Claude Bouchard
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View article: Variation in cycling exercise mechanical efficiency in the <scp>HERITAGE</scp> Family Study
Variation in cycling exercise mechanical efficiency in the <span>HERITAGE</span> Family Study Open
The objectives of the study were to assess the effects of cycling endurance exercise training and sex on cycling exercise mechanical efficiency (ME) and to explore its associations with body composition, glycemic profile, and skeletal musc…
View article: Analysis of spatiotemporal patterns of TB transmission in a prison outbreak
Analysis of spatiotemporal patterns of TB transmission in a prison outbreak Open
Background In May 2024, a highly infectious pulmonary tuberculosis (TB) case (smear 3+, cavitary disease) was identified after a 7-week symptomatic period in a century-old Montréal prison wing with natural ventilation, housing ∼200 incarce…
View article: Plasma Proteomics of Exercise Blood Pressure and Incident Hypertension
Plasma Proteomics of Exercise Blood Pressure and Incident Hypertension Open
Importance Blood pressure response during acute exercise (exercise blood pressure [EBP]) is associated with the future risk of hypertension and cardiovascular disease (CVD). Biochemical characterization of EBP could inform disease biology …
View article: Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose
Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose Open
Smoking is a potentially causal behavioral risk factor for type 2 diabetes (T2D), but not all smokers develop T2D. It is unknown whether genetic factors partially explain this variation. We performed genome-environment-wide interaction stu…
View article: Omics-driven investigation of the biology underlying intrinsic submaximal working capacity and its trainability
Omics-driven investigation of the biology underlying intrinsic submaximal working capacity and its trainability Open
Multi-omics and in silico explorations of the genes and underlying biology of submaximal exercise capacity and its response to 20 wk of endurance training were undertaken. Prioritized genes were identified: 13 genes for variation in submax…
View article: Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma
Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma Open
Although many novel gene-metabolite and gene-protein associations have been identified using high-throughput biochemical profiling, systematic studies that leverage human genetics to illuminate causal relationships between circulating prot…
View article: In memoriam: <scp>Roy J. Shephard</scp>, <scp>MD</scp>, <scp>PhD</scp>, <scp>DPE</scp> (1929–2023)
In memoriam: <span>Roy J. Shephard</span>, <span>MD</span>, <span>PhD</span>, <span>DPE</span> (1929–2023) Open
The authors declare no conflict of interest. Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
View article: Plasma Proteomic Kinetics in Response to Acute Exercise
Plasma Proteomic Kinetics in Response to Acute Exercise Open
Regular exercise has many favorable effects on human health, which may be mediated in part by the release of circulating bioactive factors during each bout of exercise. Limited data exist regarding the kinetic responses of plasma proteins …
View article: Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation
Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation Open
Aims Apolipoprotein C-II (ApoC-II) is thought to activate lipoprotein lipase (LPL) and is therefore a possible target for treating hypertriglyceridemia. Its relationship with cardiovascular risk has not been investigated in large-scale epi…
View article: Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations
Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations Open
Regular exercise leads to widespread salutary effects, and there is increasing recognition that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited data exist regarding the plasma proteomic changes th…
View article: Plasma proteomic risk markers of incident type 2 diabetes reflect physiologically distinct components of glucose-insulin homeostasis
Plasma proteomic risk markers of incident type 2 diabetes reflect physiologically distinct components of glucose-insulin homeostasis Open
High-throughput proteomics allow researchers to simultaneously explore the roles of thousands of biomarkers in the pathophysiology of diabetes. We conducted proteomic association studies of incident type 2 diabetes and physiologic response…
View article: Plasma proteomic risk markers of incident type 2 diabetes reflect physiologically distinct components of glucose-insulin homeostasis
Plasma proteomic risk markers of incident type 2 diabetes reflect physiologically distinct components of glucose-insulin homeostasis Open
High-throughput proteomics allow researchers to simultaneously explore the roles of thousands of biomarkers in the pathophysiology of diabetes. We conducted proteomic association studies of incident type 2 diabetes and physiologic response…
View article: Plasma Proteomic Risk Markers of Incident Type 2 Diabetes Reflect Physiologically Distinct Components of Glucose-Insulin Homeostasis
Plasma Proteomic Risk Markers of Incident Type 2 Diabetes Reflect Physiologically Distinct Components of Glucose-Insulin Homeostasis Open
High-throughput proteomics allows researchers to simultaneously explore the roles of thousands of biomarkers in the pathophysiology of diabetes. We conducted proteomic association studies of incident type 2 diabetes and physiologic respons…
View article: Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods
Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods Open
High-throughput proteomic profiling using antibody or aptamer-based affinity reagents is used increasingly in human studies. However, direct analyses to address the relative strengths and weaknesses of these platforms are lacking. We asses…
View article: Effect of individual characteristics and aerobic training on the %HRR‐%<i>V</i>O<sub>2</sub>R relationship
Effect of individual characteristics and aerobic training on the %HRR‐%<i>V</i>O<sub>2</sub>R relationship Open
This study aimed to assess if, during incremental exercise, considering individual characteristics can make the relationship between the percentages of heart rate (HRR) and oxygen uptake ( V̇ O 2 R) reserve either 1:1 or more accurate. Cycl…
View article: The HERITAGE Family Study: A Review of the Effects of Exercise Training on Cardiometabolic Health, with Insights into Molecular Transducers
The HERITAGE Family Study: A Review of the Effects of Exercise Training on Cardiometabolic Health, with Insights into Molecular Transducers Open
The aim of the HERITAGE Family Study was to investigate individual differences in response to a standardized endurance exercise program, the role of familial aggregation, and the genetics of response levels of cardiorespiratory fitness and…
View article: Genetic control of body weight by the human brain proteome
Genetic control of body weight by the human brain proteome Open
Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with body weight but the biological relevance of most remains unexplored. Given the critical role of the brain in multiple biological processes …
View article: Physical activity and sedentary behavior; mechanistic insights and role in disease prevention
Physical activity and sedentary behavior; mechanistic insights and role in disease prevention Open
Even though physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Here, we combine data for up to 674,980 individuals from 51 studies in a trans-ancestry meta-a…
View article: Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training
Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training Open
Despite good adherence to supervised endurance exercise training (EET), some individuals experience no or little improvement in peripheral insulin sensitivity. The genetic and molecular mechanisms underlying this phenomenon are currently n…