Claude Prigent
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Centriole Duplication at the Crossroads of Cell Cycle Control and Oncogenesis Open
Centriole duplication is a vital process for cellular organisation and function, underpinning essential activities such as cell division, microtubule organisation and ciliogenesis. This review summarises the latest research on the mechanis…
Cell Cycle Regulation of Centrosome Duplication Open
Centriole duplication is a critical process for cellular organisation and function, underpinning essential activities such as cell division, microtubule organisation and ciliogenesis. This comprehensive review synthesises current knowledge…
View article: Proteomic study identifies Aurora-A–mediated regulation of alternative splicing through multiple splicing factors
Proteomic study identifies Aurora-A–mediated regulation of alternative splicing through multiple splicing factors Open
The cell cycle regulator Aurora-A kinase presents an attractive target for cancer therapies, though its inhibition is also associated with toxic side effects. To gain a more nuanced understanding of Aurora-A function, we applied shotgun pr…
Aurora A Kinase Begins to Localize to the Centrosome in the S-phase of the Cell Cycle in the XL2 Cell Line Open
Background: The centrosome is one of the principal cell hubs, where numerous proteins important for intracellular regulatory processes are concentrated. One of them, serine-threonine kinase 6, alias Aurora A, is involved in centrosome dupl…
Duplication and Segregation of Centrosomes during Cell Division Open
During its division the cell must ensure the equal distribution of its genetic material in the two newly created cells, but it must also distribute organelles such as the Golgi apparatus, the mitochondria and the centrosome. DNA, the carri…
A Journey through Time on the Discovery of Cell Cycle Regulation Open
All living organisms on Earth are made up of cells, which are the functional unit of life. Eukaryotic organisms can consist of a single cell (unicellular) or a group of either identical or different cells (multicellular). Biologists have a…
An EMT–primary cilium–GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis Open
EMT induces cilium assembly and signaling to promote mammogenesis and tumorigenesis.
Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2 Open
Epithelial and haematologic tumours often show the overexpression of the serine/threonine kinase AURKA. Recently, AURKA was shown to localise at mitochondria, where it regulates mitochondrial dynamics and ATP production. Here we define the…
Mitotic timing is differentially controlled by A- and B-type cyclins and by CDC6 associated with a <i>bona fide</i> CDK inhibitor Xic1 in <i>Xenopus laevis</i> cell-free extract Open
The timing of the M-phase is precisely controlled by a CDC6-dependent mechanism inhibiting the mitotic histone H1 kinase. Here, we describe the differential regulation of the dynamics of this mitotic kinase activity by exogenous cyclin A o…
An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis Open
The Epithelial–Mesenchymal Transition (EMT) and primary ciliogenesis induce stem cell properties in basal Mammary Stem Cells (MaSCs) to promote mammogenesis, but the underlying mechanisms remain incompletely understood. Here, we show that …
Aurora-A phosphorylates splicing factors and regulates alternative splicing Open
Aurora-A kinase is well known to regulate progression through mitosis. However, the kinase also performs additional functions that could explain the failure of its inhibitors to be effective in cancer treatments. To identify these function…
CDC6 regulates mitotic CDK1 via cyclin B and not cyclin A and acts through a<i>bona fide</i>CDK inhibitor Xic1 Open
The timing of the M-phase entry and its progression are precisely controlled by a CDC6-dependent mechanism that inhibits the major mitotic kinase CDK1, and, thus, regulates the dynamic of CDK1 during the M-phase. In this paper, we describe…
Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2 Open
Epithelial and haematologic tumours often show the overexpression of the serine/threonine kinase AURKA. Recently, AURKA was shown to localise at mitochondria, where it regulates mitochondrial dynamics and ATP production. Here we define the…
Microtubule nucleation during central spindle assembly requires NEDD1 phosphorylation on serine 405 by Aurora A Open
During mitosis, the cell sequentially constructs two microtubule-based spindles to ensure faithful segregation of chromosomes. A bipolar spindle first pulls apart the sister chromatids, then a central spindle further separates them away. A…
Aurora kinase A localises to mitochondria to control organelle dynamics and energy production Open
Many epithelial cancers show cell cycle dysfunction tightly correlated with the overexpression of the serine/threonine kinase Aurora A (AURKA). Its role in mitotic progression has been extensively characterised, and evidence for new AURKA …
Author response: Aurora kinase A localises to mitochondria to control organelle dynamics and energy production Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Many epithelial cancers show …
Publisher's Note: Progesterone regulates the accumulation and the activation of Eg2 kinase in <i>Xenopus</i> oocytes (<i>J. Cell Sci.</i> 113, 1127-1138) Open
Journal of Cell Science was made aware of several issues raised by readers concerning duplication of data in Fig. 6A, Fig. 10B, Fig. 7A and Fig. 8A,B in J. Cell Sci. (2000) 113, 1127-1138.After discussion with the corresponding author, Cat…
Aurora A and cancer Open
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Aurora A kinase activity is required to maintain an active spindle assembly checkpoint during prometaphase Open
During the prometaphase stage of mitosis, the cell builds a bipolar spindle of microtubules that mechanically segregates sister chromatids between two daughter cells in anaphase. The spindle assembly checkpoint (SAC) is a quality control m…
Tight junctions negatively regulate mechanical forces applied to adherens junctions in vertebrate epithelial tissue Open
Epithelia are layers of polarised cells tightly bound to each other by adhesive contacts. Epithelia act as barriers between an organism and its external environment. Understanding how epithelia maintain their essential integrity while rema…
Regulation of Aurora Kinases and Their Activity Open
The three mitotic protein kinases Aurora-A, B and C are complementary enzymes that regulate multiple mitotic events. To do so, the different kinases must be locally activated, and the control of their activity is tightly regulated in time …
Aurora A activation in mitosis promoted by BuGZ Open
Protein phase separation or coacervation has emerged as a potential mechanism to regulate biological functions. We have shown that coacervation of a mostly unstructured protein, BuGZ, promotes assembly of spindle and its matrix. BuGZ in th…