Claudia E. Ramirez
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View article: SAT-527 Addition of Dulaglutide to Immunosuppressive Therapy Markedly Reduces Insulin Requirements in a Patient with Insulin Antibody-Mediated Resistance
SAT-527 Addition of Dulaglutide to Immunosuppressive Therapy Markedly Reduces Insulin Requirements in a Patient with Insulin Antibody-Mediated Resistance Open
Disclosure: M.M. Fatakdawala: None. R. Gaba: None. C.E. Ramirez Bustamante: None. A. Balasubramanyam: None. N. Ram: None. J. Faruqi: None. Background: Insulin antibody-mediated resistance is an autoimmune condition wherein autoantibodies b…
View article: Liver-specific Expression of HIV-1 Viral Protein R Causes Hepatic Steatosis and Glucose Intolerance in Male Mice
Liver-specific Expression of HIV-1 Viral Protein R Causes Hepatic Steatosis and Glucose Intolerance in Male Mice Open
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized in people with HIV (PWH), with both HIV and antiretroviral therapy contributing to liver damage and glucose intolerance. However, the ro…
View article: The microRNA miR-30a blocks adipose tissue fibrosis accumulation in obesity
The microRNA miR-30a blocks adipose tissue fibrosis accumulation in obesity Open
White adipose tissue (WAT) fibrosis occurring in obesity contributes to the inflammatory and metabolic comorbidities of insulin resistance and type 2 diabetes, yet the mechanisms involved remain poorly understood. Here, we report a role fo…
View article: Adipose Tissue Dysfunction and Energy Balance Paradigms in People Living With HIV
Adipose Tissue Dysfunction and Energy Balance Paradigms in People Living With HIV Open
Over the past 4 decades, the clinical care of people living with HIV (PLWH) evolved from treatment of acute opportunistic infections to the management of chronic, noncommunicable comorbidities. Concurrently, our understanding of adipose ti…
View article: Heightened levels of plasma growth differentiation factor 15 in men living with HIV
Heightened levels of plasma growth differentiation factor 15 in men living with HIV Open
Plasma biomarkers that reflect energy balance disorders in people living with HIV (PLWH) remain limited. Growth differentiation factor 15 (GDF15) abundance in plasma of mice and humans induces negative energy balance but also becomes highl…
View article: Hypertension in Obese Black Women is Not Caused by Increased Sympathetic Vascular Tone
Hypertension in Obese Black Women is Not Caused by Increased Sympathetic Vascular Tone Open
Background Black women have one of the highest prevalence rates of hypertension and obesity in the United States. We previously reported that sympathetic activation induced by obesity is a significant contributor to hypertension in white p…
View article: A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition
A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition Open
Context: The scavenger receptor CD36 influences the endothelial nitric oxide-cGMP pathway in vitro. Genetic variants that alter CD36 level are common in African Americans (AAs), a population at high risk of endothelial dysfunction. Objecti…
View article: Comparative effects of immediate‐release and extended‐release aspirin on basal and bradykinin‐stimulated excretion of thromboxane and prostacyclin metabolites
Comparative effects of immediate‐release and extended‐release aspirin on basal and bradykinin‐stimulated excretion of thromboxane and prostacyclin metabolites Open
A goal of aspirin therapy is to inhibit thromboxane production and platelet aggregation without inhibiting endothelial production of the vasodilator and anti‐thrombotic prostacyclin. This study tested the hypothesis that extended‐release a…