Cláudia Henrique da Costa
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View article: Analysis of the Relationship Between CHRNA3/5 and EPHX1 Polymorphisms to Tobacco Intake and Development of Chronic Obstructive Pulmonary Disease (COPD)
Analysis of the Relationship Between CHRNA3/5 and EPHX1 Polymorphisms to Tobacco Intake and Development of Chronic Obstructive Pulmonary Disease (COPD) Open
Background: Chronic obstructive pulmonary disease (COPD) is a complex condition influenced by both environmental and genetic factors. Among the genetic determinants, polymorphisms in the CHRNA3/5 and EPHX1 genes have been implicated in nic…
View article: A Simplified Three-Item Clinical Score to Identify Exertional Hypoxemia in Fibrotic Interstitial Lung Disease: A Real-World Cohort Study
A Simplified Three-Item Clinical Score to Identify Exertional Hypoxemia in Fibrotic Interstitial Lung Disease: A Real-World Cohort Study Open
Background: Exertional oxygen desaturation (SpO2 ≤ 88%) during the six-minute walk test (6MWT) is a key prognostic marker in interstitial lung disease (ILD), yet access to the test is often limited in clinical practice. Developing simple, …
View article: Epidemiological burden and mortality of idiopathic pulmonary fibrosis in Brazil: historical trends and future outlook
Epidemiological burden and mortality of idiopathic pulmonary fibrosis in Brazil: historical trends and future outlook Open
View article: Avaliação crítica da abordagem paleontológica em livros didáticos dos anos finais do ensino fundamental
Avaliação crítica da abordagem paleontológica em livros didáticos dos anos finais do ensino fundamental Open
A Paleontologia é uma ciência fundamental no processo de ensino-aprendizagem para a compreensão de processos naturais complexos e para a formação de cidadãos críticos, mas seu conhecimento ainda está restrito ao meio acadêmico. Este trabal…
View article: Changes in Lung Ultrasound in Systemic Sclerosis Before and After Rehabilitation: A Comparative Study Between People with and Without Interstitial Lung Disease
Changes in Lung Ultrasound in Systemic Sclerosis Before and After Rehabilitation: A Comparative Study Between People with and Without Interstitial Lung Disease Open
There is limited research on the impact of a physiotherapy-guided rehabilitation program (PGRP) on lung structure in systemic sclerosis (SSc). Lung ultrasound (LUS) has been used for over a decade to identify interstitial lung disease asso…
View article: Brazilian Thoracic Association recommendations for the management of lymphangioleiomyomatosis
Brazilian Thoracic Association recommendations for the management of lymphangioleiomyomatosis Open
Lymphangioleiomyomatosis (LAM) is a rare disease, characterized as a low-grade neoplasm with metastatic potential that mainly affects women of reproductive age, in which there is proliferation of atypical smooth muscle cells (LAM cells) an…
View article: Longitudinal changes in the 6-minute walk test and the Glittre-activities of daily living test in adults with cystic fibrosis
Longitudinal changes in the 6-minute walk test and the Glittre-activities of daily living test in adults with cystic fibrosis Open
With the increasing use of highly effective modulator therapy (HEMT) in adults with cystic fibrosis (awCF), it is necessary to determine the evolution of the most dynamic physiological markers of this disease, such as the 6-minute walk tes…
View article: Ultrasonography as a way of evaluating the diaphragm muscle in patients with chronic obstructive pulmonary disease
Ultrasonography as a way of evaluating the diaphragm muscle in patients with chronic obstructive pulmonary disease Open
The respiratory muscles in chronic obstructive pulmonary disease (COPD) patients have reduced strength and resistance, leading to loss of the functional ability of these muscles. Lung hyperinflation is one of the main alterations, and air …
View article: Questionnaire and polysomnographic evaluation of obstructive sleep apnea in a cohort of post-COVID-19 patients
Questionnaire and polysomnographic evaluation of obstructive sleep apnea in a cohort of post-COVID-19 patients Open
To evaluate the efficiency of 5 screening questionnaires for obstructive sleep apnea (OSA), OSA frequency, and the association between OSA and COVID-19 severity in recent COVID-19 cases, and to compare the use of the oxygen desaturation in…
View article: Positron emission tomography/computed tomography (PET/CT) as predictor of sarcoidosis activity: A case series
Positron emission tomography/computed tomography (PET/CT) as predictor of sarcoidosis activity: A case series Open
Introduction: Sarcoidosis is a multisystemic granulomatous disease that can present different clinical and radiological manifestations, while nospecific exams exist to monitor its activity and spontaneous or drug-induced remission. Objecti…
View article: Association between swallowing dynamics, tongue pressure and pulmonary function in patients with idiopathic pulmonary fibrosis
Association between swallowing dynamics, tongue pressure and pulmonary function in patients with idiopathic pulmonary fibrosis Open
Background Swallowing is a complex process that requires the coordination of muscles in the mouth, pharynx, larynx, and esophagus. Dysphagia occurs when a person has difficulty swallowing. In the case of subjects with respiratory diseases,…
View article: Assessing U-Net Model Performance in Weather Radar-Based Precipitation Nowcasting: A Reflectivity Threshold Analysis
Assessing U-Net Model Performance in Weather Radar-Based Precipitation Nowcasting: A Reflectivity Threshold Analysis Open
Severe weather events pose a global threat, causing property damage and endangering lives. Weather-related disasters account for 50% of all natural and technological disasters. The development of accurate prediction systems are crucial for…
View article: Ultrasonography as a way of evaluating the diaphragm muscle in patients with chronic obstructive pulmonary disease.
Ultrasonography as a way of evaluating the diaphragm muscle in patients with chronic obstructive pulmonary disease. Open
Background: Diaphragmatic mobility (DM) may be reduced in chronic obstructive pulmonary disease (COPD) patients, but little is known about whether this mobility correlates with functional parameters, exercise capacity, and indicators of d…
View article: COPD Patients Exhibit Distinct Gene Expression, Accelerated Cellular Aging, and Bias to M2 Macrophages
COPD Patients Exhibit Distinct Gene Expression, Accelerated Cellular Aging, and Bias to M2 Macrophages Open
COPD, one of world’s leading contributors to morbidity and mortality, is characterized by airflow limitation and heterogeneous clinical features. Three main phenotypes are proposed: overlapping asthma/COPD (ACO), exacerbator, and emphysema…
View article: Gold standard motion analysis system for evaluating jumping performance in rhythmic gymnastics
Gold standard motion analysis system for evaluating jumping performance in rhythmic gymnastics Open
The aim of this study is to investigate the effectiveness, not yet described in the literature, of the gold standard system for motion analysis, to analyse the kinematic and dynamic aspects of the split leap in rhythmic gymnastics performe…
View article: Mortality and comorbidities in patients with bronchiectasis over a 3-year follow-up
Mortality and comorbidities in patients with bronchiectasis over a 3-year follow-up Open
To identify the risk factors associated with all-cause mortality in patients with noncystic fibrosis bronchiectasis (NCFB). This prospective cohort study included 120 adult patients with NCFB, who were regularly treated at a specialized ou…
View article: EFICÁCIA CLÍNICA DO TRANSPLANTE DA MICROBIOTA INTESTINAL EM PACIENTES COM DOENÇA INFLAMATÓRIA INTESTINAL
EFICÁCIA CLÍNICA DO TRANSPLANTE DA MICROBIOTA INTESTINAL EM PACIENTES COM DOENÇA INFLAMATÓRIA INTESTINAL Open
Introdução Desequilíbrio na composição e na função da microbiota gastrointestinal (disbiose) tem um papel importante na etiopatogenia de doenças inflamatórias intestinais (DIIs), e evidências científicas demonstram que fezes são substância…
View article: Not Everything is as it Seems: An Unusual Case of Pyelonephritis
Not Everything is as it Seems: An Unusual Case of Pyelonephritis Open
Urinary tract infection is an important cause of hospitalization, morbidity and mortality, being responsible for an important fraction of health expenses. The main risk factors are urine flow obstruction, urinary catheters, immunosuppressi…
View article: Seletividade alimentar e autismo sob a ótica comportamental: revisão sistemática no JABA
Seletividade alimentar e autismo sob a ótica comportamental: revisão sistemática no JABA Open
O objetivo deste artigo foi identificar, por meio de uma revisão sistemática, a frequência de publicaçõesdo Journal of Applied Behavior Analysis (JABA), no período de 2000 a 2020 que abordassem de uma formaexperimental o efeito do procedim…
View article: Smoking and COVID 19: Analysing this controversy in a Brazilian COVID-19 Reference Centre
Smoking and COVID 19: Analysing this controversy in a Brazilian COVID-19 Reference Centre Open
Introduction: Due to the COVID-19 pandemic, it is extremelyimportant to determine the risk factors that definepatients who are more susceptible to the severe form ofthe disease; however, the observation of supposedly protectivefactors is a…
View article: The impact of healthcare-associated infections on COVID-19 mortality: a cohort study from a Brazilian public hospital
The impact of healthcare-associated infections on COVID-19 mortality: a cohort study from a Brazilian public hospital Open
In this cohort, the strongest risk factor for in-hospital death was the development of nosocomial septic shock. Healthcare-associated infections have a significant impact on mortality rates. Therefore, to have a better outcome, it is impor…
View article: Small airway evaluation in three subjects with alpha-1 antitrypsin deficiency without diagnosed lung disease
Small airway evaluation in three subjects with alpha-1 antitrypsin deficiency without diagnosed lung disease Open
We describe three cases of female subjects (aged 16, 44 and 41 years) with no respiratory symptoms, who have alpha-1 antitripsyn mutation (PiSZ, PiZZ and PiZZ) and who performed traditional pulmonary function tests and the single breath ni…
View article: A inteligência Artificial e o Negócio Eletrónico - Uma visão geral
A inteligência Artificial e o Negócio Eletrónico - Uma visão geral Open
O presente artigo aborda a inteligência artificial e o seu impacto no negócio eletrónico de uma forma geral. O Objetivo do atual artigo é, portanto, analisar a área de conhecimento da Inteligência artificial algumas das suas subáreas e o n…
View article: Progressive fibrosing interstitial lung disease associated with autoimmune rheumatic diseases: a snapshot from Brazil
Progressive fibrosing interstitial lung disease associated with autoimmune rheumatic diseases: a snapshot from Brazil Open
View article: Inequality in Mortality between Black and White Americans by Age, Place, and Cause, and in Comparison to Europe, 1990-2018
Inequality in Mortality between Black and White Americans by Age, Place, and Cause, and in Comparison to Europe, 1990-2018 Open
Although there is a large gap between Black and White American life expectancies, the gap fell 48.9% between 1990-2018, mainly due to mortality declines among Black Americans. We examine age-specific mortality trends and racial gaps in lif…
View article: Additional file 1 of Pulmonary hypertension in systemic sclerosis: diagnosis by systematic screening and prognosis after three years follow-up
Additional file 1 of Pulmonary hypertension in systemic sclerosis: diagnosis by systematic screening and prognosis after three years follow-up Open
Additional file 1.: The results of clinical, laboratory, spirometric, echocardiographic and hemodynamic data.
View article: Clinical and laboratory characteristics in outpatient diagnosis of COVID-19 in healthcare professionals in Rio de Janeiro, Brazil
Clinical and laboratory characteristics in outpatient diagnosis of COVID-19 in healthcare professionals in Rio de Janeiro, Brazil Open
Aims This study aimed to identify the symptoms associated with early stage SARS-CoV-2 (COVID-19) infections in healthcare professionals (HCP) using both clinical and laboratory data. Methods A total of 1,297 patients, admitted between Marc…
View article: European Exposure Model Data Repository
European Exposure Model Data Repository Open
A repository of the exposure data used to develop the ESRM20 exposure models.\n\n\nMore information available in the following publication: Crowley et al. (2020) “Exposure model for European Seismic Risk Assessment,” Earthquake…
View article: <p>Evaluation of the Small Airways in Patients with Chronic Obstructive Pulmonary Disease and Alpha-1 Antitrypsin Deficiency</p>
Evaluation of the Small Airways in Patients with Chronic Obstructive Pulmonary Disease and Alpha-1 Antitrypsin Deficiency Open
Our results suggest that both variables, phase III slope and the ΔN2 750-1250 mL (%), could be related to COPD severity. Therefore, alterations at the distribution of the location of the emphysema could alter the results of closer volume a…
View article: Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study
Symptom variability over the course of the day in patients with stable COPD in Brazil: a real-world observational study Open
Dyspnea was more common in the morning than at night. Having morning or nighttime symptoms was associated with greater daytime symptom severity. Symptom intensity was strongly associated with poor quality of life and with the frequency of …