Cláudia Barbosa Ladeira de Campos
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View article: O papel da Atenção Primária à Saúde (APS) no cuidado pré-concepcional de mulheres com Síndrome dos Ovários Policísticos (SOP)
O papel da Atenção Primária à Saúde (APS) no cuidado pré-concepcional de mulheres com Síndrome dos Ovários Policísticos (SOP) Open
Objetivo: analisar o que há descrito na literatura científica acerca do papel da Atenção Primária à Saúde (APS) no planejamento familiar de mulheres com síndrome do ovário policístico (SOP). Material e método: Trata-se de uma revisão integ…
View article: Ferramentas de educação em saúde aplicada na adesão e permanência do aleitamento materno (AM): uma revisão da literatura
Ferramentas de educação em saúde aplicada na adesão e permanência do aleitamento materno (AM): uma revisão da literatura Open
Objetivo: Analisar o que há descrito na literatura científica, frente às ferramentas de educação em saúde, que são aplicadas, junto às gestantes, parturientes e / ou puérperas para favorecer a adesão e permanência do aleitamento materno (A…
View article: Land-use and land-cover changes and emerging non-tuberculous and tuberculous infectious diseases in humans and animals: a mixed-methods review of research findings from global and spatio-temporal perspectives
Land-use and land-cover changes and emerging non-tuberculous and tuberculous infectious diseases in humans and animals: a mixed-methods review of research findings from global and spatio-temporal perspectives Open
Despite recent interest in land-use and land-cover (LULC) change effects on emerging infectious diseases (EIDs), the debate on global potential health threats remains polarizing. These depend on diverse LULC changes, different types of inf…
View article: Correction to “Mannose-6-Phosphate Isomerase Functional Status Shapes a Rearrangement in the Proteome and Degradome of Mannose-Treated Melanoma Cells”
Correction to “Mannose-6-Phosphate Isomerase Functional Status Shapes a Rearrangement in the Proteome and Degradome of Mannose-Treated Melanoma Cells” Open
View article: Mannose-6-Phosphate Isomerase Functional Status Shapes a Rearrangement in the Proteome and Degradome of Mannose-Treated Melanoma Cells
Mannose-6-Phosphate Isomerase Functional Status Shapes a Rearrangement in the Proteome and Degradome of Mannose-Treated Melanoma Cells Open
Metabolic reprogramming is a ubiquitous feature of transformed cells, comprising one of the hallmarks of cancer and enabling neoplastic cells to adapt to new environments. Accumulated evidence reports on the failure of some neoplastic cell…
View article: O uso de cães de biodetecção na Perícia Criminal
O uso de cães de biodetecção na Perícia Criminal Open
A sensibilidade olfativa dos cães é uma potente ferramenta que vem sendo utilizada há muito tempo pelo homem nas mais diversas tarefas. No campo das ciências forenses, tem se mostrado um recurso igualmente relevante: diversos estudos e exp…
View article: Rhodococcus erythropolis ATCC 4277 behavior against different metals and its potential use in waste biomining
Rhodococcus erythropolis ATCC 4277 behavior against different metals and its potential use in waste biomining Open
Rhodococcus erythropolis bacterium is known for its remarkable resistance characteristics that can be useful in several biotechnological processes, such as bioremediation. However, there is scarce knowledge concerning the behavior of this …
View article: Transcriptional profiling of a fungal granuloma reveals a low metabolic activity of Paracoccidioides brasiliensis yeasts and an actively regulated host immune response
Transcriptional profiling of a fungal granuloma reveals a low metabolic activity of Paracoccidioides brasiliensis yeasts and an actively regulated host immune response Open
Granulomas are important immunological structures in the host defense against the fungus Paracoccidioides brasiliensis , the main etiologic agent of Paracoccidioidomycosis (PCM), a granulomatous systemic mycosis endemic in Latin America. W…
View article: Revealing protonation states and tracking substrate in serine hydroxymethyltransferase with room-temperature X-ray and neutron crystallography
Revealing protonation states and tracking substrate in serine hydroxymethyltransferase with room-temperature X-ray and neutron crystallography Open
Pyridoxal 5’-phosphate (PLP)-dependent enzymes utilize a vitamin B 6 -derived cofactor to perform a myriad of chemical transformations on amino acids and other small molecules. Some PLP-dependent enzymes, such as serine hydroxymethyltransf…
View article: The IV International Symposium on Fungal Stress and the XIII International Fungal Biology Conference
The IV International Symposium on Fungal Stress and the XIII International Fungal Biology Conference Open
View article: Inhibition of the SARS-CoV-2 Main Protease by Isoquercitrin γ-Cyclodextrin Inclusion Complex Formulations: A Biochemical and In Silico Study
Inhibition of the SARS-CoV-2 Main Protease by Isoquercitrin γ-Cyclodextrin Inclusion Complex Formulations: A Biochemical and In Silico Study Open
The main protease (Mpro) of SARS-CoV-2 is a well-established drug target for rational drug design of COVID-19 inhibitors. To address the serious challenge of COVID-19, we have performed biochemical inhibition screens with recombinantly exp…
View article: Scientific novelty beyond the experiment
Scientific novelty beyond the experiment Open
Practical experiments drive important scientific discoveries in biology, but theory‐based research studies also contribute novel—sometimes paradigm‐changing—findings. Here, we appraise the roles of theory‐based approaches focusing on the e…
View article: Biochemical Screening of Potent Zika Virus Protease Inhibitors
Biochemical Screening of Potent Zika Virus Protease Inhibitors Open
As the Zika virus protease is an essential and well‐established target for the development of antiviral agents, we biochemically screened for inhibitors using a purified recombinantly expressed form of this enzyme. As a result, we were abl…
View article: Biochemical screening for SARS-CoV-2 main protease inhibitors
Biochemical screening for SARS-CoV-2 main protease inhibitors Open
The Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) pandemic represents a global challenge. SARS-CoV-2's ability to replicate in host cells relies on the action of its non-structural proteins, like its main protease (Mpro). T…
View article: A biochemical network modeling of a whole-cell
A biochemical network modeling of a whole-cell Open
All cellular processes can be ultimately understood in terms of respective fundamental biochemical interactions between molecules, which can be modeled as networks. Very often, these molecules are shared by more than one process, therefore…
View article: Forecast UTI: aplicativo para previsão de leitos de unidades de terapia intensiva no contexto da pandemia de covid-19
Forecast UTI: aplicativo para previsão de leitos de unidades de terapia intensiva no contexto da pandemia de covid-19 Open
Frente à necessidade de gerenciamento e previsão do número de leitos de unidades de terapia intensiva (UTI) para pacientes graves de covid-19, foi desenvolvido o Forecast UTI, um aplicativo de livre acesso e que permite o monitoramento de …
View article: The Third International Symposium on Fungal Stress – ISFUS
The Third International Symposium on Fungal Stress – ISFUS Open
View article: Ferramenta para estimar o número de leitos de UTI necessário por dia e gestão de equipamentos durante a epidemia de COVID-19 em diversos cenários
Ferramenta para estimar o número de leitos de UTI necessário por dia e gestão de equipamentos durante a epidemia de COVID-19 em diversos cenários Open
View article: Forecast UTI: aplicativo para previsão de leitos de unidades de terapia intensiva no contexto da pandemia de COVID-19
Forecast UTI: aplicativo para previsão de leitos de unidades de terapia intensiva no contexto da pandemia de COVID-19 Open
Resumo Frente à necessidade de gerenciamento e previsão do número de leitos de unidades de terapia intensiva (UTIs) para pacientes graves de COVID-19, foi desenvolvido o Forecast UTI, um aplicativo de livre acesso, que permite o monitorame…
View article: Autophagy in Paracoccidioides brasiliensis under normal mycelia to yeast transition and under selective nutrient deprivation
Autophagy in Paracoccidioides brasiliensis under normal mycelia to yeast transition and under selective nutrient deprivation Open
Paracoccidioides spp. is a thermally dimorphic fungus endemic to Latin America and the etiological agent of paracoccidioidomycosis (PCM), a granulomatous disease acquired through fungal propagule inhalation by its mammalian host. The infec…
View article: Structural basis for dimer formation of the <scp>CRISPR</scp>‐associated protein Csm2 of <i>Thermotoga maritima</i>
Structural basis for dimer formation of the <span>CRISPR</span>‐associated protein Csm2 of <i>Thermotoga maritima</i> Open
The clusters of regularly interspaced short palindromic repeats ( CRISPR ) and the Cas ( CRISPR ‐associated) proteins form an adaptive immune system in bacteria and archaea that evolved as an RNA ‐guided interference mechanism to target an…
View article: Purification, crystallization, crystallographic analysis and phasing of the CRISPR-associated protein Csm2 from <i>Thermotoga maritima</i>
Purification, crystallization, crystallographic analysis and phasing of the CRISPR-associated protein Csm2 from <i>Thermotoga maritima</i> Open
The clusters of regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated proteins (Cas) system consists of an intriguing machinery of proteins that confer bacteria and archaea with immunity against phages and plasmids via…