Claudia Huber
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View article: Antifungal and anti-toxigenic activities of Origanum onites and Thymus capitatus essential oils and ethanolic extracts against mycotoxigenic fungi isolated from barley
Antifungal and anti-toxigenic activities of Origanum onites and Thymus capitatus essential oils and ethanolic extracts against mycotoxigenic fungi isolated from barley Open
With the purpose of identifying biological substances for controlling Aspergillus-caused aflatoxin B1 and ochratoxin A contamination in cereals, particularly in barley, we assessed the efficiencies of Origanum onites and Thymus capitatus e…
View article: Acridocarpus smeathmannii root extracts inhibit human prostate and bladder smooth muscle contraction, porcine arterial vasoconstriction, and cytotoxicity of prostate stromal cells
Acridocarpus smeathmannii root extracts inhibit human prostate and bladder smooth muscle contraction, porcine arterial vasoconstriction, and cytotoxicity of prostate stromal cells Open
Introduction The limited tolerability and efficacy of synthetic drugs have hindered the effective management of lower urinary tract symptoms (LUTSs). In African traditional medicine, species of the genus Acridocarpus (Malpighiaceae) are co…
View article: The legacy of Hans Fischer - revision of one of the largest libraries of pyrroles and porphyrins
The legacy of Hans Fischer - revision of one of the largest libraries of pyrroles and porphyrins Open
View article: Chemoorganoautotrophic lifestyle of the anaerobic enrichment culture N47 growing on naphthalene
Chemoorganoautotrophic lifestyle of the anaerobic enrichment culture N47 growing on naphthalene Open
View article: Benzyl Benzoate Isolation from Acridocarpus smeathmannii (DC.) Guill. & Perr Roots and Its Bioactivity on Human Prostate Smooth Muscle Contractions
Benzyl Benzoate Isolation from Acridocarpus smeathmannii (DC.) Guill. & Perr Roots and Its Bioactivity on Human Prostate Smooth Muscle Contractions Open
Background/Objectives: This study is the first report on isolating a natural benzyl benzoate (nBB) from Acridocarpus smeathmannii (DC.) Guill. & Perr roots. Methods: The structure was verified using GC-MS, HPLC-UV-VIS, and two-dimensional …
View article: The AusAB non-ribosomal peptide synthetase of <i>Staphylococcus aureus</i> preferentially generates phevalin in host-mimicking media
The AusAB non-ribosomal peptide synthetase of <i>Staphylococcus aureus</i> preferentially generates phevalin in host-mimicking media Open
Non-ribosomal peptide synthetases (NRPSs) are modular multidomain enzymes responsible for the biosynthesis of various secondary metabolites in an mRNA template-independent manner. They are predominantly present in bacteria and fungi, where…
View article: Integrated serological surveillance of communicable diseases in the Paraguayan Chaco, 2019
Integrated serological surveillance of communicable diseases in the Paraguayan Chaco, 2019 Open
Objective. To establish baseline seroprevalence of soil-borne, waterborne, and foodborne diseases and to monitor diseases that are eliminated or on the path to elimination in the Paraguayan Chaco. Methods. A total of 1 100 school-age chi…
View article: Benzyl Benzoate Isolation from Acridocarpus smeathmannii (DC.) Roots and Its Bioactivity on Human Prostate Smooth Muscle Contractions
Benzyl Benzoate Isolation from Acridocarpus smeathmannii (DC.) Roots and Its Bioactivity on Human Prostate Smooth Muscle Contractions Open
Background: This study reports the bioactivity of a natural benzyl benzoate (nBB) from Acridocarpus smeathmannii (DC.). Known for its vasodilatory and anti-spasmolytic actions, we investigated the biological effects of nBB on human prostat…
View article: Prevalence and diagnostic accuracy of different diagnostic tests for Chagas disease in an indigenous community of the Paraguayan Chaco
Prevalence and diagnostic accuracy of different diagnostic tests for Chagas disease in an indigenous community of the Paraguayan Chaco Open
Introduction Chagas disease (CD), caused by the protozoan Trypanosoma cruzi (T. cruzi), poses a major health challenge in Paraguay, especially in the resource-limited Chaco region. Rapid diagnostic tests (RDTs) are valuable tools to enhanc…
View article: Protective Factors of Nurses’ Mental Health and Professional Wellbeing During the COVID-19 Pandemic: A Multicenter Longitudinal Study
Protective Factors of Nurses’ Mental Health and Professional Wellbeing During the COVID-19 Pandemic: A Multicenter Longitudinal Study Open
Objective Using a salutogenic approach, this study aimed to identify similarities in the protective factors of nurses’ psychological Quality of Life (QoL) and professional wellbeing (PWB) in four countries and to assess their variability o…
View article: From Zero to Hero: The Cyanide-Free Formation of Amino Acids and Amides from Acetylene, Ammonia and Carbon Monoxide in Aqueous Environments in a Simulated Hadean Scenario
From Zero to Hero: The Cyanide-Free Formation of Amino Acids and Amides from Acetylene, Ammonia and Carbon Monoxide in Aqueous Environments in a Simulated Hadean Scenario Open
Amino acids are one of the most important building blocks of life. During the biochemical process of translation, cells sequentially connect amino acids via amide bonds to synthesize proteins, using the genetic information in messenger RNA…
View article: The AusAB non-ribosomal peptide synthase in<i>Staphylococcus aureus</i>preferentially incorporates exogenous phenylalanine and tyrosine into the aureusimine natural products
The AusAB non-ribosomal peptide synthase in<i>Staphylococcus aureus</i>preferentially incorporates exogenous phenylalanine and tyrosine into the aureusimine natural products Open
Non-ribosomal peptide synthases (NRPS) are modular multidomain enzymes, responsible for the biosynthesis of various secondary metabolites, in a mRNA-template independent manner. They are predominantly present in bacteria and fungi, where t…
View article: Nickel-organo compounds as potential enzyme precursors under simulated early Earth conditions
Nickel-organo compounds as potential enzyme precursors under simulated early Earth conditions Open
The transition from inorganic catalysis through minerals to organic catalysis by enzymes is a necessary step in the emergence of life. Our work is elucidating likely reactions at the earliest moments of Life, prior to the existence of enzy…
View article: C2-addition patterns emerging from acetylene and nickel sulfide in simulated prebiotic hydrothermal conditions
C2-addition patterns emerging from acetylene and nickel sulfide in simulated prebiotic hydrothermal conditions Open
View article: Formation of vesicular structures from fatty acids formed under simulated volcanic hydrothermal conditions
Formation of vesicular structures from fatty acids formed under simulated volcanic hydrothermal conditions Open
Microscopic compartmentalization is beneficial in synthetic chemistry and indispensable for the evolution of life to separate a reactive “inside” from a hydrolyzing “outside”. Here, we show compartmentalization in aqueous solution containi…
View article: Changes in adenoviral chromatin organization precede early gene activation upon infection
Changes in adenoviral chromatin organization precede early gene activation upon infection Open
View article: Formation, stabilization and fate of acetaldehyde and higher aldehydes in an autonomously changing prebiotic system emerging from acetylene
Formation, stabilization and fate of acetaldehyde and higher aldehydes in an autonomously changing prebiotic system emerging from acetylene Open
View article: Anti-Inflammatory and Antioxidative Phytogenic Substances against Secret Killers in Poultry: Current Status and Prospects
Anti-Inflammatory and Antioxidative Phytogenic Substances against Secret Killers in Poultry: Current Status and Prospects Open
Chronic stress is recognized as a secret killer in poultry. It is associated with systemic inflammation due to cytokine release, dysbiosis, and the so-called leaky gut syndrome, which mainly results from oxidative stress reactions that dam…
View article: H2 partial pressure switches autotrophic pathways in an anaerobic bacterium
H2 partial pressure switches autotrophic pathways in an anaerobic bacterium Open
Most of our knowledge on microbial physiology and biochemistry is based on studies performed under laboratory conditions. For growing hydrogen-oxidizing anaerobic, autotrophic prokaryotes, an H2:CO2 (80:20, v/v) gas m…
View article: Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol
Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol Open
View article: Probiotics, Prebiotics, and Phytogenic Substances for Optimizing Gut Health in Poultry
Probiotics, Prebiotics, and Phytogenic Substances for Optimizing Gut Health in Poultry Open
The gut microbiota has been designated as a hidden metabolic ‘organ’ because of its enormous impact on host metabolism, physiology, nutrition, and immune function. The connection between the intestinal microbiota and their respective host …
View article: H2 partial pressure switches autotrophic pathways in an anaerobic bacterium
H2 partial pressure switches autotrophic pathways in an anaerobic bacterium Open
proteomics.xlsx: Full proteome expression data for Table S6 *.tab files: Initial sequence sets as downloaded from UniProtKB. *_cluster.fa: Sequences clustered to an identity of 95% *_cluster.fa.clstr: Clustering information *_cluster_homo.…
View article: H2 partial pressure switches autotrophic pathways in an anaerobic bacterium
H2 partial pressure switches autotrophic pathways in an anaerobic bacterium Open
proteomics.xlsx: Full proteome expression data for Table S6 *.tab files: Initial sequence sets as downloaded from UniProtKB. *_cluster.fa: Sequences clustered to an identity of 95% *_cluster.fa.clstr: Clustering information *_cluster_homo.…
View article: In vitro interaction network of a synthetic gut bacterial community
In vitro interaction network of a synthetic gut bacterial community Open
A key challenge in microbiome research is to predict the functionality of microbial communities based on community membership and (meta)-genomic data. As central microbiota functions are determined by bacterial community networks, it is im…
View article: The Abiotic Formation of Pyrrole under Volcanic, Hydrothermal Conditions—An Initial Step towards Life’s First Breath?
The Abiotic Formation of Pyrrole under Volcanic, Hydrothermal Conditions—An Initial Step towards Life’s First Breath? Open
Porphyrins, corrins, and tetrapyrroles constitute macrocycles in essential biomolecules such as heme, chlorophyll, cobalamin, and cofactor F430. The chemical synthesis as well as the enzymatic synthesis of these macrocycles starts from pyr…
View article: Metabolic adaption of Legionella pneumophila during intracellular growth in Acanthamoeba castellanii
Metabolic adaption of Legionella pneumophila during intracellular growth in Acanthamoeba castellanii Open
The metabolism of Legionella pneumophila strain Paris was elucidated during different time intervals of growth within its natural host Acanthamoeba castellanii. For this purpose, the amoebae were supplied after bacterial infection (t =0 h)…
View article: Formation of Thiophene under Simulated Volcanic Hydrothermal Conditions on Earth—Implications for Early Life on Extraterrestrial Planets?
Formation of Thiophene under Simulated Volcanic Hydrothermal Conditions on Earth—Implications for Early Life on Extraterrestrial Planets? Open
Thiophene was detected on Mars during the Curiosity mission in 2018. The compound was even suggested as a biomarker due to its possible origin from diagenesis or pyrolysis of biological material. In the laboratory, thiophene can be synthes…
View article: Author Correction: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis
Author Correction: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis Open
View article: Characterization of Sunflower Oil Extracts from the Lichen Usnea barbata
Characterization of Sunflower Oil Extracts from the Lichen Usnea barbata Open
The increasing global emergence of multidrug resistant (MDR) pathogens is categorized as one of the most important health problems. Therefore, the discovery of novel antimicrobials is of the utmost importance. Lichens provide a rich source…
View article: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis
Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis Open