Claudiana Lameu
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View article: P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior Open
View article: Animal models of xenograft-induced cachexia of patient-derived pancreatic cancer: exploring potential new biomarkers and treatment targets
Animal models of xenograft-induced cachexia of patient-derived pancreatic cancer: exploring potential new biomarkers and treatment targets Open
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer often accompanied by cachexia, a condition marked by physical decline, anorexia, and reduced quality of life. Cachexia varies in severity, categorized as precach…
View article: Impairment of adenosine signaling disrupts early embryo development: unveiling the underlying mechanisms
Impairment of adenosine signaling disrupts early embryo development: unveiling the underlying mechanisms Open
Purinergic signaling has been implicated in many biological functions, including development. In this study, we investigate the functions of extracellular adenosine and adenosine receptors using a mouse embryonic stem cell (ESC) line and m…
View article: Purinergic system in cancer stem cells
Purinergic system in cancer stem cells Open
View article: Eicosapentaenoic acid-rich oil supplementation activates PPAR-γ and delays skin wound healing in type 1 diabetic mice
Eicosapentaenoic acid-rich oil supplementation activates PPAR-γ and delays skin wound healing in type 1 diabetic mice Open
Delayed wound healing is a devastating complication of diabetes and supplementation with fish oil, a source of anti-inflammatory omega-3 (ω-3) fatty acids including eicosapentaenoic acid (EPA), seems an appealing treatment strategy. Howeve…
View article: Purinergic Receptor Antagonist A438079 Disrupts Benzo[a]pyrene-Mediated IL-1β, CYP1A and CYP1B Transcript Induction Pathway in Zebrafish: Insights into Possible Mechanisms.
Purinergic Receptor Antagonist A438079 Disrupts Benzo[a]pyrene-Mediated IL-1β, CYP1A and CYP1B Transcript Induction Pathway in Zebrafish: Insights into Possible Mechanisms. Open
The deleterious effects of benzo[a]pyrene are mainly due its metabolites generated by CYP1 metabolism. P2X7 is an important member of purinergic receptors involved in diverse cell signaling cascades, as the inflammasome pathway. Receptor b…
View article: Malignant wound – The influence of oil components in flubendazole-loaded nanoemulsions in A549 lung cancer xenograft-bearing mice
Malignant wound – The influence of oil components in flubendazole-loaded nanoemulsions in A549 lung cancer xenograft-bearing mice Open
View article: P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma
P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma Open
Drug resistance is a major challenge for all oncological treatments that involve the use of cytotoxic agents. Recent therapeutic alternatives cannot circumvent the ability of cancer cells to adapt or alter the natural selection of resistan…
View article: Revisiting Flubendazole Through Nanocrystal Technology: Statistical Design, Characterization and Its Potential Inhibitory Effect on Xenografted Lung Tumor Progression in Mice
Revisiting Flubendazole Through Nanocrystal Technology: Statistical Design, Characterization and Its Potential Inhibitory Effect on Xenografted Lung Tumor Progression in Mice Open
View article: Complex diseases demand novel treatment strategies: understanding drug combination
Complex diseases demand novel treatment strategies: understanding drug combination Open
For many multigene or multifactorial diseases, the one-drug therapy for inhibiting a defined molecular target is often less effective than combined treatments. Typically, drug combination therapies are multitargeted, so the mechanisms or e…
View article: Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor
Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor Open
The heterogeneity of tumor cell mass and the plasticity of cancer cell phenotypes in solid tumors allow for the insurgence of resistant and metastatic cells, responsible for cancer patients’ clinical management’s main challenges. Among sev…
View article: Implications of SARS-Cov-2 infection on eNOS and iNOS activity: Consequences for the respiratory and vascular systems
Implications of SARS-Cov-2 infection on eNOS and iNOS activity: Consequences for the respiratory and vascular systems Open
View article: Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology
Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology Open
View article: Volume 97A, Number 9, September 2020 Table of Contents
Volume 97A, Number 9, September 2020 Table of Contents Open
ON THE COVER: Imaging cycler microscopy (ICM) can resolve large toponomes in intact cells and tissues and has provided new insights into the treatment of amyotrophic lateral sclerosis (ALS).ICM was used to monitor the effect of extracorpor…
View article: The P2X7 Receptor: Central Hub of Brain Diseases
The P2X7 Receptor: Central Hub of Brain Diseases Open
The P2X7 receptor is a cation channel activated by high concentrations of adenosine triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming a wide pore that leads to cell death and increased release of AT…
View article: Insights in Chloroquine Action: Perspectives and Implications in Malaria and <scp>COVID</scp>‐19
Insights in Chloroquine Action: Perspectives and Implications in Malaria and <span>COVID</span>‐19 Open
Malaria is a threat to human mankind and kills about half a million people every year. On the other hand, COVID‐19 resulted in several hundred thousand deaths since December 2019 and remains without an efficient and safe treatment. The ant…
View article: Using Cytometry for Investigation of Purinergic Signaling in Tumor‐Associated Macrophages
Using Cytometry for Investigation of Purinergic Signaling in Tumor‐Associated Macrophages Open
Tumor‐associated macrophages are widely recognized for their importance in guiding pro‐tumoral or antitumoral responses. Mediating inflammation or immunosuppression, these cells support many key events in cancer progression: cell growth, c…
View article: ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington’s disease: a novel approach for cell clock research
ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington’s disease: a novel approach for cell clock research Open
View article: Publisher Correction: Combination of Chemical and Neurotrophin Stimulation Modulates Neurotransmitter Receptor Expression and Activity in Transdifferentiating Human Adipose Stromal Cells
Publisher Correction: Combination of Chemical and Neurotrophin Stimulation Modulates Neurotransmitter Receptor Expression and Activity in Transdifferentiating Human Adipose Stromal Cells Open
View article: Combination of Chemical and Neurotrophin Stimulation Modulates Neurotransmitter Receptor Expression and Activity in Transdifferentiating Human Adipose Stromal Cells
Combination of Chemical and Neurotrophin Stimulation Modulates Neurotransmitter Receptor Expression and Activity in Transdifferentiating Human Adipose Stromal Cells Open
View article: Where do we aspire to publish? A position paper on scientific communication in biochemistry and molecular biology
Where do we aspire to publish? A position paper on scientific communication in biochemistry and molecular biology Open
The scientific publication landscape is changing quickly, with an enormous increase in options and models. Articles can be published in a complex variety of journals that differ in their presentation format (online-only or in-print), edito…
View article: Calcium signalling: A common target in neurological disorders and neurogenesis
Calcium signalling: A common target in neurological disorders and neurogenesis Open
View article: Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation
Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation Open
View article: Aptamers: novelty tools for cancer biology
Aptamers: novelty tools for cancer biology Open
Although the term 'cancer' was still over two thousand years away of being coined, the first known cases of the disease date back to about 3000BC, in ancient Egypt. Five thousand years later, still lacking a cure, it has become one of the …
View article: Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis
Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis Open
Bone marrow metastasis occurs in approximately 350,000 patients that annually die in the U.S. alone. In view of the importance of tumor cell migration into the bone marrow, we have here investigated effects of various concentrations of str…
View article: A bradykinin-potentiating peptide (BPP-10c) from Bothrops jararaca induces changes in seminiferous tubules
A bradykinin-potentiating peptide (BPP-10c) from Bothrops jararaca induces changes in seminiferous tubules Open
Background The testis-specific isoform of angiotensin-converting enzyme (tACE) is exclusively expressed in germ cells during spermatogenesis. Although the exact role of tACE in male fertility is unknown, it clearly plays a critical functio…
View article: Stem cell contributions to neurological disease modeling and personalized medicine
Stem cell contributions to neurological disease modeling and personalized medicine Open
View article: Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation
Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation Open
During brain development, cells proliferate, migrate and differentiate in highly accurate patterns. In this context, published results indicate that bradykinin functions in neural fate determination, favoring neurogenesis and migration. Ho…
View article: Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells
Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells Open
View article: Additional file 3: Figure S2. of Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells
Additional file 3: Figure S2. of Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells Open
Extracellular nucleotides induce migration and adhesion of lung cancer cell lines. Panel A. Chemotaxis of tested lung cancer cell lines in response to extracellular TTP, UTP, CTP, and GTP. Chemotaxis in response to a supraphysiological dos…