Claudine Berr
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View article: Selected social and lifestyle correlates of brain health markers: the Cross‐Cohort Collaboration Consortium
Selected social and lifestyle correlates of brain health markers: the Cross‐Cohort Collaboration Consortium Open
INTRODUCTION To investigate the associations of education level, marital status, and physical activity with dementia risk and brain MRI markers. METHODS Data from six community‐based samples from the Cross‐Cohort Collaboration Consortium w…
View article: Associations of the LIBRA risk score with cognitive resistance to susceptibility genes for dementia
Associations of the LIBRA risk score with cognitive resistance to susceptibility genes for dementia Open
Background Some older adults succeed in maintaining excellent cognition despite high genetic risk for Alzheimer’s disease (AD), reflecting cognitive resistance (CR) to potential neuropathologies. Although the etiological factors for CR are…
View article: Extremely rare CNVs contributing to Alzheimer disease risk: a case-control association analysis of exome sequencing data from 22,319 individuals
Extremely rare CNVs contributing to Alzheimer disease risk: a case-control association analysis of exome sequencing data from 22,319 individuals Open
Rare coding single nucleotide variants (SNV) and short insertions or deletions (indels) contribute to Alzheimer disease (AD) genetic risk, from pathogenic variants in autosomal dominant genes to risk factors with diverse effects. In contra…
View article: Hearing Loss, Hearing Aids, and Cognition
Hearing Loss, Hearing Aids, and Cognition Open
Importance Most observational studies examining the association between hearing loss (HL) and cognitive impairment used subjective measures of hearing and addressed only one dimension of cognition, and very few investigated the potential b…
View article: Exposure to airborne cadmium and lead and cognitive performance among Lyon residents within the French CONSTANCES cohort
Exposure to airborne cadmium and lead and cognitive performance among Lyon residents within the French CONSTANCES cohort Open
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View article: Association of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline
Association of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline Open
INTRODUCTION Evaluating whether genetic susceptibility modifies the impact of lifestyle‐related factors on dementia is critical for prevention. METHODS We studied 5170 participants from a French cohort of older persons free of dementia at …
View article: Mapping Cognitive Trajectories and Detecting Early Dementia Using the Mini-Mental State Examination Cognitive Charts: Application to the French Three-City Cohort
Mapping Cognitive Trajectories and Detecting Early Dementia Using the Mini-Mental State Examination Cognitive Charts: Application to the French Three-City Cohort Open
The Cognitive Quotient (QuoCo) classification algorithm monitoring decline on age- and education-adjusted Mini-Mental State Examination (MMSE)-derived cognitive charts has proved superior to the conventionally-used cut-off for identifying …
View article: Lifestyle for Brain Health Score, Genetic Risk and Incidence of Dementia
Lifestyle for Brain Health Score, Genetic Risk and Incidence of Dementia Open
Background Assessing whether modifiable factors are associated with dementia risk regardless of genetic risk for the disease is primordial for precision prevention. So far, studies on gene‐by‐environment interactions (GxE) in dementia have…
View article: The role of cardiovascular health and vascular events in the relationship between excessive daytime sleepiness and dementia risk
The role of cardiovascular health and vascular events in the relationship between excessive daytime sleepiness and dementia risk Open
Summary Many studies suggest a relationship between excessive daytime sleepiness (EDS) and dementia incidence, but the underlying mechanisms remain uncertain. The study aimed to investigate the role of cardiovascular burden in the relation…
View article: Ambient Air Pollution Exposure and Cerebral White Matter Hyperintensities in Older Adults: A Cross-Sectional Analysis in the Three-City Montpellier Study
Ambient Air Pollution Exposure and Cerebral White Matter Hyperintensities in Older Adults: A Cross-Sectional Analysis in the Three-City Montpellier Study Open
In this population-based study in older adults, exposure was associated with increased risk of high WMH volume in the temporal lobe, strengthening the evidence on adverse effect on the brain. Further studies looking at different markers …
View article: Domain mapping of disease mutations supports genetic testing of specific<i>SORL1</i>variants in familial Alzheimer’s Disease
Domain mapping of disease mutations supports genetic testing of specific<i>SORL1</i>variants in familial Alzheimer’s Disease Open
Background Protein truncating variants (PTVs) in SORL1 are observed almost exclusively in Alzheimer’s Disease (AD) cases, but the effect of rare SORL1 missense variants is unclear. Methods To identify high-priority missense variants (HPVs)…
View article: Comparison of ultrasensitive and mass spectrometry quantification of blood-based amyloid biomarkers for Alzheimer’s disease diagnosis in a memory clinic cohort
Comparison of ultrasensitive and mass spectrometry quantification of blood-based amyloid biomarkers for Alzheimer’s disease diagnosis in a memory clinic cohort Open
Background Alzheimer’s disease (AD) is a complex neurodegenerative disorder with β-amyloid pathology as a key underlying process. The relevance of cerebrospinal fluid (CSF) and brain imaging biomarkers is validated in clinical practice for…
View article: How Is Brain Aging Influenced by Where We Live?
How Is Brain Aging Influenced by Where We Live? Open
When our brains are healthy, we can memorize, pay attention, reason, move, communicate, make decisions, and complete complex tasks. As some people get older, they can no longer do those things—they suffer from cognitive disorders that coul…
View article: Association between ambient air pollution exposure and plasma β-amyloid levels in the French Three-City study : preliminary results
Association between ambient air pollution exposure and plasma β-amyloid levels in the French Three-City study : preliminary results Open
Background: Existing research suggests an association between air pollution exposure and Alzheimer's Disease (AD). However, underlying biological mechanisms are still unknown. We aimed to evaluate if air pollution exposure was associated w…
View article: Association between greenspace exposure and different domains of cognitive function in the French CONSTANCES cohort
Association between greenspace exposure and different domains of cognitive function in the French CONSTANCES cohort Open
BACKGROUND AND AIM Greenspace has been suggested to be associated with better cognitive function in adults. We assessed the association between residential surrounding greenspace and different domains of cognition in the French CONSTANCES …
View article: Pathways associated with air pollution exposure and cognitive outcomes: a systematic review of the epidemiological studies
Pathways associated with air pollution exposure and cognitive outcomes: a systematic review of the epidemiological studies Open
BACKGROUND AND AIM Air pollution is a modifiable risk factor for dementia, however the pathways through which air pollution affects cognition in the elderly are not well-understood. We reviewed the epidemiological evidence on the factors m…
View article: Greenspace exposure and depressive symptoms: findings from the French CONSTANCES cohort
Greenspace exposure and depressive symptoms: findings from the French CONSTANCES cohort Open
Background and Aim: The association between greenspace exposure and different dimensions of depression is yet to be established. We aimed to explore this association in a large population-based cohort. Methods: Data from the enrollment pha…
View article: Association between long-term ambient air pollution exposure and handgrip strength change in the French CONSTANCES cohort
Association between long-term ambient air pollution exposure and handgrip strength change in the French CONSTANCES cohort Open
Background and aim Literature is scarce regarding the effect of exposure to outdoor air pollution on frailty. In this longitudinal study, we aimed to assess the association between long-term air pollution exposure and handgrip muscle stren…
View article: Association of long-term exposure to ambient air pollution with retinal neurodegeneration on optical coherence tomography: the prospective Alienor study
Association of long-term exposure to ambient air pollution with retinal neurodegeneration on optical coherence tomography: the prospective Alienor study Open
Background and aim Chronic exposure to air pollution may have adverse effects on the central nervous system (CNS). The retinal nerve fiber layer (RNFL) is a part of the CNS. RNFL thinning is a hallmark of glaucoma, the second leading cause…
View article: Summary statistics for "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's Disease"
Summary statistics for "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's Disease" Open
These are the burden test results (summary statistics) for the publication: "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s Disease", Nature Genetics, 2022. Format: tab-separated-valu…
View article: Summary statistics for "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's Disease"
Summary statistics for "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's Disease" Open
These are the burden test results (summary statistics) for the publication: "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s Disease", Nature Genetics, 2022. Format: tab-separated-valu…
View article: Modeling exposure to airborne metals using moss biomonitoring in cemeteries in two urban areas around Paris and Lyon in France
Modeling exposure to airborne metals using moss biomonitoring in cemeteries in two urban areas around Paris and Lyon in France Open
Exposure of the general population to airborne metals remains poorly estimated despite the potential health risks. Passive moss biomonitoring can proxy air quality at fine resolution over large areas, mainly in rural areas. We adapted the …