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View article: Putting the PASC Score to the Test: Clinical vs. Statistical Accuracy in Long COVID Diagnosis
Putting the PASC Score to the Test: Clinical vs. Statistical Accuracy in Long COVID Diagnosis Open
Objective To validate the RECOVER Post-Acute Sequelae of SARS-CoV-2 infection (PASC) score in a cohort of patients who develop long COVID (LC) or fully recover while iteratively improving the tool’s sensitivity and specificity. Methods A c…
View article: Cardioprotection Reloaded: Reflections on 40 Years of Research
Cardioprotection Reloaded: Reflections on 40 Years of Research Open
Over the past four decades, cardioprotective research has revealed an extraordinary complexity of cellular and molecular mechanisms capable of mitigating ischemia/reperfusion injury (IRI). Among these, ischemic conditioning has emerged as …
View article: Produção de biocorantes microbianos para a indústria têxtil
Produção de biocorantes microbianos para a indústria têxtil Open
A produção de biocorantes microbianos são uma alternativa sustentável aos corantessintéticos utilizados na indústria têxtil, podendo ser utilizados como uma importanteferramenta biotecnológica uma vez que a biodiversidade microbiana tem a …
View article: Macrophage and cardiomyocyte roles in cardioprotection: Exploiting the NLRP3 Inflammasome inhibitor INF150
Macrophage and cardiomyocyte roles in cardioprotection: Exploiting the NLRP3 Inflammasome inhibitor INF150 Open
While INF150 effectively shielded macrophages from LPS/ATP challenges, it failed to penetrate H9c2 and differentiated H9c2, even at high concentrations (no changes in pyroptosis markers induced by H/R). In the isolated mice heart model, IN…
View article: Endothelial Dysfunction: Redox Imbalance, NLRP3 Inflammasome, and Inflammatory Responses in Cardiovascular Diseases
Endothelial Dysfunction: Redox Imbalance, NLRP3 Inflammasome, and Inflammatory Responses in Cardiovascular Diseases Open
Endothelial dysfunction (ED) is characterized by an imbalance between vasodilatory and vasoconstrictive factors, leading to impaired vascular tone, thrombosis, and inflammation. These processes are critical in the development of cardiovasc…
View article: PCSK9 Expression in Vascular Smooth Muscle Cells: Role of Insulin Resistance and High Glucose
PCSK9 Expression in Vascular Smooth Muscle Cells: Role of Insulin Resistance and High Glucose Open
Beyond the regulation of cholesterol metabolism, a number of extrahepatic functions of proprotein convertase subtilisin/kexin type 9 (PCSK9) have been increasingly identified. The main purpose of this study was to verify whether PCSK9 expr…
View article: Stay connected: The myoendothelial junction proteins in vascular function and dysfunction
Stay connected: The myoendothelial junction proteins in vascular function and dysfunction Open
The appropriate regulation of peripheral vascular tone is crucial for maintaining tissue perfusion. Myoendothelial junctions (MEJs), specialized connections between endothelial cells and vascular smooth muscle cells, are primarily located …
View article: A Personalized Approach to Vitamin D Supplementation in Cardiovascular Health Beyond the Bone: An Expert Consensus by the Italian National Institute for Cardiovascular Research
A Personalized Approach to Vitamin D Supplementation in Cardiovascular Health Beyond the Bone: An Expert Consensus by the Italian National Institute for Cardiovascular Research Open
Vitamin D is increasingly recognized for its role in cardiovascular health beyond its well-established effects on bone metabolism. This review synthesizes findings from observational studies, interventional trials, and meta-analyses to cla…
View article: An intrinsic mechanism of metabolic tuning promotes cardiac resilience to stress
An intrinsic mechanism of metabolic tuning promotes cardiac resilience to stress Open
View article: Novel NLRP3 inhibitor INF195: Low doses provide effective protection against myocardial ischemia/reperfusion injury
Novel NLRP3 inhibitor INF195: Low doses provide effective protection against myocardial ischemia/reperfusion injury Open
INF195 reduces NLRP3-induced pyroptosis in human macrophages. Heart pre-treatment with 5 and 10-μM INF195 significantly reduces both infarct size and IL-1β levels. Data suggest that intracardiac NLRP3 activation contributes to IRI and that…
View article: Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies
Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies Open
View article: Enhancing Heart Transplantation: Utilizing Gas-Loaded Nanocarriers to Mitigate Cold/Hypoxia Stress
Enhancing Heart Transplantation: Utilizing Gas-Loaded Nanocarriers to Mitigate Cold/Hypoxia Stress Open
Gas-loaded nanocarriers (G-LN) show promise in improving heart transplantation (HTx) outcomes. Given their success in reducing cell death during normothermic hypoxia/reoxygenation (H/R) in vitro, we tested their integration into cardiopleg…
View article: Enhancing Vitamin D3 Efficacy: Insights from Complexation with Cyclodextrin Nanosponges and Its Impact on Gut–Brain Axes in Physiology and IBS Syndrome
Enhancing Vitamin D3 Efficacy: Insights from Complexation with Cyclodextrin Nanosponges and Its Impact on Gut–Brain Axes in Physiology and IBS Syndrome Open
Vitamin D3 (VitD3) plays a crucial role in various cellular functions through its receptor interaction. The biological activity of Vitamin D3 can vary based on its solubility and stability. Thus, the challenge lies in maximizing its biolog…
View article: Expanding the Frontiers of Guardian Antioxidant Selenoproteins in Cardiovascular Pathophysiology
Expanding the Frontiers of Guardian Antioxidant Selenoproteins in Cardiovascular Pathophysiology Open
Significance: Physiological levels of reactive oxygen and nitrogen species (ROS/RNS) function as fundamental messengers for many cellular and developmental processes in the cardiovascular system. ROS/RNS involved in cardiac redox-signaling…
View article: Management of cancer patients at high and very-high risk of cardiotoxicity: Main questions and answers
Management of cancer patients at high and very-high risk of cardiotoxicity: Main questions and answers Open
In recent years, important advances have been made in the field of Cardio-Oncology. The 2022 ESC Guidelines on Cardio-Oncology proposed a baseline cardiovascular risk stratification for cancer patients and preventive strategies in patients…
View article: Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation
Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation Open
Inspired by the recent advancements in understanding the binding mode of sulfonylurea-based NLRP3 inhibitors to the NLRP3 sensor protein, we developed new NLRP3 inhibitors by replacing the central sulfonylurea moiety with different heteroc…
View article: Clinical Applications for Gasotransmitters in the Cardiovascular System: Are We There Yet?
Clinical Applications for Gasotransmitters in the Cardiovascular System: Are We There Yet? Open
Ischemia is the underlying mechanism in a wide variety of acute and persistent pathologies. As such, understanding the fine intracellular events occurring during (and after) the restriction of blood supply is pivotal to improving the outco…
View article: Inhibitors of NLRP3 Inflammasome in Ischemic Heart Disease: Focus on Functional and Redox Aspects
Inhibitors of NLRP3 Inflammasome in Ischemic Heart Disease: Focus on Functional and Redox Aspects Open
Myocardial ischemia-reperfusion injury (MIRI) is caused by several mechanisms, including the production of reactive oxygen species (ROS), altered cellular osmolarity, and inflammatory response. Calcium overload, altered oxygen levels, and …
View article: Oxygen Nanocarriers for Improving Cardioplegic Solution Performance: Physico-Chemical Characterization
Oxygen Nanocarriers for Improving Cardioplegic Solution Performance: Physico-Chemical Characterization Open
Nanocarriers for oxygen delivery have been the focus of extensive research to ameliorate the therapeutic effects of current anti-cancer treatments and in the organ transplant field. In the latter application, the use of oxygenated cardiopl…
View article: Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation
Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation Open
View article: Platelets and Cardioprotection: The Role of Nitric Oxide and Carbon Oxide
Platelets and Cardioprotection: The Role of Nitric Oxide and Carbon Oxide Open
Nitric oxide (NO) and carbon monoxide (CO) represent a pair of biologically active gases with an increasingly well-defined range of effects on circulating platelets. These gases interact with platelets and cells in the vessels and heart an…
View article: Developing New Cyclodextrin-Based Nanosponges Complexes to Improve Vitamin D Absorption in an In Vitro Study
Developing New Cyclodextrin-Based Nanosponges Complexes to Improve Vitamin D Absorption in an In Vitro Study Open
Vitamin D plays an important role in numerous cellular functions due to the ability to bind the Vitamin D receptor (VDR), which is present in different tissues. Several human diseases depend on low vitamin D3 (human isoform) serum level, a…
View article: Pathways for Cardioprotection in Perspective: Focus on Remote Conditioning and Extracellular Vesicles
Pathways for Cardioprotection in Perspective: Focus on Remote Conditioning and Extracellular Vesicles Open
Despite the development of cutting-edge treatments, coronary artery disease (CAD) morbidity and mortality rates remain present at high levels. Therefore, new cardioprotective approaches are crucial to improve the health of patients. To dat…
View article: Manifestações pulmonares em crianças e adolescentes hospitalizados com suspeita de Covid-19: um estudo caso-controle
Manifestações pulmonares em crianças e adolescentes hospitalizados com suspeita de Covid-19: um estudo caso-controle Open
View article: Editorial: Cardioprotection, sex and gender differences
Editorial: Cardioprotection, sex and gender differences Open
EDITORIAL article Front. Physiol., 31 August 2022Sec. Clinical and Translational Physiology https://doi.org/10.3389/fphys.2022.940058
View article: The dual role of mesenchymal stem cell-derived exosomes modulates the phagocytic activity of macrophages and promotes cardiac recovery after heart attack
The dual role of mesenchymal stem cell-derived exosomes modulates the phagocytic activity of macrophages and promotes cardiac recovery after heart attack Open
View article: The Activity of Ten Natural Extracts Combined in a Unique Blend to Maintain Cholesterol Homeostasis—In Vitro Model
The Activity of Ten Natural Extracts Combined in a Unique Blend to Maintain Cholesterol Homeostasis—In Vitro Model Open
Background: Hypercholesterolemia is a major cause of cardiovascular disease and statins, the HMGCoA inhibitors, are the most prescribed drugs. Statins reduce the production of hepatic cholesterol, leading to greater expression of the LDL r…
View article: A TRICk to Improve the Effectiveness of RIC: Role of Limb Temperature in Enhancing the Effectiveness of Remote Ischemic Conditioning
A TRICk to Improve the Effectiveness of RIC: Role of Limb Temperature in Enhancing the Effectiveness of Remote Ischemic Conditioning Open
Background: Treatment of myocardial ischemia/reperfusion (IR) injury is still an unmet clinical need. A large variability of remote ischemic conditioning (RIC) protection has been reported; however, no studies have considered the temperatu…
View article: Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function
Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function Open
Ischemia–reperfusion injury (IRI) is one of the biggest challenges for cardiovascular researchers given the huge death toll caused by myocardial ischemic disease. Cardioprotective conditioning strategies, namely pre- and post-conditioning …
View article: Percutaneous Coronary Intervention (PCI) Reprograms Circulating Extracellular Vesicles from ACS Patients Impairing Their Cardio-Protective Properties
Percutaneous Coronary Intervention (PCI) Reprograms Circulating Extracellular Vesicles from ACS Patients Impairing Their Cardio-Protective Properties Open
Extracellular vesicles (EVs) are promising therapeutic tools in the treatment of cardiovascular disorders. We have recently shown that EVs from patients with Acute Coronary Syndrome (ACS) undergoing sham pre-conditioning, before percutaneo…