Jun Chen
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View article: Comprehensive management of immune-related hemolytic anemia in a patient with acute cholangitis: A case report
Comprehensive management of immune-related hemolytic anemia in a patient with acute cholangitis: A case report Open
Rationale: Immune-associated hemolytic anemia is an uncommon and potentially life-threatening complication in patients with choledocholithiasis and acute cholangitis. Its occurrence during the perioperative period remains rarely reported. …
View article: Association between C-reactive protein-triglyceride glucose index and NAFLD in US adults: A nationally cross-sectional study using NHANES 2017-2020 data
Association between C-reactive protein-triglyceride glucose index and NAFLD in US adults: A nationally cross-sectional study using NHANES 2017-2020 data Open
The C-reactive protein-triglyceride glucose index (CTI) is a novel biomarker for assessing insulin resistance and the severity of inflammation. However, its association with nonalcoholic fatty liver disease in United States adults has not …
View article: A case report on severe atypical bullous erysipelas induced by Escherichia coli in an immunosuppressed individual
A case report on severe atypical bullous erysipelas induced by Escherichia coli in an immunosuppressed individual Open
A 60-year-old female patient with a prolonged history of immunosuppression due to a 20-year condition of rheumatoid arthritis, managed with long-term glucocorticoids and immunosuppressants, developed atypical erysipelas caused by Escherich…
View article: Single high-dose liposomal amphotericin B plus B/F/TAF for AIDS-associated talaromycosis in China: a multicentre randomised controlled trial protocol
Single high-dose liposomal amphotericin B plus B/F/TAF for AIDS-associated talaromycosis in China: a multicentre randomised controlled trial protocol Open
Introduction Talaromycosis is a severe fungal infection caused by Talaromyces marneffei that predominantly affects people living with HIV (PLWH), particularly in southern China where it contributes substantially to AIDS-related mortality. …
View article: Safety and Efficacy of SHURUI Single-Port Serpentine-Arm Robotic Surgery System in Lung Surgery: A Prospective Single-Centre Study
Safety and Efficacy of SHURUI Single-Port Serpentine-Arm Robotic Surgery System in Lung Surgery: A Prospective Single-Centre Study Open
Objectives The integration of robot-assisted thoracic surgery (RATS) and uniportal video-assisted thoracic surgery (VATS) is poised to become a key direction for future advancements. The SHURUI single-port (SP) Robotic Surgery System, Chin…
View article: The association between C-reactive protein-to-lymphocyte ratio and telomere length: A cross-sectional population-based study
The association between C-reactive protein-to-lymphocyte ratio and telomere length: A cross-sectional population-based study Open
The association of inflammation and telomere length (TL) have drawn much attention. However, the association between the C-reactive protein-to-lymphocyte ratio (CLR) and TL has never been reported before. The authors aimed to investigate t…
View article: Evaluation of ten diagnostic models for metabolic dysfunction-associated fatty liver disease in lean people living with HIV
Evaluation of ten diagnostic models for metabolic dysfunction-associated fatty liver disease in lean people living with HIV Open
Background This study aimed to investigate the prevalence of lean metabolic dysfunction-associated fatty liver disease (lean MAFLD) in people living with HIV (PLWH) and to evaluate the performance of ten diagnostic models in identifying MA…
View article: Assessment of knowledge, attitudes, and practices regarding TB prevention and treatment among college students in Wuhan, central China
Assessment of knowledge, attitudes, and practices regarding TB prevention and treatment among college students in Wuhan, central China Open
Background Tuberculosis (TB) is recognized as a serious public health concern in many developing countries. As the new main force and inheritors of national health construction, college students bear important social responsibilities and m…
View article: The impact of adverse childhood experiences on cardiovascular disease risk in middle-aged and older adults
The impact of adverse childhood experiences on cardiovascular disease risk in middle-aged and older adults Open
ACE exposure is strongly associated with elevated CVD risk in later life among Chinese adults, independent of adult socioeconomic position, behaviors, and health conditions. Findings highlight the critical need for trauma-informed public h…
View article: An ABF5b‐HsfA2h/HsfC2a‐NCED2b/POD4/HSP26 module integrates multiple signaling pathway to modulate heat stress tolerance in wheat
An ABF5b‐HsfA2h/HsfC2a‐NCED2b/POD4/HSP26 module integrates multiple signaling pathway to modulate heat stress tolerance in wheat Open
Summary Heat stress caused by increasing global temperature has become a major factor limiting yield in wheat. Heat shock transcription factors (Hsfs), as the primary regulators in plant responses to heat stress, play essential roles in mo…
View article: <scp>VGF</scp> ‐Derived <scp>TLQP</scp> ‐21 Ameliorates Tumor Progression, Pain, and Depression‐Like Behaviors in an Orthotopic Mouse Model of Pancreatic Ductal Adenocarcinoma
<span>VGF</span> ‐Derived <span>TLQP</span> ‐21 Ameliorates Tumor Progression, Pain, and Depression‐Like Behaviors in an Orthotopic Mouse Model of Pancreatic Ductal Adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer associated with severe pain and depression. Neuropeptide VGF (non‐acronymic) exhibits robust expression in the pancreas and brain, known for its modulatory roles in metabolic …
View article: Prevalence and Risk Factors of Liver Fibrosis Among People With HIV and Metabolic Dysfunction–Associated Steatotic Liver Disease
Prevalence and Risk Factors of Liver Fibrosis Among People With HIV and Metabolic Dysfunction–Associated Steatotic Liver Disease Open
Background We aimed to investigate the prevalence of liver fibrosis and identify the associated risk factors among people with HIV (PWH) and metabolic dysfunction–associated steatotic liver disease (MASLD). Methods Abdominal ultrasonograph…
View article: ALPHA/BETA HYDROLASE DOMAIN CONTAINING 5 SUPPORTS GLUCOSE-STIMULATED-LIPOLYSIS AND INSULIN SECRETION IN PANCREATIC BETA CELLS
ALPHA/BETA HYDROLASE DOMAIN CONTAINING 5 SUPPORTS GLUCOSE-STIMULATED-LIPOLYSIS AND INSULIN SECRETION IN PANCREATIC BETA CELLS Open
PNPLA2 (aka adipose triglyceride lipase) is the rate limiting enzyme of triglyceride (TG) catabolism at the surface of lipid droplets (LDs). Lipolysis by PNPLA2 increases with glucose in pancreatic beta cells and produces metabolites that …
View article: Predictive survival modelings for HIV-related cryptococcosis: comparing machine learning approaches
Predictive survival modelings for HIV-related cryptococcosis: comparing machine learning approaches Open
Introduction HIV-associated cryptococcosis is marked by unpredictable disease trajectories and persistently high mortality rates worldwide. Although improved risk stratification and tailored clinical management are urgently needed to enhan…
View article: Acupuncture attenuates experimental autoimmune thyroiditis by modulating intestinal microbiota and palmitic acid metabolism
Acupuncture attenuates experimental autoimmune thyroiditis by modulating intestinal microbiota and palmitic acid metabolism Open
Introduction Autoimmune thyroiditis (AIT) is a common and chronic autoimmune disease. Recent evidence indicates that serum metabolites and dysbiosis of the intestinal microbiota are associated with AIT, with the underlying mechanism involv…
View article: LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis
LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis Open
LGR6 significantly contributes to the protective effects on IVDD by modulating macrophage efferocytosis, enhancing ECM synthesis, and reducing apoptosis in NPCs. These findings highlight that LGR6 could be a promising therapeutic target fo…
View article: Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells: Erratum
Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells: Erratum Open
[This corrects the article DOI: 10.7150/thno.37745.].
View article: Somatic embryogenetic receptor kinase <scp>TaSERL2</scp> regulates heat stress tolerance in wheat by influencing <scp>TaBZR2</scp> protein stability and transcriptional activity
Somatic embryogenetic receptor kinase <span>TaSERL2</span> regulates heat stress tolerance in wheat by influencing <span>TaBZR2</span> protein stability and transcriptional activity Open
Summary Heat stress is a major factor limiting crop yield, a challenge intensified by climate change. Initial findings indicate that BES1/BZR1 may use heat shock to regulate plant thermal adaptability independently of BIN2‐mediated brassin…
View article: Monocyte distribution width (MDW) as a reliable diagnostic biomarker for sepsis in patients with HIV
Monocyte distribution width (MDW) as a reliable diagnostic biomarker for sepsis in patients with HIV Open
Sepsis is a leading cause of death among patients with HIV, but early diagnosis remains a challenge. This study evaluates the diagnostic performance of monocyte distribution width (MDW) in detecting sepsis in patients with HIV. A prospecti…
View article: The protective role of cannabidiol in stress-induced liver injury: modulating oxidative stress and mitochondrial damage
The protective role of cannabidiol in stress-induced liver injury: modulating oxidative stress and mitochondrial damage Open
Background Stress-induced liver injury, resulting from acute or chronic stress, is associated with oxidative stress and inflammation. The endocannabinoid system, particularly cannabinoid receptor 2 (CB 2 R), plays a crucial role in liver d…
View article: Analysis of intracranial lesions in patients with HIV-associated cryptococcal meningitis
Analysis of intracranial lesions in patients with HIV-associated cryptococcal meningitis Open
Background Intracranial imaging abnormalities are commonly observed in patients suffering from HIV-associated cryptococcal meningitis, both before and during the treatment period. This study aims to analyze the prevalence, origins, radiolo…
View article: Treatment response of patients with tuberculosis and HIV co-infection: a retrospective analysis of secondary data from Shanghai, China, 2010–2020
Treatment response of patients with tuberculosis and HIV co-infection: a retrospective analysis of secondary data from Shanghai, China, 2010–2020 Open
Background: At present, there is a need for more substantial real-world evidence on the factors influencing the effectiveness of tuberculosis (TB) treatment in HIV/TB co-infected patients. Objectives: This retrospective study aims to ident…
View article: P1220 Circulating Metabolite Signatures Linking Physical Activity to Inflammatory Bowel Disease Risk and Interactions with Genetic Susceptibility
P1220 Circulating Metabolite Signatures Linking Physical Activity to Inflammatory Bowel Disease Risk and Interactions with Genetic Susceptibility Open
Background Recent studies have demonstrated the protective effect of physical activity on incident IBD, but the underlying mechanism remain unclear. Here, large-scale circulating metabolomics data was used to identify a metabolic signature…
View article: P0500 Multi-Module Metaformer System for Distinguishing Crohn’s Disease from Intestinal Tuberculosis
P0500 Multi-Module Metaformer System for Distinguishing Crohn’s Disease from Intestinal Tuberculosis Open
Background Distinguishing Crohn’s Disease (CD) from Intestinal Tuberculosis (ITB) through endoscopy can be particularly challenging, especially for junior physicians or those in resource-limited settings. Accurate differentiation is essent…
View article: Risk Assessment of Cardiovascular Disease in HIV Infected Individuals Receiving Antiretroviral Therapy — Shanghai Municipality, China, 2023
Risk Assessment of Cardiovascular Disease in HIV Infected Individuals Receiving Antiretroviral Therapy — Shanghai Municipality, China, 2023 Open
These findings underscore both the necessity and urgency of implementing systematic CVD risk screening and intervention programs for HIV population. Furthermore, the study emphasizes the critical need to develop CVD screening tools specifi…
View article: Knowledge, attitude, and practice of psoriatic arthritis among patients with psoriasis
Knowledge, attitude, and practice of psoriatic arthritis among patients with psoriasis Open
Introduction This study aimed to investigate the knowledge, attitude and practice (KAP) of psoriatic arthritis among patients with psoriasis. The KAP questionnaire is a widely used tool in public health research, designed to assess individ…
View article: Structure-adaptive canonical correlation analysis for microbiome multi-omics data
Structure-adaptive canonical correlation analysis for microbiome multi-omics data Open
Sparse canonical correlation analysis (sCCA) has been a useful approach for integrating different high-dimensional datasets by finding a subset of correlated features that explain the most correlation in the data. In the context of microbi…
View article: Lipid droplet protein Perilipin 2 is critical for the regulation of insulin secretion through beta cell lipophagy and glucagon expression in pancreatic islets
Lipid droplet protein Perilipin 2 is critical for the regulation of insulin secretion through beta cell lipophagy and glucagon expression in pancreatic islets Open
Knockdown (KD) of lipid droplet (LD) protein perilipin 2 (PLIN2) in beta cells impairs glucose-stimulated insulin secretion (GSIS) and mitochondrial function. Here, we addressed a pathway responsible for compromised mitochondrial integrity…