Claudia Buerger
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View article: Dermatologist-like explainable AI enhances melanoma diagnosis accuracy: eye-tracking study
Dermatologist-like explainable AI enhances melanoma diagnosis accuracy: eye-tracking study Open
Artificial intelligence (AI) systems substantially improve dermatologists’ diagnostic accuracy for melanoma, with explainable AI (XAI) systems further enhancing their confidence and trust in AI-driven decisions. Despite these advancements,…
View article: RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling
RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling Open
Arachidonate 15-lipoxygenase type B (ALOX15B) peroxidises polyunsaturated fatty acids to their corresponding fatty acid hydroperoxides, which are subsequently reduced into hydroxy-fatty acids. A dysregulated abundance of these biological l…
View article: Dermatologist-like explainable AI enhances melanoma diagnosis accuracy: eye-tracking study
Dermatologist-like explainable AI enhances melanoma diagnosis accuracy: eye-tracking study Open
Artificial intelligence (AI) systems have substantially improved dermatologists' diagnostic accuracy for melanoma, with explainable AI (XAI) systems further enhancing clinicians' confidence and trust in AI-driven decisions. Despite these a…
View article: PI3K/AKT/mTOR Signaling Network in Human Health and Diseases
PI3K/AKT/mTOR Signaling Network in Human Health and Diseases Open
Transduction of molecular signaling is a fundamental mechanism that allows a living cell to communicate internally with other cells and its environment through chemical or physical signals, thereby maintaining its structural integrity and …
View article: A Novel Epidermis Model Using Primary Hidradenitis Suppurativa Keratinocytes
A Novel Epidermis Model Using Primary Hidradenitis Suppurativa Keratinocytes Open
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. Patients can present with inflammatory nodules, abscesses up to fistulas, or sinus tracts in intertriginous body parts. Occlusion of the sebaceous gland unit leads to it…
View article: Different immortalized keratinocyte cell lines display distinct capabilities to differentiate and reconstitute an epidermis in vitro
Different immortalized keratinocyte cell lines display distinct capabilities to differentiate and reconstitute an epidermis in vitro Open
Dermatological research relies on the availability of suitable models that most accurately reflect the in vivo situation. Primary keratinocytes obtained from skin reduction surgeries are not only limited by availability but have a short li…
View article: The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds
The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds Open
The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway has been implicated in various immune-mediated inflammatory and hyperproliferative dermatoses such as acne, atopic dermatitis,…
View article: mTORC1 Activity in Psoriatic Lesions Is Mediated by Aberrant Regulation through the Tuberous Sclerosis Complex
mTORC1 Activity in Psoriatic Lesions Is Mediated by Aberrant Regulation through the Tuberous Sclerosis Complex Open
In the basal, proliferative layer of healthy skin, the mTOR complex 1 (mTORC1) is activated, thus regulating proliferation while preventing differentiation. When cells leave the proliferative, basal compartment, mTORC1 signaling is turned …
View article: Mechanism of anti‐inflammatory effects of rifampicin in an ex vivo culture system of hidradenitis suppurativa
Mechanism of anti‐inflammatory effects of rifampicin in an ex vivo culture system of hidradenitis suppurativa Open
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of the hair follicles leading to painful lesions, associated with increased levels of pro‐inflammatory cytokines. Numerous guidelines recommend antibiotics like clindamyc…
View article: Cell Volume Regulation in the Epidermis
Cell Volume Regulation in the Epidermis Open
In order to cope with external stressors such as changes in humidity and temperature or irritating substances, the epidermis as the outermost skin layer forms a continuously renewing and ideally intact protective barrier. Under certain cir…
View article: Epidermal mTORC1 Signaling Contributes to the Pathogenesis of Psoriasis and Could Serve as a Therapeutic Target
Epidermal mTORC1 Signaling Contributes to the Pathogenesis of Psoriasis and Could Serve as a Therapeutic Target Open
Although modern biologics targeting different inflammatory mediators show promising therapeutic success, comprehensive knowledge about the molecular events in psoriatic keratinocytes that contribute to the pathogenesis and could serve as t…
View article: Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation
Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation Open
Psoriasis is a frequent and often severe inflammatory skin disease, characterized by altered epidermal homeostasis. Since we found previously that Akt/mTOR signaling is hyperactivated in psoriatic skin, we aimed at elucidating the role of …