Claudia Tregnago
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View article: Leukemic Cells Hijack Stromal Bioelectricity to Reprogram the Bone Marrow Niche via CaV1.2‐Dependent Mechanisms
Leukemic Cells Hijack Stromal Bioelectricity to Reprogram the Bone Marrow Niche via CaV1.2‐Dependent Mechanisms Open
Mesenchymal stromal cells (MSCs) are key components of the tumor microenvironment (TME), influencing leukemia progression through poorly understood mechanisms. Here, the bioelectrical properties of MSCs derived from pediatric acute myeloid…
View article: Prognostic Value of Molecular Genetic Measurable Residual Disease ( <scp>MRD</scp> ) Monitoring in Pediatric Acute Myeloid Leukemia Expressing <i>KMT2A::MLLT10</i>
Prognostic Value of Molecular Genetic Measurable Residual Disease ( <span>MRD</span> ) Monitoring in Pediatric Acute Myeloid Leukemia Expressing <i>KMT2A::MLLT10</i> Open
Objectives Pediatric AML with KMT2A::MLLT10 accounts for 10%–15% of KMT2A ‐rearranged AML and is associated with poor prognosis. Lately, the assessment of measurable residual disease (MRD) by reverse transcription quantitative polymerase c…
View article: Leukemic Cells Manipulate MSCs Bioelectrical Signals to Reshape the Bone Marrow Niche
Leukemic Cells Manipulate MSCs Bioelectrical Signals to Reshape the Bone Marrow Niche Open
Mesenchymal stromal cells (MSCs) are key components of the tumor microenvironment (TME), influencing leukemia progression through poorly understood mechanisms. We investigated the bioelectrical properties of MSCs derived from pediatric AML…
View article: Influence of Nucleophosmin ( <i>NPM1</i> ) Genotypes on Outcome of Patients With AML: An AIEOP-BFM and COG-SWOG Intergroup Collaboration
Influence of Nucleophosmin ( <i>NPM1</i> ) Genotypes on Outcome of Patients With AML: An AIEOP-BFM and COG-SWOG Intergroup Collaboration Open
PURPOSE Several genomic subsets of NPM1 mutations with varying sequences (type A, B, D, etc) have been identified. Despite molecular heterogeneity, NPM1 mutations cumulatively portend a more favorable outcome, but biology and prognostic im…
View article: Novel Promising Therapeutic Strategies for Advancing the Treatment of <i>KMT2A</i>-Rearranged AML
Novel Promising Therapeutic Strategies for Advancing the Treatment of <i>KMT2A</i>-Rearranged AML Open
BACKGROUND. In recent years, cancer research on genome and transcriptome sequencing tuned the scenario that was previously conceived as targetable in pediatric acute myeloid leukemia (AML), but the actual dearth of new agents approval unde…
View article: <scp>CD72</scp> is a pan‐tumor antigen associated to pediatric acute leukemia
<span>CD72</span> is a pan‐tumor antigen associated to pediatric acute leukemia Open
In the development of novel immunotherapeutic approaches, the step of target identification is a challenging process, because it aims at identifying robust tumor‐associated antigens (TAAs) specific for the pathological population and causi…
View article: P414: PATIENT-DERIVED XENOGRAFT MODELS ARE THE LEADING STRATEGY TO IDENTIFY NEW AGENTS FOR PEDIATRIC ACUTE MYELOID LEUKEMIA
P414: PATIENT-DERIVED XENOGRAFT MODELS ARE THE LEADING STRATEGY TO IDENTIFY NEW AGENTS FOR PEDIATRIC ACUTE MYELOID LEUKEMIA Open
Background: Pediatric acute myeloid leukemia (AML) is a life-threatening disease with chemotherapy and hematopoietic stem cell transplantation still representing the standard of care. Nowadays, most of children affected from AML reached co…
View article: P435: NOVEL COMPOUNDS TO TARGET KMT2A-REARRANGED PEDIATRIC ACUTE MYELOID LEUKEMIA
P435: NOVEL COMPOUNDS TO TARGET KMT2A-REARRANGED PEDIATRIC ACUTE MYELOID LEUKEMIA Open
Background: In pediatric acute myeloid leukemia (AML), fusions involving lysine methyltransferase 2A (KMT2A) are considered hallmarks of aggressive AML, representing a challenge for the development of targeted specific therapeutic agents t…
View article: Molecular Measurable Residual Disease Assessment before Hematopoietic Stem Cell Transplantation in Pediatric Acute Myeloid Leukemia Patients: A Retrospective Study by the I-BFM Study Group
Molecular Measurable Residual Disease Assessment before Hematopoietic Stem Cell Transplantation in Pediatric Acute Myeloid Leukemia Patients: A Retrospective Study by the I-BFM Study Group Open
Hematopoietic stem cell transplantation (HSCT) is a curative post-remission treatment in patients with acute myeloid leukemia (AML), but relapse after transplant is still a challenging event. In recent year, several studies have investigat…
View article: P398: DEVELOPMENT AND CHARACTERIZATION OF PRECLINICAL IN VIVO MODELS FOR THE IDENTIFICATION AND TESTING OF NEW THERAPEUTIC APPROACHES FOR PEDIATRIC ACUTE MYELOID LEUKEMIA
P398: DEVELOPMENT AND CHARACTERIZATION OF PRECLINICAL IN VIVO MODELS FOR THE IDENTIFICATION AND TESTING OF NEW THERAPEUTIC APPROACHES FOR PEDIATRIC ACUTE MYELOID LEUKEMIA Open
Background: In pediatric acute myeloid leukemia (AML) chemotherapy is the standard of care, but >25% of patients still relapse and after a disease recurrence the survival probability is extremely low (<50%). To ameliorate patients’ outcome…
View article: P1398: INSIGHT INTO ACUTE MYELOID LEUKEMIA INDUCED MSC SECRETOME TO REROUTE THE COURSE OF LEUKEMIA BONE MARROW NICHE
P1398: INSIGHT INTO ACUTE MYELOID LEUKEMIA INDUCED MSC SECRETOME TO REROUTE THE COURSE OF LEUKEMIA BONE MARROW NICHE Open
Background: Bone marrow (BM) niche sustains hematopoiesis and hematopoietic stem cells (HSCs) homeostasis, but at Acute Myeloid Leukemia (AML) onset it undergoes to drastic remodeling to support the disease, thus impeding HSCs functions. T…
View article: P387: UNRAVELING LEUKEMIC STEM CELLS MITOCHONDRIAL DEPENDENCY IN PEDIATRIC ACUTE MYELOID LEUKEMIA
P387: UNRAVELING LEUKEMIC STEM CELLS MITOCHONDRIAL DEPENDENCY IN PEDIATRIC ACUTE MYELOID LEUKEMIA Open
Background: Relapse still represents an unsolved problem for children with acute myeloid leukemia (AML), therefore more effective therapeutic strategies are needed for a complete blasts eradication. Leukemic stem cells (LSCs) have been pro…
View article: Novel Compounds Synergize With Venetoclax to Target KMT2A-Rearranged Pediatric Acute Myeloid Leukemia
Novel Compounds Synergize With Venetoclax to Target KMT2A-Rearranged Pediatric Acute Myeloid Leukemia Open
In pediatric acute myeloid leukemia (AML), fusions involving lysine methyltransferase 2A (KMT2A) are considered hallmarks of aggressive AML, for whom the development of targeted specific therapeutic agents to ameliorate classic chemotherap…
View article: NPM1 Mutational Status Underlines Different Biological Features in Pediatric AML
NPM1 Mutational Status Underlines Different Biological Features in Pediatric AML Open
Nucleophosmin (NPM1) is a nucleocytoplasmic shuttling protein, predominantly located in the nucleolus, that regulates a multiplicity of different biological processes. NPM1 localization in the cell is finely tuned by specific signal motifs…
View article: Targeting mesenchymal stromal cells plasticity to reroute acute myeloid leukemia course
Targeting mesenchymal stromal cells plasticity to reroute acute myeloid leukemia course Open
Bone marrow (BM) microenvironment contributes to the regulation of normal hematopoiesis through a finely tuned balance of self-renewal and differentiation processes, cell-cell interaction and secretion of cytokines that during leukemogenes…
View article: <scp>CD56</scp>, <scp>HLA‐DR,</scp> and <scp>CD45</scp> recognize a subtype of childhood <scp>AML</scp> harboring <scp>CBFA2T3‐GLIS2</scp> fusion transcript
<span>CD56</span>, <span>HLA‐DR,</span> and <span>CD45</span> recognize a subtype of childhood <span>AML</span> harboring <span>CBFA2T3‐GLIS2</span> fusion transcript Open
The presence of CBFA2T3‐GLIS2 fusion gene has been identified in childhood Acute Myeloid Leukemia (AML). In view of the genomic studies indicating a distinct gene expression profile, we evaluated the role of immunophenotyping in characteri…
View article: Thioridazine requires calcium influx to induce MLL-AF6–rearranged AML cell death
Thioridazine requires calcium influx to induce MLL-AF6–rearranged AML cell death Open
In pediatric acute myeloid leukemia (AML), intensive chemotherapy and allogeneic hematopoietic stem cell transplantation are the cornerstones of treatment in high-risk cases, with severe late effects and a still high risk of disease recurr…
View article: Knockdown of APOPT1/COA8 Causes Cytochrome c Oxidase Deficiency, Neuromuscular Impairment, and Reduced Resistance to Oxidative Stress in Drosophila melanogaster
Knockdown of APOPT1/COA8 Causes Cytochrome c Oxidase Deficiency, Neuromuscular Impairment, and Reduced Resistance to Oxidative Stress in Drosophila melanogaster Open
Cytochrome c oxidase (COX) deficiency is the biochemical hallmark of several mitochondrial disorders, including subjects affected by mutations in apoptogenic-1 (APOPT1), recently renamed as COA8 (HGNC:20492). Loss-of-function mutations are…
View article: Label-free, real-time on-chip sensing of living cancer cell via grating-coupled surface plasmon resonance
Label-free, real-time on-chip sensing of living cancer cell via grating-coupled surface plasmon resonance Open
The application of nanotechnologies to address biomedical questions is a key strategy for innovation in biomedical research. Among others, a key point consists in the availability of nanotechnologies for monitoring cellular processes in a …
View article: PS1226 DEVELOPMENT OF INNOVATIVE PRECLINICAL IN VITRO AND IN VIVO TOOLS FOR AN EFFECTIVE THERAPEUTIC STRATEGY IN PEDIATRIC ACUTE MYELOID LEUKEMIA
PS1226 DEVELOPMENT OF INNOVATIVE PRECLINICAL IN VITRO AND IN VIVO TOOLS FOR AN EFFECTIVE THERAPEUTIC STRATEGY IN PEDIATRIC ACUTE MYELOID LEUKEMIA Open
Background: Diagnosis, treatment, minimal residual disease monitoring, and outcome of pediatric acute myeloid leukemia (AML) have made enormous progress during the past decade, although chemotherapy is still the pillar of pediatric treatme…
View article: Modulation of miR-210 alters phasing of circadian locomotor activity and impairs projections of PDF clock neurons in Drosophila melanogaster
Modulation of miR-210 alters phasing of circadian locomotor activity and impairs projections of PDF clock neurons in Drosophila melanogaster Open
Single microRNAs are usually associated with hundreds of putative target genes that can influence multiple phenotypic traits in Drosophila, ranging from development to behaviour. We investigated the function of Drosophila miR-210 in circad…
View article: A three‐mi<scp>RNA</scp>‐based expression signature at diagnosis can predict occurrence of relapse in children with t(8;21) <i><scp>RUNX</scp>1</i>‐<i><scp>RUNX</scp>1T1</i> acute myeloid leukaemia
A three‐mi<span>RNA</span>‐based expression signature at diagnosis can predict occurrence of relapse in children with t(8;21) <i><span>RUNX</span>1</i>‐<i><span>RUNX</span>1T1</i> acute myeloid leukaemia Open
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View article: ZNF521 sustains the differentiation block in MLL-rearranged acute myeloid leukemia
ZNF521 sustains the differentiation block in MLL-rearranged acute myeloid leukemia Open
Zinc finger protein 521 (ZNF521) is a multiple zinc finger transcription factor and a strong candidate as regulator of hematopoietic stem cell homeostasis. Recently, independent gene expression profile studies have evidenced a positive cor…
View article: CREB engages C/EBPδ to initiate leukemogenesis
CREB engages C/EBPδ to initiate leukemogenesis Open
cAMP response element binding protein (CREB) is frequently overexpressed in acute myeloid leukemia (AML) and acts as a proto-oncogene; however, it is still debated whether such overactivation alone is able to induce leukemia as its pathoge…