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View article: Structure-Function Insights into the Dual Role in Nucleobase and Nicotinamide Metabolism and a Possible Use in Cancer Gene Therapy of the URH1p Riboside Hydrolase
Structure-Function Insights into the Dual Role in Nucleobase and Nicotinamide Metabolism and a Possible Use in Cancer Gene Therapy of the URH1p Riboside Hydrolase Open
The URH1p enzyme from the yeast Saccharomyces cerevisiae has gained significant interest due to its role in nitrogenous base metabolism, particularly involving uracil and nicotinamide salvage. Indeed, URH1p was initially classified as a nu…
View article: Association of IgG4-Related Disease with Human Inborn Errors of Immunity
Association of IgG4-Related Disease with Human Inborn Errors of Immunity Open
View article: Correction: Time- and cost-effective production of untagged recombinant MVA by flow virometry and direct virus sorting
Correction: Time- and cost-effective production of untagged recombinant MVA by flow virometry and direct virus sorting Open
View article: Time- and cost-effective production of untagged recombinant MVA by flow virometry and direct virus sorting
Time- and cost-effective production of untagged recombinant MVA by flow virometry and direct virus sorting Open
View article: Immunomodulatory Effects of Endoscopic Ultrasound-Guided Thermal Ablation in Patients with Pancreatic Ductal Adenocarcinoma
Immunomodulatory Effects of Endoscopic Ultrasound-Guided Thermal Ablation in Patients with Pancreatic Ductal Adenocarcinoma Open
Immunological consequences of endoscopic ultrasound (EUS)-local thermal ablation (LTA) for pancreatic ductal adenocarcinoma (PDAC) have not been extensively assessed. We aimed to explore EUS-LTA effects on the systemic immune response in P…
View article: Time- and Cost-effective Production of Untagged Recombinant Mva by Flow Virometry and Direct Virus Sorting
Time- and Cost-effective Production of Untagged Recombinant Mva by Flow Virometry and Direct Virus Sorting Open
Background Recombinant MVAs (rMVAs) are widely used both in basic and clinical research. Our previously developed Red-to-Green Gene Swapping Method (RGGSM), a cytometry-based Cell-Sorting protocol, revolves around the transient expression …
View article: POS0352 GENETIC DETERMINANTS OF RESPONSE TO ABATACEPT IN PATIENTS WITH IGG4-RELATED DISEASE
POS0352 GENETIC DETERMINANTS OF RESPONSE TO ABATACEPT IN PATIENTS WITH IGG4-RELATED DISEASE Open
View article: Author Correction: Direct and high throughput (HT) interactions on the ribosomal surface by iRIA
Author Correction: Direct and high throughput (HT) interactions on the ribosomal surface by iRIA Open
View article: A Novel RGD-4C-Saporin Conjugate Inhibits Tumor Growth in Mouse Models of Bladder Cancer
A Novel RGD-4C-Saporin Conjugate Inhibits Tumor Growth in Mouse Models of Bladder Cancer Open
Although toxin may have some advantages compared to chemotherapeutic drugs in cancer therapy, e.g. a potent cytotoxic activity and a reduced risk of resistance, their successful application in the treatments to solid tumors still remains t…
View article: B-Lymphocytes in the Pathophysiology of Pancreatic Adenocarcinoma
B-Lymphocytes in the Pathophysiology of Pancreatic Adenocarcinoma Open
Pancreatic adenocarcinoma is highly infiltrated by B lymphocytes but the relevance of these immune cells in tumor development has been surprisingly overlooked until recently. Based on available evidence from other solid tumors, interaction…
View article: Higher-order immunoglobulin repertoire restrictions in CLL: the illustrative case of stereotyped subsets 2 and 169
Higher-order immunoglobulin repertoire restrictions in CLL: the illustrative case of stereotyped subsets 2 and 169 Open
Chronic lymphocytic leukemia (CLL) major stereotyped subset 2 (IGHV3-21/IGLV3-21, ∼2.5% of all cases of CLL) is an aggressive disease variant, irrespective of the somatic hypermutation (SHM) status of the clonotypic IGHV gene. Minor stereo…
View article: The anti-tumoral potential of the saporin-based uPAR-targeting chimera ATF-SAP
The anti-tumoral potential of the saporin-based uPAR-targeting chimera ATF-SAP Open
View article: Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits
Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits Open
Eukaryotic initiation factor 6 (eIF6) is necessary for the nucleolar biogenesis of 60S ribosomes. However, most of eIF6 resides in the cytoplasm, where it acts as an initiation factor. eIF6 is necessary for maximal protein synthesis downst…
View article: B lymphocytes contribute to stromal reaction in pancreatic ductal adenocarcinoma
B lymphocytes contribute to stromal reaction in pancreatic ductal adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent stromal reaction that has been variably implicated in both tumor growth and tumor suppression. B-lymphocytes have been recently implicated in PDAC progression but thei…
View article: The ERC1 scaffold protein implicated in cell motility drives the assembly of a liquid phase
The ERC1 scaffold protein implicated in cell motility drives the assembly of a liquid phase Open
Several cellular processes depend on networks of proteins assembled at specific sites near the plasma membrane. Scaffold proteins assemble these networks by recruiting relevant molecules. The scaffold protein ERC1/ELKS and its partners pro…
View article: Ligand-induced perturbation of the HIF-2α:ARNT dimer dynamics
Ligand-induced perturbation of the HIF-2α:ARNT dimer dynamics Open
Hypoxia inducible factors (HIFs) are transcription factors belonging to the basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) protein family with a role in sensing oxygen levels in the cell. Under hypoxia, the HIF-α degradation pathway is blo…
View article: Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia Open
Cell-autonomous B-cell receptor (BcR)-mediated signalling is a hallmark feature of the neoplastic B lymphocytes in chronic lymphocytic leukaemia (CLL). Here we elucidate the structural basis of autonomous activation of CLL B cells, showing…
View article: Distinct Homotypic B-Cell Receptor Interactions Shape The Outcome Of Chronic Lymphocytic Leukemia
Distinct Homotypic B-Cell Receptor Interactions Shape The Outcome Of Chronic Lymphocytic Leukemia Open
Distinct Homotypic B-Cell Receptor Interactions Shape The Outcome Of Chronic Lymphocytic Leukemia
View article: Direct and high throughput (HT) interactions on the ribosomal surface by iRIA
Direct and high throughput (HT) interactions on the ribosomal surface by iRIA Open