Claudia M. Denkinger
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View article: Sputum scarcity among adolescents and adults with presumptive tuberculosis: a systematic review and meta-analysis
Sputum scarcity among adolescents and adults with presumptive tuberculosis: a systematic review and meta-analysis Open
Summary Background The diagnosis of tuberculosis (TB) typically relies on being able to produce a sputum sample for microbiological testing. However, sputum scarcity, the inability to self-expectorate an adequate sputum sample for TB testi…
View article: Sputum scarcity and respiratory sample availability among children with presumptive tuberculosis in high burden countries: a systematic review and meta-analysis
Sputum scarcity and respiratory sample availability among children with presumptive tuberculosis in high burden countries: a systematic review and meta-analysis Open
Summary Background Tuberculosis (TB) diagnosis typically relies on testing sputum samples, but children often cannot produce sputum. Our review investigated the collection of self-expectorated and induced sputum, and alternative methods of…
View article: Diagnostic accuracy of swab-based molecular tests for tuberculosis using near-point-of-care platforms: a multi-country evaluation
Diagnostic accuracy of swab-based molecular tests for tuberculosis using near-point-of-care platforms: a multi-country evaluation Open
National Institutes of Health (U01AI152087), Gates Foundation, and Global Health Labs.
View article: Importance of confirmatory test characteristics in optimizing community-based screening for tuberculosis: an epidemiological modeling analysis
Importance of confirmatory test characteristics in optimizing community-based screening for tuberculosis: an epidemiological modeling analysis Open
View article: Ribosomal protection as a linezolid resistance mechanism in <i>Mycobacterium abscessus</i>
Ribosomal protection as a linezolid resistance mechanism in <i>Mycobacterium abscessus</i> Open
Mycobacterium abscessus has emerged as a significant pulmonary pathogen characterized by its resistance to most first-line antimycobacterial drugs. Recent investigations have highlighted the clinical efficacy of including the oxazolidinone…
View article: Benefit incidence analysis of decentralized Truenat MTB Plus and MTB-RIF Dx compared to hub-and-spoke Xpert MTB/RIF in Mozambique and Tanzania (TB-CAPT CORE trial)
Benefit incidence analysis of decentralized Truenat MTB Plus and MTB-RIF Dx compared to hub-and-spoke Xpert MTB/RIF in Mozambique and Tanzania (TB-CAPT CORE trial) Open
Introduction Tuberculosis (TB) is a major public health threat worldwide and about one-third of cases go undiagnosed or unreported, leading to continued transmission of the disease. While point-of-care diagnostics are crucial to improve ca…
View article: COVID-19 convalescent plasma for B-cell depleted patients: a systematic review and individual patient data meta-analysis
COVID-19 convalescent plasma for B-cell depleted patients: a systematic review and individual patient data meta-analysis Open
COVID-19 convalescent plasma (CCP) obtained from recently recovered people is safe and effective against SARS-CoV-2. Currently available CCP is a “hybrid” product with antibodies from individuals who had both infection and vaccination (vac…
View article: A cost-effectiveness analysis of novel stool processing methods for diagnosis of tuberculosis in children under 5 years of age in Uganda
A cost-effectiveness analysis of novel stool processing methods for diagnosis of tuberculosis in children under 5 years of age in Uganda Open
View article: Whom tuberculosis tests detect and why it matters: implications for diagnostic algorithms
Whom tuberculosis tests detect and why it matters: implications for diagnostic algorithms Open
Tuberculosis encompasses a spectrum of characteristics-including bacillary burden, clinical severity, and access to care-that are relevant to clinical and epidemiological outcomes and the performance of diagnostic assays. The value of diag…
View article: Implementing the Molbio Truenat platform and tuberculosis assays versus standard of care at primary care clinics for the detection and treatment of tuberculosis in Mozambique and Tanzania (TB-CAPT CORE): a cluster-randomised trial
Implementing the Molbio Truenat platform and tuberculosis assays versus standard of care at primary care clinics for the detection and treatment of tuberculosis in Mozambique and Tanzania (TB-CAPT CORE): a cluster-randomised trial Open
View article: Preferences for tongue swab-based versus sputum-based testing in the context of TB care: a best-worst scaling exercise in Vietnam and Zambia
Preferences for tongue swab-based versus sputum-based testing in the context of TB care: a best-worst scaling exercise in Vietnam and Zambia Open
Background The development of non-sputum-based tests is an urgent priority to increase access to tuberculosis (TB) diagnostic testing. Understanding preferences of people undergoing testing is critical for designing tests and strategies al…
View article: Lung and abdominal ultrasound accuracy for tuberculosis: An Indian prospective cohort study
Lung and abdominal ultrasound accuracy for tuberculosis: An Indian prospective cohort study Open
Background Tuberculosis (TB) diagnosis remains a challenge, particularly in low-resource settings. Point-of-care ultrasound (POCUS) has shown promise, but most studies focus on HIV-infected populations. In the case of TB, data on lung ultr…
View article: Preferences for tuberculosis diagnostic test features among people tested for tuberculosis: a multicountry discrete choice experiment
Preferences for tuberculosis diagnostic test features among people tested for tuberculosis: a multicountry discrete choice experiment Open
View article: AveloMask, a novel breath aerosol collection kit for airborne <i>Mycobacterium tuberculosis</i> : a proof-of-principle assessment
AveloMask, a novel breath aerosol collection kit for airborne <i>Mycobacterium tuberculosis</i> : a proof-of-principle assessment Open
Tuberculosis (TB) remains the world’s deadliest infectious disease, with many active cases missed due to challenges in sputum collection. Exhaled breath aerosols (XBA), a major route of Mycobacterium tuberculosis (MTB) transmission, offer …
View article: Cost and cost-effectiveness of swab-based molecular testing for tuberculosis in the Philippines, Uganda, Vietnam, and Zambia
Cost and cost-effectiveness of swab-based molecular testing for tuberculosis in the Philippines, Uganda, Vietnam, and Zambia Open
Background Tongue swabs (TS) offer a promising alternative to sputum-based molecular testing for tuberculosis. As part of the Tongue Swab Yield (TSwaY) study, we assessed the cost and cost-effectiveness of integrating TS-based testing usin…
View article: Current practices for assessing usability of novel point-of-care diagnostics for infectious diseases: a scoping review protocol
Current practices for assessing usability of novel point-of-care diagnostics for infectious diseases: a scoping review protocol Open
Introduction Novel diagnostics, particularly point-of-care (POC) tests, play a crucial role in the early detection and management of infectious diseases, especially in resource-limited settings. Ensuring test performance and quality while …
View article: Performance of whole blood interferon-γ release assays in SARS-CoV-2 and tuberculosis is age dependent
Performance of whole blood interferon-γ release assays in SARS-CoV-2 and tuberculosis is age dependent Open
Introduction A lot of research has been done, mainly on tuberculosis (TB), on the extent to which cellular immune protection as measured by interferon-γ release assays (IGRA) is age-dependent. In a previous study we showed that following a…
View article: Implementation of Point-of-Care PCR-testing for the diagnosis of respiratory infections in vulnerable patient populations
Implementation of Point-of-Care PCR-testing for the diagnosis of respiratory infections in vulnerable patient populations Open
Background Point-of-Care (POC) PCR-testing provides accurate, and timely results in diagnosing respiratory viral infections. Despite these benefits, stakeholder perceptions and its potential for improving health outcomes remain insufficien…
View article: Informing People-Centered Target Product Profiles for TB Diagnostics: A Multi-Country Qualitative Study
Informing People-Centered Target Product Profiles for TB Diagnostics: A Multi-Country Qualitative Study Open
Background Timely and accurate tuberculosis (TB) diagnosis remains a key challenge in high-burden settings. The World Health Organization (WHO) has developed Target Product Profiles (TPPs) to guide diagnostic development, which have largel…
View article: Performance and feasibility of self-microsampling of capillary blood and saliva for serological testing of SARS-CoV-2
Performance and feasibility of self-microsampling of capillary blood and saliva for serological testing of SARS-CoV-2 Open
Background Serology is a valuable tool to estimate infections, case-fatality rates, and immunity. However, venipuncture and clinical infrastructure hinder scalability. This study evaluated the performance, feasibility and user experience o…
View article: Tongue Swab Xpert MTB/RIF Ultra Testing for Tuberculosis Using a Revised Consensus Protocol: A multi-country diagnostic accuracy study
Tongue Swab Xpert MTB/RIF Ultra Testing for Tuberculosis Using a Revised Consensus Protocol: A multi-country diagnostic accuracy study Open
Background Tongue swabs are a promising specimen for tuberculosis (TB) diagnosis. In a previous study using a consensus protocol, tongue swabs tested with Xpert MTB/RIF Ultra (Xpert Ultra, Cepheid, USA) outperformed sputum smear microscopy…
View article: Preferences for Tongue Swab versus Sputum Collection for Tuberculosis Testing: A Multi-Country Survey
Preferences for Tongue Swab versus Sputum Collection for Tuberculosis Testing: A Multi-Country Survey Open
Background: Sputum collection for tuberculosis (TB) diagnosis poses challenges for children, people living with HIV, and those who struggle with sputum production. Tongue swab-based molecular testing offers a promising non-invasive alterna…
View article: Diagnostic yield of tongue swab- compared to sputum-based molecular testing for tuberculosis in four high-burden countries
Diagnostic yield of tongue swab- compared to sputum-based molecular testing for tuberculosis in four high-burden countries Open
Background Tongue swabs are a promising alternative specimen for tuberculosis (TB) diagnosis, with high specificity (>98%) but lower sensitivity than sputum-based molecular tests. We investigated whether increased sample availability could…
View article: “That is why I trust”: A qualitative study on acceptability and feasibility of novel tongue swab diagnostics to assess people presenting with tuberculosis symptoms in Viet Nam and Zambia
“That is why I trust”: A qualitative study on acceptability and feasibility of novel tongue swab diagnostics to assess people presenting with tuberculosis symptoms in Viet Nam and Zambia Open
Millions of tuberculosis (TB) cases are estimated to be undiagnosed and unreported annually. Sputum has been the primary approach for diagnostic testing but tongue swabs are being investigated as an alternative to expand testing. To unders…
View article: Comparing the accuracy of computer-aided detection (CAD) software and radiologists from multiple countries for tuberculosis detection in chest X-Rays
Comparing the accuracy of computer-aided detection (CAD) software and radiologists from multiple countries for tuberculosis detection in chest X-Rays Open
Nearly a third of TB cases go undetected annually. WHO recommends computer-aided detection (CAD) to enhance TB screening, with studies showing comparable performance to local radiologists. Using 774 chest X-rays from the South African Nati…
View article: Responsive population-based cohorts as platforms for characterising pathogen- and population-level infection dynamics for epidemic prevention, preparedness and response
Responsive population-based cohorts as platforms for characterising pathogen- and population-level infection dynamics for epidemic prevention, preparedness and response Open
Establishing population-based cohorts is indispensable for effective epidemic prevention, preparedness and response. Existing passive surveillance systems face limitations in their capacity to promptly provide representative data for estim…
View article: Integrated treatment-decision algorithms for childhood TB: modelling diagnostic performance and costs
Integrated treatment-decision algorithms for childhood TB: modelling diagnostic performance and costs Open
Background To improve childhood tuberculosis (TB) diagnosis, treatment-decision algorithms (TDAs) with and without chest X-ray (CXR) were developed for children under age 10. We aimed to model diagnostic performance and costs of implementi…
View article: Prototyping an internet-of-things-based bioacoustics system to support research and surveillance of avian-associated infectious diseases
Prototyping an internet-of-things-based bioacoustics system to support research and surveillance of avian-associated infectious diseases Open
Zoonotic infectious diseases and cross-species pathogen spillover are driven by biodiversity and spatio-temporal ecological interactions. Generating high-resolution data to approximate the presence and absence of animals and their mobility…
View article: Decentralized TB diagnostic testing with Truenat MTB Plus and MTB-RIF Dx vs. hub-and-spoke GeneXpert MTB/RIF Ultra in Mozambique and Tanzania: a cost and cost-effectiveness analysis
Decentralized TB diagnostic testing with Truenat MTB Plus and MTB-RIF Dx vs. hub-and-spoke GeneXpert MTB/RIF Ultra in Mozambique and Tanzania: a cost and cost-effectiveness analysis Open
In low-and middle-income countries, missed or delayed tuberculosis (TB) diagnoses contribute to avoidable morbidity, mortality, and transmission. Decentralized testing platforms, such as the Molbio Truenat, may offer solutions by providing…
View article: Convalescent plasma treatment of B-cell depleted patients with COVID-19: systematic review and individual participant data meta-analysis
Convalescent plasma treatment of B-cell depleted patients with COVID-19: systematic review and individual participant data meta-analysis Open
Background COVID-19 convalescent plasma (CCP) is obtained from people recently recovered from COVID-19 and contains viral-neutralizing antibodies. Because such treatment is safe and effective against SARS-CoV-2, the US Food and Drug Admini…