Explanipedia

Can the intensive care requirement score improve triage at the emergency department for acutely intoxicated patients? Open

Dylan W. de Lange, Sylvia Brinkman, Claudine C. Hunault · 2025

Following adjustment, the intensive care requirement score can assist in reducing unnecessary intensive care unit admissions among intoxicated patients presenting to the emergency department.

Comparative evaluation of the ability to detect major cardiac events with the modified cocaine history, electrocardiogram, age, risk factors and troponin (HEART) score, HEART pathway and original HEART score in patients with cocaine-associated chest pain presenting at the emergency department Open

Femke M. J. Gresnigt, J van Essen, Claudine C. Hunault, Eric J. F. Franssen, Dylan W. de Lange , et al. · 2025

All three risk stratification scores performed well in a low-risk population with cocaine-associated chest pain, with a percentage of 0.7% of patients with a missed major adverse cardiovascular event.

Case report: Successful treatment of a thallium sulfate intoxication in a dog with use of Prussian blue Open

Fergal M. McDermott, Anne A. Kan, Claudine C. Hunault, Joris H. Robben, Dylan W. de Lange , et al. · 2025

Soluble thallium salts are highly toxic, with mortality rates exceeding 70% in animals compared to 6%−15% in humans. Early identification of thallium intoxicated patients and decreasing the toxic load by targeted treatment using Prussian B…

The INTOXICATE study: methodology and preliminary results of a prospective observational study Open

Samanta M. Zwaag, Irma S. van den Hengel-Koot, Stuart Baker, Patrick Druwé, Muhammed Elhadi , et al. · 2024

OSF registration ID: osf.io/7e5uy.

The INTOXICATE study: Methodology, experience and preliminary results of a prospective cohort study Open

Samanta M. Zwaag, Irma S. van den Hengel-Koot, Stuart Baker, Patrick Druwé, Muhammed Elhadi , et al. · 2024

Background No practice-based, multicenter database of poisoned patients admitted to intensive care units (ICUs) exists. The INTOXICATE study, endorsed by the ESICM and EAPCCT, aimed to collect detailed data on such patients. We hypothesize…

Significant increase in the number of occupational exposures reported to the Dutch Poisons Information Centre (2016–2022): the importance of poison centre data in health surveillance Open

Anja P. G. Wijnands, Maël Thielman, Claudine C. Hunault, Arjen Koppen, Dylan W. de Lange , et al. · 2024

The continuing increase in the number of workplace incidents involving hazardous substances is of concern. A comprehensive and multidisciplinary approach should be taken to gain a full understanding of occupational exposure to hazardous su…

Significant Increase in Deliberate Self-Poisonings Among Adolescents During the Second Year of the COVID-19 Pandemic Open

Arjen Koppen, Ilze M. J. Thoonen, Claudine C. Hunault, Agnes G. van Velzen, Dylan W. de Lange , et al. · 2023

The strong increase in the number of DSPs during the second year of the COVID-19 pandemic suggests that long-term containment measures such as quarantines, lockdowns, and school closures may enhance self-harm behavior among adolescents, es…

Correction to: Unbound Plasma, Total Plasma and Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation Open

Maaike A. Sikma, Erik M. van Maarseveen, Claudine C. Hunault, J. Marta Moreno, Ed A. van de Graaf , et al. · 2022

Alarming increase in poisonings from recreational nitrous oxide use after a change in EU-legislation, inquiries to the Dutch Poisons Information Center Open

Antoinette van Riel, Claudine C. Hunault, Irma S. van den Hengel-Koot, Johanna J. Nugteren–van Lonkhuyzen, Dylan W. de Lange , et al. · 2021

The rate of N₂O poisonings increased alarmingly in the Netherlands. An increasing proportion of patients reported problematic heavy or frequent use, accompanied by chronic toxicity.

Pregabalin poisoning: Evaluation of dose‐toxicity relationship Open

Saskia J. Rietjens, Maaike A. Sikma, Claudine C. Hunault, Dylan W. de Lange, Laura Hondebrink · 2021

Context Pregabalin poisoning is mostly benign, although coma and convulsions occasionally occur. Aim To determine the dose‐toxicity relationship of pregabalin. Methods Dose‐toxicity data of isolated pregabalin poisonings were collected fro…

Estimation of the risk of local and systemic effects in infants after ingestion of low-concentrated weak acids from descaling products Open

Arjen Koppen, Claudine C. Hunault, Regina G.D.M. van Kleef, Agnes G. van Velzen, Remco H.S. Westerink , et al. · 2021

Commercially available electric kettle descaling products may pose a health risk to infants in case of accidental ingestion since the pH of some of these products can be very low, even when diluted 10-times or in the presence of baby milk …

Unbound Plasma, Total Plasma, and Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation Open

Maaike A. Sikma, Erik M. van Maarseveen, Claudine C. Hunault, J. Marta Moreno, Ed A. van de Graaf , et al. · 2019

Clinical Pharmacokinetics and Impact of Hematocrit on Monitoring and Dosing of Tacrolimus Early After Heart and Lung Transplantation Open

Maaike A. Sikma, Claudine C. Hunault, Alwin D. R. Huitema, Dylan W. de Lange, Erik M. van Maarseveen · 2019

The calcineurin inhibitor tacrolimus is an effective immunosuppressant and is extensively used in solid organ transplantation. In the first week after heart and lung transplantation, tacrolimus dosing is difficult due to considerable physi…

High Variability of Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation Open

Maaike A. Sikma, Claudine C. Hunault, Erik M. van Maarseveen, Alwin D. R. Huitema, Ed A. van de Graaf , et al. · 2019

The high variability of tacrolimus pharmacokinetics early after thoracic organ transplantation is largely due to excessive variability in bioavailability, making individualised dosing based on measured concentrations futile. To bypass this…

New psychoactive substances (NPS) in the Netherlands: occurrence in forensic drug samples, consumer drug samples and poisons center exposures between 2013 and 2017 Open

Laura Hondebrink, Johanna J. Nugteren–van Lonkhuyzen, Claudine C. Hunault, Jorrit van den Berg, Daan van der Gouwe , et al. · 2019

Background and Aims Although European‐wide data on the new psychoactive substances (NPS) drug market are available, country‐specific data are limited. We studied recent NPS trend data relative to all recreational drugs on the Dutch drug ma…

Association of Whole Blood Tacrolimus Concentrations with Kidney Injury in Heart Transplantation Patients Open

Maaike A. Sikma, Claudine C. Hunault, J. H. Kirkels, Marianne C. Verhaar, Jozef Kesecioğlu , et al. · 2017

Supratherapeutic whole-blood tacrolimus trough concentrations are independently associated with the development of AKI in adult heart transplantation patients. More stringent dosing of tacrolimus early after transplantation may be critical…

Cost-effectiveness of ‘immediate IVF’ versus ‘delayed IVF’: a prospective study Open

Marinus J.C. Eijkemans, F.A.M. Kersten, A.M.E. Lintsen, Claudine C. Hunault, Clazien Bouwmans , et al. · 2017

Supported by Netherlands Organisation for Health Research and Development (ZonMW, grant 945-12-013). ZonMW had no role in designing the study, data collection, analysis and interpretation of data or writing of the report. Competing interes…

High tacrolimus blood concentrations early after lung transplantation and the risk of kidney injury Open

Maaike A. Sikma, Claudine C. Hunault, E.A. van de Graaf, Marianne C. Verhaar, Jozef Kesecioğlu , et al. · 2017

• For the first time, supra-therapeutic whole-blood tacrolimus trough concentrations are related to the emergence of acute kidney injury in the first days after lung transplantation. • Supra-therapeutic whole-blood tacrolimus trough concen…

Modeling the effect of succimer (DMSA; dimercaptosuccinic acid) chelation therapy in patients poisoned by lead Open

J.C.H. van Eijkeren, J. Daniël N. Olie, Sally Bradberry, J Allister Vale, Irma de Vries , et al. · 2016

Context: Kinetic models could assist clinicians potentially in managing cases of lead poisoning. Several models exist that can simulate lead kinetics but none of them can predict the effect of chelation in lead poisoning. Our aim wa…

Modeling the effect of succimer (DMSA; dimercaptosuccinic acid) chelation therapy in patients poisoned by lead Open

J.C.H. van Eijkeren, J. Daniël N. Olie, Sally Bradberry, J Allister Vale, Irma de Vries , et al. · 2016

Context: Kinetic models could assist clinicians potentially in managing cases of lead poisoning. Several models exist that can simulate lead kinetics but none of them can predict the effect of chelation in lead poisoning. Our aim wa…

Modelling dimercaptosuccinic acid (DMSA) plasma kinetics in humans Open

J.C.H. van Eijkeren, J. Daniël N. Olie, Sally Bradberry, J Allister Vale, Irma de Vries , et al. · 2016

A simple kinetic model simulating the kinetics of DMSA in humans has been developed and validated. The interest of this model lies in the future potential to use it to predict blood lead concentrations in lead-poisoned patients treated wit…

Modeling the effect of succimer (DMSA; dimercaptosuccinic acid) chelation therapy in patients poisoned by lead Open

J.C.H. van Eijkeren, J. Daniël N. Olie, Sally Bradberry, J Allister Vale, Irma de Vries , et al. · 2016

Context: Kinetic models could assist clinicians potentially in managing cases of lead poisoning. Several models exist that can simulate lead kinetics but none of them can predict the effect of chelation in lead poisoning. Our aim wa…

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