Claude Solleux
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View article: Pharmacokinetic Prediction and Cytotoxicity of New Quercetin Derivatives
Pharmacokinetic Prediction and Cytotoxicity of New Quercetin Derivatives Open
Quercetin (QUE) possesses various pharmacological properties; however, its low bioavailability and solubility hinder its beneficial effects. Enzymatic glycosylation has been explored to improve these aspects. In the present study, we used …
View article: Sucrose phosphorylase from<i>Alteromonas mediterranea</i>: structural insight into the regioselective α-glucosylation of (+)-catechin
Sucrose phosphorylase from<i>Alteromonas mediterranea</i>: structural insight into the regioselective α-glucosylation of (+)-catechin Open
Sucrose phosphorylases, through transglycosylation reactions, are interesting enzymes that can transfer regioselectively glucose from sucrose, the donor substrate, onto acceptors like flavonoids to form glycoconjugates and hence modulate t…
View article: A Single Point Mutation Converts GH84 <i>O</i>-GlcNAc Hydrolases into Phosphorylases: Experimental and Theoretical Evidence
A Single Point Mutation Converts GH84 <i>O</i>-GlcNAc Hydrolases into Phosphorylases: Experimental and Theoretical Evidence Open
Glycoside hydrolases and phosphorylases are two major classes of enzymes responsible for the cleavage of glycosidic bonds. Here we show that two GH84 O-GlcNAcase enzymes can be converted to efficient phosphorylases by a single point mutati…