Claudia M. Hillenbrand
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View article: Comparing Whole-Body Diffusion-weighted MRI to Conventional Imaging: Staging Pediatric Bone and Soft-Tissue Sarcomas
Comparing Whole-Body Diffusion-weighted MRI to Conventional Imaging: Staging Pediatric Bone and Soft-Tissue Sarcomas Open
Whole-body diffusion-weighted MRI demonstrated agreement with conventional imaging and higher lesion sensitivity but lower specificity than PET/CT in staging pediatric bone and soft-tissue sarcomas.
View article: Repeated Cranial and Large‐Vessel Positron Emission Tomography/Computed Tomography Scans and the Association With Structural Aortic Disease in Giant Cell Arteritis: A Five‐Year Observational Study
Repeated Cranial and Large‐Vessel Positron Emission Tomography/Computed Tomography Scans and the Association With Structural Aortic Disease in Giant Cell Arteritis: A Five‐Year Observational Study Open
Objective Giant cell arteritis (GCA) is characterized by cranial ischemia at diagnosis and late aortic structural disease. Repeated combined cranial and large‐vessel fluoro‐2‐deoxyglucose (FDG) positron emission tomography (PET)/computed t…
View article: P835: Practical implementation of ACOG and ACMG carrier screening guidelines at a single academic medical center
P835: Practical implementation of ACOG and ACMG carrier screening guidelines at a single academic medical center Open
View article: The protocol for an observational Australian cohort study of CADASIL: The AusCADASIL study
The protocol for an observational Australian cohort study of CADASIL: The AusCADASIL study Open
View article: Quantification of Liver Iron Overload with MRI: Review and Guidelines from the ESGAR and SAR
Quantification of Liver Iron Overload with MRI: Review and Guidelines from the ESGAR and SAR Open
Accumulation of excess iron in the body, or systemic iron overload, results from a variety of causes. The concentration of iron in the liver is linearly related to the total body iron stores and, for this reason, quantification of liver ir…
View article: Assessment of Fat Fractions in the Tongue, Soft Palate, Pharyngeal Wall, and Parapharyngeal Fat Pad by the GOOSE and DIXON Methods
Assessment of Fat Fractions in the Tongue, Soft Palate, Pharyngeal Wall, and Parapharyngeal Fat Pad by the GOOSE and DIXON Methods Open
Objective The 2-point DIXON method is widely used to assess fat fractions (FFs) in magnetic resonance images (MRIs) of the tongue, pharyngeal wall, and surrounding tissues in patients with obstructive sleep apnea (OSA). However, the method…
View article: Imaging Modalities for Early Detection of Pancreatic Cancer: Current State and Future Research Opportunities
Imaging Modalities for Early Detection of Pancreatic Cancer: Current State and Future Research Opportunities Open
Pancreatic cancer, one of the most lethal malignancies, is increasing in incidence. While survival rates for many cancers have improved dramatically over the last 20 years, people with pancreatic cancer have persistently poor outcomes. Pot…
View article: Free-breathing radial magnetic resonance elastography of the liver in children at 3 T: a pilot study
Free-breathing radial magnetic resonance elastography of the liver in children at 3 T: a pilot study Open
Background Magnetic resonance (MR) elastography of the liver measures hepatic stiffness, which correlates with the histopathological staging of liver fibrosis. Conventional Cartesian gradient-echo (GRE) MR elastography requires breath-hold…
View article: Hepatic Iron Quantification Using a <scp>Free‐Breathing 3D</scp> Radial Gradient Echo Technique and Validation With a <scp>2D</scp> Biopsy‐Calibrated <scp>R<sub>2</sub></scp><sup>*</sup> Relaxometry Method
Hepatic Iron Quantification Using a <span>Free‐Breathing 3D</span> Radial Gradient Echo Technique and Validation With a <span>2D</span> Biopsy‐Calibrated <span>R<sub>2</sub></span><sup>*</sup> Relaxometry Method Open
Background Hepatic iron content (HIC) is an important parameter for the management of iron overload. Non‐invasive HIC assessment is often performed using biopsy‐calibrated two‐dimensional breath‐hold Cartesian gradient echo (2D BH GRE) R 2…
View article: Quantitative Susceptibility Mapping Using a Multispectral Autoregressive Moving Average Model to Assess Hepatic Iron Overload
Quantitative Susceptibility Mapping Using a Multispectral Autoregressive Moving Average Model to Assess Hepatic Iron Overload Open
Background R2*‐MRI is clinically used to noninvasively assess hepatic iron content (HIC) to guide potential iron chelation therapy. However, coexisting pathologies, such as fibrosis and steatosis, affect R2* measurements and may thus confo…
View article: Cerebral microbleeds in adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiation
Cerebral microbleeds in adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiation Open
View article: GSTM1 and Liver Iron Content in Children with Sickle Cell Anemia and Iron Overload
GSTM1 and Liver Iron Content in Children with Sickle Cell Anemia and Iron Overload Open
Chronic blood transfusions in patients with sickle cell anemia (SCA) cause iron overload, which occurs with a degree of interpatient variability in serum ferritin and liver iron content (LIC). Reasons for this variability are unclear and m…
View article: PF740 CEREBRAL BLOOD FLOW IN ADOLESCENTS WITH SICKLE CELL ANEMIA RECEIVING VOXELOTOR
PF740 CEREBRAL BLOOD FLOW IN ADOLESCENTS WITH SICKLE CELL ANEMIA RECEIVING VOXELOTOR Open
Background: Oxygenated sickle hemoglobin (HbS) does not polymerize; therefore, increasing oxygen affinity to HbS is a therapeutic strategy for sickle cell anemia (SCA; HbSS and HbSβ 0 thalassemia), and voxelotor (GBT440) is a first‐in‐clas…
View article: Autoregressive moving average modeling for hepatic iron quantification in the presence of fat
Autoregressive moving average modeling for hepatic iron quantification in the presence of fat Open
Background Measuring hepatic R2* by fitting a monoexponential model to the signal decay of a multigradient‐echo (mGRE) sequence noninvasively determines hepatic iron content (HIC). Concurrent hepatic steatosis introduces signal oscillation…
View article: Ultrashort echo time imaging for quantification of hepatic iron overload: Comparison of acquisition and fitting methods via simulations, phantoms, and in vivo data
Ultrashort echo time imaging for quantification of hepatic iron overload: Comparison of acquisition and fitting methods via simulations, phantoms, and in vivo data Open
Background Current R2*‐MRI techniques for measuring hepatic iron content (HIC) use various acquisition types and fitting models. Purpose To evaluate the accuracy and precision of R2*‐HIC acquisition and fitting methods. Study Type Signal s…
View article: Erratum to: Fast quantitative parameter maps without fitting: Integration yields accurate mono‐exponential signal decay rates (Magn Reson Med 2018;79:2978–2985)
Erratum to: Fast quantitative parameter maps without fitting: Integration yields accurate mono‐exponential signal decay rates (Magn Reson Med 2018;79:2978–2985) Open
View article: Corporate Tax: What Do Stakeholders Expect?
Corporate Tax: What Do Stakeholders Expect? Open
Motivated by the ongoing controversy surrounding corporate tax, this article presents a study that explores stakeholder expectations of corporate tax in the context of UK business. We conduct a qualitative analysis of in-depth interviews w…
View article: Fast quantitative parameter maps without fitting: Integration yields accurate mono‐exponential signal decay rates
Fast quantitative parameter maps without fitting: Integration yields accurate mono‐exponential signal decay rates Open
Purpose To develop a computationally fast and accurate algorithm for mono‐exponential signal modelling and validate the new technique in the context of mapping for iron overload assessment. Methods An algorithm is introduced that directly …
View article: Diffusion Weighted Imaging Apparent Diffusion Coefficient Evolution in Childhood RMS Suggests a Possible Biologic Target Volume for Radiation Therapy Planning
Diffusion Weighted Imaging Apparent Diffusion Coefficient Evolution in Childhood RMS Suggests a Possible Biologic Target Volume for Radiation Therapy Planning Open
View article: Quantitative ultrashort echo time imaging for assessment of massive iron overload at 1.5 and 3 Tesla
Quantitative ultrashort echo time imaging for assessment of massive iron overload at 1.5 and 3 Tesla Open
Purpose Hepatic iron content (HIC) quantification via transverse relaxation rate (R2*)‐MRI using multi‐gradient echo (mGRE) imaging is compromised toward high HIC or at higher fields due to the rapid signal decay. Our study aims at present…
View article: Removal of Arterial Vessel Contributions in Susceptibility-Weighted Images for Quantification of Normalized Visible Venous Volume in Children with Sickle Cell Disease
Removal of Arterial Vessel Contributions in Susceptibility-Weighted Images for Quantification of Normalized Visible Venous Volume in Children with Sickle Cell Disease Open
Purpose . To evaluate a new postprocessing framework that eliminates arterial vessel signal contributions in the quantification of normalized visible venous volume (NVVV, a ratio between venous and brain volume) in susceptibility-weighted …
View article: Can multi-slice or navigator-gated R2* MRI replace single-slice breath-hold acquisition for hepatic iron quantification?
Can multi-slice or navigator-gated R2* MRI replace single-slice breath-hold acquisition for hepatic iron quantification? Open
View article: Measurement of glomerular filtration rate by dynamic contrast-enhanced magnetic resonance imaging using a subject-specific two-compartment model
Measurement of glomerular filtration rate by dynamic contrast-enhanced magnetic resonance imaging using a subject-specific two-compartment model Open
Measuring glomerular filtration rate (GFR) by dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) as part of standard of care clinicalMRIexams (e.g., in pediatric solid tumor patients) has the potential to reduce diagnostic bu…
View article: Does fat suppression via chemically selective saturation affect R2*-MRI for transfusional iron overload assessment? A clinical evaluation at 1.5T and 3T
Does fat suppression via chemically selective saturation affect R2*-MRI for transfusional iron overload assessment? A clinical evaluation at 1.5T and 3T Open
The CHESS-induced R2* bias at 1.5T needs to be considered when applying R2*-LIC biopsy calibrations for clinical LIC assessment, which were established without FS at 1.5T. The proposed model corrects the R2* bias and could therefore improv…