Jean‐Claude Daubert
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View article: Rates and predictors of cardiovascular and non‐cardiovascular outcomes in heart failure with preserved ejection fraction
Rates and predictors of cardiovascular and non‐cardiovascular outcomes in heart failure with preserved ejection fraction Open
Aims The detailed sub‐categories of death and hospitalization, and the impact of comorbidities on cause‐specific outcomes, remain poorly understood in heart failure (HF) with preserved ejection fraction (HFpEF). We sought to evaluate rates…
Ablation of multifocal premature ventricular contractions using automated pace-mapping software Open
Quantitative morphology-matching software can be used to obtain a detailed map identifying the site of origin of each single PVC, and successful ablation can be performed at these sites, even if activation points cannot be obtained due to …
View article: The effect of cardiac resynchronization without a defibrillator on morbidity and mortality: an <scp>individual patient data meta‐analysis</scp> of <scp>COMPANION</scp> and <scp>CARE‐HF</scp>
The effect of cardiac resynchronization without a defibrillator on morbidity and mortality: an <span>individual patient data meta‐analysis</span> of <span>COMPANION</span> and <span>CARE‐HF</span> Open
Aims Cardiac resynchronization therapy (CRT) reduces morbidity and mortality for patients with heart failure, reduced left ventricular ejection fraction, QRS duration >130 ms and in sinus rhythm. The aim of this study was to identify patie…
View article: Eligibility of patients with heart failure with preserved ejection fraction for sacubitril/valsartan according to the PARAGON‐HF trial
Eligibility of patients with heart failure with preserved ejection fraction for sacubitril/valsartan according to the PARAGON‐HF trial Open
Aims In the heart failure (HF) with preserved ejection fraction (HFpEF) PARAGON‐HF trial, sacubitril/valsartan vs. valsartan improved mortality/morbidity in patients with left ventricular ejection fraction (LVEF) below median (57%). We ass…
2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy Open
Pacing is an important part of electrophysiology and of cardiology in general. Whereas some of the situations requiring pacing are clear and have not changed over the years, many others have evolved and have been the subject of extensive r…
Predictors of long‐term outcome in heart failure with preserved ejection fraction: a follow‐up from the <span>KaRen</span> study Open
Aims Heart failure (HF) with preserved ejection fraction (HFpEF) has poor long‐term prognosis. We assessed rates and predictors of outcome 10 years after an acute episode of HF. Methods and results The Karolinska‐Rennes (KaRen) study enrol…
Redefining the Classifications of Response to Cardiac Resynchronization Therapy Open
For both CCS and reverse remodeling, patients who worsen with CRT have a high mortality, although remodeling was the more important endpoint. Patients who stabilize early with CRT have a much better prognosis than previously recognized, su…
Myeloperoxidase and related biomarkers are suggestive footprints of endothelial microvascular inflammation in HFpEF patients Open
Aims In heart failure (HF) with preserved ejection fraction (HFpEF), microvascular inflammation is proposed as an underlying mechanism. Myeloperoxidase (MPO) is associated with vascular dysfunction and prognosis in congestive HF. Methods a…
View article: Identification of novel pheno-groups in heart failure with preserved ejection fraction using machine learning
Identification of novel pheno-groups in heart failure with preserved ejection fraction using machine learning Open
Objective Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. We aimed to derive HFpEF phenotype-based groups ('phenogroups') based on clinical and echocardiogram data using machine learning, and to compare …
View article: ST2 in heart failure with preserved and reduced ejection fraction
ST2 in heart failure with preserved and reduced ejection fraction Open
In patients with HFpEF compared to HFrEF, crude levels of sST2 were lower but potentially more strongly associated with outcomes. The lower levels of sST2 in HFpEF than in HFrEF may reflect lower degrees of fibrosis, but the potentially st…
Procedural safety and long‐term follow‐up after pacemaker implantation in nonagenarians Open
Background The rate of pacemaker (PM) implantations is constantly growing. Since life expectancy of the population is projected to increase, a large number of nonagenarian patients will need PM implantation. We aimed at analyzing short‐ an…
Left atrial rather than left ventricular impaired mechanics are associated with the pro‐fibrotic <span>ST</span>2 marker and outcomes in heart failure with preserved ejection fraction Open
Aims Left ventricular ( LV ) mechanics have been extensively investigated in heart failure with preserved ejection fraction ( HF p EF ) overshadowing for a long time the potential role of left atrium ( LA ) in that setting. Soluble suppres…
The interaction of sex, height, and QRS duration on the effects of cardiac resynchronization therapy on morbidity and mortality: an individual‐patient data meta‐analysis Open
Aims To explore possible associations that may explain the greater benefit from cardiac resynchronization therapy (CRT) reported amongst women. Methods and results In an individual‐patient data meta‐analysis of five randomized controlled t…
Precision Medicine for Cardiac Resynchronization Open
Background: Clinical trials have established the average benefit of cardiac resynchronization therapy (CRT), but estimating benefit for individual patients remains difficult because of the heterogeneity in treatment response. Accordingly, …
P811Right versus left durable pulmonary vein isolation using the first and second generation cryoballoons: comparative results from a French multicenter study Open
Background: Pulmonary veins isolation (PVI) using the second-generation cryoballoon (CB2) is associated with improved outcomes compared to first generation (CB1).Little is known about the mechanisms underlying such improvement and whether …
The second generation cryoballoon has improved durable isolation of left but not right pulmonary veins: new insights from a multicentre study Open
Fewer reconnection gaps are observed during redo ablations of paroxysmal AF in patients primarily ablated with CB2. This difference is driven by less reconnection gaps observed in both left PVs, while no difference was observed for right P…
Pilot study using 3D–longitudinal strain computation in a multi-parametric approach for best selecting responders to cardiac resynchronization therapy Open
This new automatic software for analyzing 3D longitudinal strain curves is avoiding previous limitations of imaging techniques for assessing dyssynchrony and then its value will have to be tested in a large group of patients.
Peritoneal migration of an epicardial pacemaker Open
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Predictors of short‐term clinical response to cardiac resynchronization therapy Open
Aims Cardiac resynchronization therapy ( CRT ) reduces morbidity and mortality in patients with symptomatic heart failure and QRS prolongation but there is uncertainty about which patient characteristics predict short‐term clinical respons…
Inflammatory Biomarkers Predict Heart Failure Severity and Prognosis in Patients With Heart Failure With Preserved Ejection Fraction Open
Background— Underlying mechanisms in heart failure (HF) with preserved ejection fraction remain unknown. We investigated cardiovascular plasma biomarkers in HF with preserved ejection fraction and their correlation to diastolic dysfunction…