Claudia Racca
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View article: The correct connectivity of the DG-CA3 circuits involved in declarative memory processes depends on Vangl2-dependent planar cell polarity signaling
The correct connectivity of the DG-CA3 circuits involved in declarative memory processes depends on Vangl2-dependent planar cell polarity signaling Open
In the hippocampus, dentate gyrus granule cells connect to CA3 pyramidal cells via their axons, the mossy fibers (Mf). The synaptic terminals of Mfs (Mf boutons, MfBs) form large and complex synapses with thorny excrescences (TE) on the pr…
View article: The correct temporal connectivity of the DG-CA3 circuits involved in declarative memory processes depends on Vangl2-dependent planar cell polarity signaling
The correct temporal connectivity of the DG-CA3 circuits involved in declarative memory processes depends on Vangl2-dependent planar cell polarity signaling Open
Summary In the hippocampus, dentate gyrus granule cells connect to CA3 pyramidal cells via their axons, the mossy fibers (Mf). The synaptic terminals of Mfs (Mf boutons, MfBs) form large and complex synapses with thorny excrescences (TE) o…
View article: PV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model
PV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model Open
Parvalbumin expressing interneurons are considered to play an important role in regulating cortical activity. We were surprised, therefore, to find that knocking down the transcriptional coactivator, PGC-1α, specifically in this class of i…
View article: Ultrastructural readout of <i>in vivo</i> synaptic activity for functional connectomics
Ultrastructural readout of <i>in vivo</i> synaptic activity for functional connectomics Open
Large-volume ultrastructural mapping approaches yield detailed circuit wiring diagrams but lack an integrated synaptic activity readout which is essential for functional interpretation of the connectome. Here we resolve this limitation by …
View article: PV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model
PV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model Open
The transcriptional coactivator, PGC-1α (peroxisome proliferator activated receptor gamma coactivator 1α), plays a key role coordinating energy requirement within cells. Its importance is reflected in the growing number of psychiatric and …
View article: Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion
Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion Open
View article: Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition
Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition Open
NMDA receptor (NMDAR) subunit composition plays a pivotal role in synaptic plasticity at excitatory synapses. Still, the mechanisms responsible for the synaptic retention of NMDARs following induction of plasticity need to be fully elucida…
View article: Pyramidal cell activity levels affect the polarity of activity-induced gene transcription changes in interneurons
Pyramidal cell activity levels affect the polarity of activity-induced gene transcription changes in interneurons Open
Changes in gene expression are an important mechanism by which activity levels are regulated in the nervous system. It is not known, however, how network activity influences gene expression in interneurons; since they themselves provide ne…
View article: Graphical user interface for simultaneous profiling of activity patterns in multiple neuronal subclasses
Graphical user interface for simultaneous profiling of activity patterns in multiple neuronal subclasses Open
View article: Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias
Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias Open
N-methyl-d-aspartate receptor (NMDAR) subunit composition strictly commands receptor function and pharmacological responses. Changes in NMDAR subunit composition have been documented in brain disorders such as Parkinson's disease (PD) and …
View article: Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse
Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse Open
Planar cell polarity (PCP) signaling is well known to play a critical role during prenatal brain development; whether it plays specific roles at postnatal stages remains rather unknown. Here, we investigated the role of a key PCP-associate…
View article: Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex
Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex Open
View article: The Contribution of Raised Intraneuronal Chloride to Epileptic Network Activity
The Contribution of Raised Intraneuronal Chloride to Epileptic Network Activity Open
Altered inhibitory function is an important facet of epileptic pathology. A key concept is that GABAergic activity can become excitatory if intraneuronal chloride rises. However, it has proved difficult to separate the role of raised chlor…