation proteins as prognostic factors of negative symptoms: An analysis of the NAPLS 2 and 3 studies
Plasma complement and coagulation proteins as prognostic factors of negative symptoms: An analysis of the NAPLS 2 and 3 studies Open
The results indicate that plasma complement and coagulation regulator levels are prognostic factors of negative symptoms, independent of clinical and demographic prognostic factors. These results suggest complement and coagulation regulato…
View article: Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms
Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms Open
We demonstrate that elevated HP is robustly observed in those at CHR for psychosis, irrespective of transition to psychosis. HP is longitudinally associated with poorer functioning and greater symptom severity. These results agree with pre…
View article: Linking enlarged choroid plexus with plasma analyte and structural phenotypes in clinical high risk for psychosis: A multisite neuroimaging study
Linking enlarged choroid plexus with plasma analyte and structural phenotypes in clinical high risk for psychosis: A multisite neuroimaging study Open
View article: Review of: "Decoding the Correlation Coefficient: A Window into Association, Fit, and Prediction in Linear Bivariate Relationships"
Review of: "Decoding the Correlation Coefficient: A Window into Association, Fit, and Prediction in Linear Bivariate Relationships" Open
Potential competing interests: No potential competing interests to
View article: Linking Enlarged Choroid Plexus with Plasma Analyte and Structural Phenotypes in Clinical High Risk for Psychosis: A Multisite Neuroimaging Study
Linking Enlarged Choroid Plexus with Plasma Analyte and Structural Phenotypes in Clinical High Risk for Psychosis: A Multisite Neuroimaging Study Open
Background Choroid plexus (ChP) enlargement exists in first-episode and chronic psychosis, but whether enlargement occurs before psychosis onset is unknown. This study investigated whether ChP volume is enlarged in individuals with clinica…
View article: Reproducibility and Visual Inspection of Data
Reproducibility and Visual Inspection of Data Open
View article: Pre-capture multiplexing provides additional power to detect copy number variation in exome sequencing
Pre-capture multiplexing provides additional power to detect copy number variation in exome sequencing Open
View article: Clinician Recognition of First Episode Psychosis
Clinician Recognition of First Episode Psychosis Open
Purpose: Psychotic disorders develop during mid-adolescence through early adulthood, with the initial few months a “critical period” offering the greatest promise for recovery. However, the duration of untreated psychosis is typically over…
View article: Polygenic risk score contribution to psychosis prediction in a target population of persons at clinical high risk
Polygenic risk score contribution to psychosis prediction in a target population of persons at clinical high risk Open
Objective: The 2-year risk of psychosis in persons who meet research criteria for a high-risk syndrome is about 15%225%; improvements in risk prediction accuracy would benefit the development and implementation of preventive interventions.…
View article: Potential Roles of Redox Dysregulation in the Development of Schizophrenia
Potential Roles of Redox Dysregulation in the Development of Schizophrenia Open
Converging evidence implicates redox dysregulation as a pathological mechanism driving the emergence of psychosis. Increased oxidative damage and decreased capacity of intracellular redox modulatory systems are consistent findings in perso…
View article: Polygenic Risk Score Contribution to Psychosis Prediction in a Target Population of Persons at Clinical High Risk
Polygenic Risk Score Contribution to Psychosis Prediction in a Target Population of Persons at Clinical High Risk Open
The PRS discriminates psychosis converters from nonconverters and modestly improves individualized psychosis risk prediction when added to a psychosis risk calculator. The schizophrenia PRS shows promise in enhancing risk prediction in per…
View article: Tobacco use and psychosis risk in persons at clinical high risk
Tobacco use and psychosis risk in persons at clinical high risk Open
Aim: To evaluate the role of tobacco use in the development of psychosis in individuals at clinical high risk. Method: The North American Prodrome Longitudinal Study is a 2-year multi-site prospective case control study of persons at clini…
View article: Networks of blood proteins in the neuroimmunology of schizophrenia
Networks of blood proteins in the neuroimmunology of schizophrenia Open
View article: Networks of blood proteins in the neuroimmunology of schizophrenia
Networks of blood proteins in the neuroimmunology of schizophrenia Open
Levels of certain circulating cytokines and related immune system molecules are consistently altered in schizophrenia and related disorders. In addition to absolute analyte levels, we sought analytes in correlation networks that could be p…
View article: 155. Tobacco Use and Psychosis Risk in Persons at Clinical High Risk
155. Tobacco Use and Psychosis Risk in Persons at Clinical High Risk Open
Background: The purpose of this study was to evaluate the role of tobacco use in the development of psychosis in individuals at clinical high risk. Methods: The North American Prodrome Longitudinal Study is a 2-year multisite prospective c…
View article: 59.4 Networks of Blood Analytes are Collectively Informative of Risk of Conversion to Schizophrenia
59.4 Networks of Blood Analytes are Collectively Informative of Risk of Conversion to Schizophrenia Open
\nBackground: The presence and severity of attenuated-psychosis symptoms define a clinical high risk (CHR) population at elevated risk for psychotic disorders. The NAPLS project is a prospective study of mechanisms contributing to psychosi…
View article: SU96. The Role of MicroRNA Expression in Cortical Development During Conversion to Psychosis
SU96. The Role of MicroRNA Expression in Cortical Development During Conversion to Psychosis Open
Background: In a recent report of the North American Prodrome Longitudinal Study (NAPLS), clinical high-risk individuals who converted to psychosis showed a steeper rate of cortical gray matter reduction compared with nonconverters and hea…
View article: The Role of microRNA Expression in Cortical Development During Conversion to Psychosis
The Role of microRNA Expression in Cortical Development During Conversion to Psychosis Open
View article: The Role of microRNA Expression in Cortical Development during Conversion to Psychosis
The Role of microRNA Expression in Cortical Development during Conversion to Psychosis Open
In a recent report of the North American Prodrome Longitudinal Study (NAPLS), clinical high-risk individuals who converted to psychosis showed a steeper rate of cortical gray matter reduction compared with non-converters and healthy contro…
View article: Insights into psychosis risk from leukocyte microRNA expression
Insights into psychosis risk from leukocyte microRNA expression Open
View article: An Individualized Risk Calculator for Research in Prodromal Psychosis
An Individualized Risk Calculator for Research in Prodromal Psychosis Open
A risk calculator comparable in accuracy to those for cardiovascular disease and cancer is available to predict individualized conversion risks in newly ascertained clinical high-risk cases. Given that the risk calculator can be validly ap…
View article: Reproducibility and Visual Inspection of Data
Reproducibility and Visual Inspection of Data Open
In 2011, Moreau et al. reported in Biological Psychiatry findings concerning patterns of microRNA (miRNA) expression in postmortem samples from prefrontal cortex (Brodmann area 9) from the Stanley Medical Research Institute (SMRI) (Chevy C…
View article: Severity of thought disorder predicts psychosis in persons at clinical high-risk
Severity of thought disorder predicts psychosis in persons at clinical high-risk Open
View article: Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk
Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk Open
Individuals at clinical high-risk (CHR) who progress to fully psychotic symptoms have been observed to show a steeper rate of cortical gray matter reduction compared with those without symptomatic progression and with healthy controls. Whe…