Claudia Kohl
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View article: Country-wide assessment of tick-borne pathogens collected in ticks between 2021 and 2024 in Germany, with a focus on Francisella: A one health pilot study
Country-wide assessment of tick-borne pathogens collected in ticks between 2021 and 2024 in Germany, with a focus on Francisella: A one health pilot study Open
Ticks are important vectors for several pathogens, among which Francisella tularensis subsp. holarctica is the most relevant tularaemia-causing subspecies in Europe. The number of human tularaemia cases in Germany has increased in recent y…
View article: First report of pathogenic<i>Leptospira</i>in Sri Lankan bats: A potential reservoir risk
First report of pathogenic<i>Leptospira</i>in Sri Lankan bats: A potential reservoir risk Open
Background Leptospirosis is a bacterial infection caused by spirochetes of the genus Leptospira . It affects both humans and animals, posing a significant public health threat worldwide. In Sri Lanka, leptospirosis causes annual outbreaks,…
View article: First Report of Nipah virus shed in urine by fruit bats<i>(Pteropus medius)</i>, Sri Lanka
First Report of Nipah virus shed in urine by fruit bats<i>(Pteropus medius)</i>, Sri Lanka Open
Nipah virus is an emerging pathogen with high public health relevance, causing outbreaks in South- and Southeast Asia with high case fatality rates. The natural reservoir host are fruit bats ( Pteropus spp ). In this study, we confirmed th…
View article: Serological methods for the detection of antibodies against monkeypox virus applicable for laboratories with different biosafety levels
Serological methods for the detection of antibodies against monkeypox virus applicable for laboratories with different biosafety levels Open
The monkeypox virus (MPXV) outbreak in 2022 has renewed interest in the detection of antibodies against orthopox viruses (OPXV) and MPXV, as serological methods can aid diagnostics and are key to epidemiological studies. Here three complem…
View article: Serological methods for the detection of antibodies against Monkeypox virus applicable for laboratories with different biosafety levels
Serological methods for the detection of antibodies against Monkeypox virus applicable for laboratories with different biosafety levels Open
The monkeypox virus (MPXV) outbreak in 2022 has renewed interest in the detection of antibodies against orthopox viruses (OPXV) and MPXV, as serological methods can aid diagnostics and are key to epidemiological studies. Here three complem…
View article: Detection and genetic characterization of circoviruses in more than 80 bat species from eight countries on four continents
Detection and genetic characterization of circoviruses in more than 80 bat species from eight countries on four continents Open
Several bat-associated circoviruses and circular rep-encoding single-stranded DNA (CRESS DNA) viruses have been described, but the exact diversity and host species of these viruses are often unknown. Our goal was to describe the diversity …
View article: Vaccine effectiveness against severe COVID-19 during the Omicron wave in Germany: Results from the COViK study
Vaccine effectiveness against severe COVID-19 during the Omicron wave in Germany: Results from the COViK study Open
Purpose COViK - a prospective hospital-based multicenter case-control study in Germany - aims to assess the effectiveness of COVID-19 vaccines against severe disease. Here, we report vaccine effectiveness (VE) against COVID-19-caused hospi…
View article: Possible adaption of the 2022 Monkeypox virus to the human host through gene duplication and loss
Possible adaption of the 2022 Monkeypox virus to the human host through gene duplication and loss Open
Poxviruses are known to evolve slower than RNA viruses, with rearrangements such as gene gain and loss as the main driver for host adaption. In 2022 the world is being challenged by the largest global outbreak so far of Monkeypox virus, an…
View article: Genome sequencing of the Monkeypox virus 2022 outbreak with Amplicon-based Oxford Nanopore MinION sequencing
Genome sequencing of the Monkeypox virus 2022 outbreak with Amplicon-based Oxford Nanopore MinION sequencing Open
We present an amplicon-based assay for MinION Nanopore sequencing of monkeypox virus genomes from clinical specimens, obtaining high-quality results for up to 99 % of the genomes, even for samples with high Ct values of up to 30 which are …
View article: One Health Approach for the sampling of different bat species living in a sympatric colony
One Health Approach for the sampling of different bat species living in a sympatric colony Open
Bats are important contributors to the global ecosystems; at the same time, they are known to be a natural reservoir host for a number of human pathogenic viruses. These and many other unique features make them an interdisciplinary researc…
View article: <i>Comparative virome analysis of individual shedding routes of</i> Miniopterus fuliginosus <i>bats inhabiting the Wavul Galge Cave, Sri Lanka</i>
<i>Comparative virome analysis of individual shedding routes of</i> Miniopterus fuliginosus <i>bats inhabiting the Wavul Galge Cave, Sri Lanka</i> Open
Bats are described as the natural reservoir host for a wide range of viruses. Although an increasing number of bat-associated, potentially human pathogenic viruses were discovered in the past, the full picture of the bat viromes is not exp…
View article: First Complete Cytochrome B Sequences and Molecular Taxonomy of Bat Species from Sri Lanka
First Complete Cytochrome B Sequences and Molecular Taxonomy of Bat Species from Sri Lanka Open
This is the first report on the molecular identification and phylogeny of the Rousettus leschenaultii Desmarest, 1810, Rhinolophus rouxii Temminck, 1835, Hipposideros speoris Schneider, 1800, Hipposideros lankadiva Kelaart, 1850, and Minio…
View article: Effectiveness of vaccines in preventing hospitalization due to COVID-19: A multicenter hospital-based case-control study, Germany, June 2021 to January 2022
Effectiveness of vaccines in preventing hospitalization due to COVID-19: A multicenter hospital-based case-control study, Germany, June 2021 to January 2022 Open
We included 852 patients in a prospectively recruiting multicenter matched case-control study in Germany to assess vaccine effectiveness (VE) in preventing COVID-19-associated hospitalization (Delta-variant dominance). Two-dose VE was 89% …
View article: Paramyxovirus Diversity within One Population of Miniopterus fuliginosus Bats in Sri Lanka
Paramyxovirus Diversity within One Population of Miniopterus fuliginosus Bats in Sri Lanka Open
Bats are known as typical reservoirs for a number of viruses, including viruses of the family Paramyxoviridae. Representatives of the subfamily Orthoparamyxovirinae are distributed worldwide and can cause mild to fatal diseases when infect…
View article: Full Genome of batCoV/MinFul/2018/SriLanka, a Novel Alpha-Coronavirus Detected in Miniopterus fuliginosus, Sri Lanka
Full Genome of batCoV/MinFul/2018/SriLanka, a Novel Alpha-Coronavirus Detected in Miniopterus fuliginosus, Sri Lanka Open
Coronaviruses (CoV) are divided into the genera α-CoVs, β-CoVs, γ-CoVs and δ-CoVs. Of these, α-CoVs and β-CoVs are solely capable of causing infections in humans, resulting in mild to severe respiratory symptoms. Bats have been identified …
View article: Molecular identification of bats from Wavulgalge cave, Wellawaya, Sri Lanka
Molecular identification of bats from Wavulgalge cave, Wellawaya, Sri Lanka Open
This is the first report on the molecular identification and phylogeny of Rousettus leschenaultii, Rhinolophus rouxii, Hipposideros speoris, Hipposideros lankadiva, Miniopterus fuliginosus bat species in Sri Lanka, inferred from mitochondr…
View article: Update on Potentially Zoonotic Viruses of European Bats
Update on Potentially Zoonotic Viruses of European Bats Open
Bats have been increasingly gaining attention as potential reservoir hosts of some of the most virulent viruses known. Numerous review articles summarize bats as potential reservoir hosts of human-pathogenic zoonotic viruses. For European …
View article: Detection of Alpha- and Betacoronaviruses in Miniopterus fuliginosus and Rousettus leschenaultii, two species of Sri Lankan Bats
Detection of Alpha- and Betacoronaviruses in Miniopterus fuliginosus and Rousettus leschenaultii, two species of Sri Lankan Bats Open
Bats are known to be potential reservoirs of numerous human-pathogenic viruses. They have been identified as natural hosts for coronaviruses, causing Severe Acute Respiratory Syndrome (SARS) in humans. Since the emergence of SARS-CoV-2 in …
View article: Infectious KoRV-related retroviruses circulating in Australian bats
Infectious KoRV-related retroviruses circulating in Australian bats Open
Bats are reservoirs of emerging viruses that are highly pathogenic to other mammals, including humans. Despite the diversity and abundance of bat viruses, to date they have not been shown to harbor exogenous retroviruses. Here we report th…
View article: PAIPline: pathogen identification in metagenomic and clinical next generation sequencing samples
PAIPline: pathogen identification in metagenomic and clinical next generation sequencing samples Open
Motivation Next generation sequencing (NGS) has provided researchers with a powerful tool to characterize metagenomic and clinical samples in research and diagnostic settings. NGS allows an open view into samples useful for pathogen detect…
View article: Hervey virus: Study on co-circulation with Henipaviruses in Pteropid bats within their distribution range from Australia to Africa
Hervey virus: Study on co-circulation with Henipaviruses in Pteropid bats within their distribution range from Australia to Africa Open
In 2011, an unusually large number of independent Hendra virus outbreaks were recorded on horse properties in Queensland and New South Wales, Australia. Urine from bat colonies adjacent to the outbreak sites were sampled and screened for H…
View article: Use of RNALater® Preservation for Virome Sequencing in Outbreak Settings
Use of RNALater® Preservation for Virome Sequencing in Outbreak Settings Open
Outbreaks of infectious diseases may occur in animal and human populations; this underlines the need for suitable One Health approaches. During outbreak situations, straightforward identification of etiological agents is indispensable for …
View article: Comparing Viral Metagenomic Extraction Methods
Comparing Viral Metagenomic Extraction Methods Open
A crucial step in the molecular detection of viruses in clinical specimens is the efficient extraction of viral nucleic acids. The total yield of viral nucleic acid from a clinical specimen is dependent on the specimen's volume, the initia…