Claudia Acevedo-Morantes
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View article: Design of zwitterionic fluorescent polymers for membrane protein solubilization into native nanodiscs
Design of zwitterionic fluorescent polymers for membrane protein solubilization into native nanodiscs Open
Copolymers formed by non-alternating distributions of styrene and maleic acid monomers directly solubilize intact membranes into ∼10 nm discs. However, these copolymers are inherently polydisperse in terms of polymer structure, difficult t…
View article: Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition
Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition Open
Background In humans, two ubiquitously expressed N-myristoyltransferases, NMT1 and NMT2, catalyze myristate transfer to proteins to facilitate membrane targeting and signaling. We investigated the expression of NMT s in numerous cancers an…
View article: The effect of hydrophobic alkyl sidechains on size and solution behaviors of nanodiscs formed by alternating styrene maleamic copolymer
The effect of hydrophobic alkyl sidechains on size and solution behaviors of nanodiscs formed by alternating styrene maleamic copolymer Open
The development of amphipathic polymers, including various formulations of styrene-maleic acid (SMA) copolymers, has allowed the purification of increasing sizes and complexities of biological membrane protein assemblies in native nanodisc…
View article: Isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease
Isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease Open
Prions are transmissible agents causing lethal neurodegenerative diseases that are composed of aggregates of misfolded cellular prion protein (PrPSc). Despite non-fibrillar oligomers having been proposed as the most infectious prion partic…
View article: Homogeneous nanodiscs of native membranes formed by stilbene–maleic-acid copolymers
Homogeneous nanodiscs of native membranes formed by stilbene–maleic-acid copolymers Open
Methylstilbene-alt-maleic acid copolymers spontaneously convert biological membranes into bilayer discs with ∼20 nm diameters.
View article: A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles
A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles Open
To explore pathogenesis in a young Gerstmann-Sträussler-Scheinker Disease (GSS) patient, the corresponding mutation, an eight-residue duplication in the hydrophobic region (HR), was inserted into the wild type mouse PrP gene. Transgenic (T…
View article: Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice
Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice Open
Misfolding of proteins in the biosynthetic pathway in neurons may cause disturbed protein homeostasis and neurodegeneration. The prion protein (PrP C ) is a GPI-anchored protein that resides at the plasma membrane and may be misfolded to P…