Explanipedia

Incidência da Diabetes Mellitus Gestacional no Município de Araripe-CE de 2018 a 2025: um Estudo Epidemiológico Retrospectivo Open

Graça Costa, Natália Arruda, Yana Batista Brandão, Dinaldo Cavalcanti de Oliveira, E.F. Melo , et al. · 2025

A Diabetes Mellitus Gestacional (DMG) é caracterizada como uma forma de hiperglicemia diagnosticada pela primeira vez durante a gestação, independentemente da presença de sintomas ou da necessidade de tratamento medicamentoso. Nas últimas …

rhPTH(1-84) for hypoparathyroidism: a randomized study of patient-reported outcomes Open

Maria Luisa Brandi, Tamara Vokes, Natasha M. Appelman‐Dijkstra, Olulade Ayodele, Brigitte Decallonne , et al. · 2025

Objective To assess the impact of recombinant human parathyroid hormone (1-84) [rhPTH(1-84)] compared with placebo, in combination with conventional therapy with vitamin D and/or calcium supplements, on health-related quality of life (HRQo…

Relato de caso: Encefalomielite Disseminada Aguda (ADEM) causada pelo vírus Chikungunya em paciente idoso Open

André Morais Moura, Elielson Felix Gonçalves, Mariana Quirino Cavalcanti, Bruna Gisi, Karoline Nicolli Magalhães Pereira Costa , et al. · 2025

Introdução: A febre do Chikungunya é causada por um togavírus e é transmitida aos seres humanos pelo mosquito Aedes. As complicações neurológicas do Chikungunya geralmente ocorrem no vigésimo dia após o início dos sintomas. Dentre essas co…

Comparative analysis of follicular cell- derived thyroid carcinoma: assessing the impact of high-grade features in an advanced disease cohort Open

Margarida Brito Caldeira, Şule Canberk, Sofia Macedo, Miguel Melo, Valdemar Máximo , et al. · 2025

The 5th edition of the WHO Classification of Tumors of Endocrine Organs introduced the term Differentiated High-Grade Thyroid Carcinoma (DHGTC) to identify cases of differentiated follicular cell-derived thyroid carcinomas (DFCDTC) with a …

Trends in antidiabetic drug use in Portugal: 8 years real‐world data from a nationwide retrospective observational study (2017–2024) ( <span>TREND</span> ‐8 study) Open

João Sérgio Neves, Ana Rita Leite, Mafalda Marcelino, Miguel Melo, Paula Freitas , et al. · 2025

O Ensino de Filosofia, a sociedade de controle e a criação em Deleuze: o problema da filosofia no contexto da escola neoliberal Open

Miguel Melo, José Renato de Araújo Sousa · 2025

Genomic profiling of lymph node and distant metastases from papillary and poorly differentiated thyroid carcinomas Open

Valdemar Máximo, Miguel Melo, Manuel Sobrinho‐Simões, Paula Soares, Arnaud Da Cruz Paula · 2024

Genomic profiling of lymph node and distant metastases from papillary and poorly differentiated thyroid carcinomas Open

Valdemar Máximo, Miguel Melo, Manuel Sobrinho‐Simões, Paula Soares, Arnaud Da Cruz Paula · 2024

Purpose: To perform a molecular profiling of the metastases from papillary thyroid carcinomas (PTCs) and poorly differentiated thyroid carcinomas (PDTCs). Methods: We retrieved and analyzed the molecular and clinical features of 136 metast…

Pharmacological and therapeutic treatment of total pain in patients with metastatic breast cancer: narrative review on the importance of interdisciplinary intervention Open

Miguel Melo, Maria Eduarda Araújo, Carlos Oliveira · 2024

BACKGROUND AND OBJECTIVES: Considering the great impact suffered by women with metastatic breast cancer, manifested in physical and/or psychological symptoms, this study seeks to understand the impact of total pain on these patients and to…

Genetic architecture of congenital hypogonadotropic hypogonadism: insights from analysis of a Portuguese cohort Open

Josianne Nuñes Carriço, Catarina Gonçalves, Asma Al-Naama, Najeeb Syed, José Maria Aragüés , et al. · 2024

STUDY QUESTION What is the contribution of genetic defects in Portuguese patients with congenital hypogonadotropic hypogonadism (CHH)? SUMMARY ANSWER Approximately one-third of patients with CHH were found to have a genetic cause for their…

From Bariatric Surgery to Conception: The Ideal Timing to Optimize Fetal Weight Open

Ana Carreira, Bárbara Fernandes Costa de Araújo, Mariana Lavrador, Inês Vieira, Dírcea Rodrigues , et al. · 2023

Purpose Bariatric surgery (BS) increases the risk of small for gestational age (SGA) neonates. Guidelines recommend postponing pregnancy for 12–24 months, but optimal surgery-to-conception interval (BSCI) remains uncertain. We aimed to eva…

Acute kidney injury: a strong risk factor for hypoglycaemia in hospitalized patients with type 2 diabetes Open

Ana Carreira, Pedro Castro, Filipe Mira, Miguel Melo, Pedro Vianna Caldas Ribeiro , et al. · 2023

Aims Acute kidney injury (AKI) is highly prevalent during hospitalization of patients with type 2 diabetes (T2D). We aimed to assess the impact of AKI and its severity and duration on the risk of hypoglycaemia in hospitalized patients with…

Pregnancy Outcomes After Bariatric Surgery: Should We Favour Restrictive Procedures in Women of Reproductive Age? Open

Bárbara Fernandes Costa de Araújo, Ana Carreira, Mariana Lavrador, Inês Vieira, Dírcea Rodrigues , et al. · 2023

Introduction: Bariatric surgery (BS) is frequently performed in women of reproductive age, and is often associated with nutritional deficiencies and increased risk of adverse outcomes during pregnancy, such as small for gestational age (SG…

Hypoglycemia unawareness in type 1 diabetes patients using intermittent continuous glucose monitoring: Identification of risk factors and glycemic patterns Open

Inês Vieira, Luísa Barros, Carla F. Baptista, Miguel Melo, Dírcea Rodrigues , et al. · 2022

Our sample had a significative prevalence of hypoglycemia unawareness which increased with longer diabetes duration. iCGM data can be indicative of this problem, with a mean hypoglycemia duration ≥106.5 min being suggestive, albeit unspeci…

Correction to: Flash glucose monitoring and glycemic control in type 1 diabetes with subcutaneous insulin infusion Open

Sara Pinheiro, Margarida Bastos, Luísa Barros, Miguel Melo, Isabel Paiva · 2022

Heterogeneity amongst GLP-1 RA cardiovascular outcome trials results: can definition of established cardiovascular disease be the missing link? Open

Miguel Melo, Cristina Gavina, José Silva‐Nunes, Luís Andrade, Davide Carvalho · 2021

Genetic Determinants for Prediction of Outcome of Patients with Papillary Thyroid Carcinoma Open

Antónia Povoa, Elisabete Teixeira, María Rosa Bella, Rui Batısta, Ana Pestana , et al. · 2021

Papillary thyroid carcinoma (PTC) usually presents an excellent prognosis, but some patients present with aggressive metastatic disease. BRAF, RAS, and TERT promoter (TERTp) genes are altered in PTC, and their impact on patient outcomes re…

Adult-onset autoimmune diabetes: comparative analysis of classical and latent presentation Open

Lúcia Fadiga, Joana Saraiva, Diana Catarino, João Frade, Miguel Melo , et al. · 2020

Adult-onset autoimmune diabetes: comparative analysis of classical and latent presentation Open

Lúcia Fadiga, Joana Saraiva, Diana Catarino, João Frade, Miguel Melo , et al. · 2020

Introduction: Adult-onset autoimmune diabetes (AID) has two different phenotypes: classic type 1 diabetes mellitus (T1DM), with insulin requirement just after diagnosis, and latent autoimmune diabetes in adults (LADA). The purpose of this …

Clinicopathological Features as Prognostic Predictors of Poor Outcome in Papillary Thyroid Carcinoma Open

Antónia Povoa, Elisabete Teixeira, María Rosa Bella, Miguel Melo, Maria João Oliveira , et al. · 2020

Papillary thyroid cancer (PTC) has an indolent nature and usually excellent prognosis. Some PTC clinicopathological features may contribute to the development of aggressive metastatic disease. In this work, we want to evaluate PTC clinicop…

Tecnologias de realidade virtual imersivas como ferramenta terapêutica para o isolamento social em tempos de pandemia Open

Miguel Melo · 2020

O ano de 2020 apresentou-nos novosdesafios que nunca pensaríamos atravessar.Nomeadamente, uma epidemia global devidoao novo coronavívurs CoViD-19 que impôso isolamento social a uma grande partedo mundo, senão a todo o mundo mesmo.Sendo que…

Positioning sulphonylureas in a modern treatment algorithm for patients with type 2 diabetes: Expert opinion from a European consensus panel Open

Agostino Consoli, Leszek Czupryniak, Rui Duarte, György Jermendy, Alexandra Kautzky‐Willer , et al. · 2020

The large number of pharmacological agents available to treat type 2 diabetes (T2D) makes choosing the optimal drug for any given patient a complex task. Because newer agents offer several advantages, whether and when sulphonylureas (SUs) …

Portuguese-Brazilian evidence-based guideline on the management of hyperglycemia in type 2 diabetes mellitus Open

Marcello Casaccia Bertoluci, João Eduardo Nunes Salles, José Silva‐Nunes, Hermelinda Cordeiro Pedrosa, Rodrigo O. Moreira , et al. · 2020

Maturity-Onset Diabetes of the Young (MODY) in Portugal: Novel GCK, HNFA1 and HNFA4 Mutations Open

Maria Inês Alvelos, Catarina Gonçalves, Eduarda Coutinho, Joana T. Almeida, Margarida Bastos , et al. · 2020

Maturity-onset diabetes of the young (MODY) is a frequently misdiagnosed type of diabetes, which is characterized by early onset, autosomal dominant inheritance, and absence of insulin dependence. The most frequent subtypes are due to muta…

Efeito da empagliflozina para além do controlo glicémico: benefício cardiovascular em doentes com DMT2 e doença cardiovascular estabelecida Open

Pedro Monteiro, Carlos Aguíar, Pedro Matos, José Silva‐Nunes, Rita Birne , et al. · 2019

The prevalence of type 2 diabetes (T2D) continues to increase, and its association with cardiovascular (CV) disease has led to the inclusion of CV endpoints in clinical trials on the treatment of T2D. This article explores the various tria…

Outcome and long-term follow-up of adrenal lesions in multiple endocrine neoplasia type 1 Open

Mara Ventura, Miguel Melo, Francisco Carrilho · 2019

Adrenal tumours are a common feature of MEN1 that can affect more than half of the patients. Most of the tumours are bilateral non-functional lesions, but hormonal secretion may occur and should be promptly identified to reduce the morbidi…

Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome Open

Mara Ventura, Leonor Gomes, Joana Rosmaninho‐Salgado, Luísa Barros, Isabel Paiva , et al. · 2019

Summary Intracranial germinomas are rare tumors affecting mostly patients at young age. Therefore, molecular data on its etiopathogenesis are scarce. We present a clinical case of a male patient of 25 years with an intracranial germinoma a…

Impacto do Uso Prolongado da Terapêutica Subcutânea Contínua com Insulina no Controlo da Diabetes Mellitus Tipo 1 Open

Sergio Vicente de Azevedo, Joana Saraiva, Francisco Caramelo, Lúcia Fadiga, Luísa Barros , et al. · 2019

Introdução: O uso da terapêutica com perfusão subcutânea contínua de insulina na diabetes mellitus tipo 1 é cada vez mais frequente devido aos seus efeitos benéficos no controlo glicémico e na flexibilidade do estilo de vida. Constituiu ob…

Outcome and long-term follow-up of adrenal lesions in multiple endocrine neoplasia type 1 Open

Mara Ventura, Miguel Melo, Francisco Carrilho · 2019

Objective To describe the prevalence, clinical characteristics and outcome of adrenal lesions in long-term follow-up of Multiple endocrine neoplasia type 1 (MEN1) patients. Subjects and methods We retrospectively studied sixteen patients f…

Addison’s disease in antiphospholipid syndrome: a rare complication Open

Diana Oliveira, Mara Ventura, Miguel Melo, Sandra Paiva, Francisco Carrilho · 2018

Summary Addison’s disease (AD) is the most common endocrine manifestation of antiphospholipid syndrome (APS), but it remains a very rare complication of the syndrome. It is caused by adrenal venous thrombosis and consequent hemorrhagic inf…

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