Claudine Manach
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View article: BioTransformer 4.0 a comprehensive computational tool for small molecule metabolism prediction
BioTransformer 4.0 a comprehensive computational tool for small molecule metabolism prediction Open
BioTransformer 4.0, the successor to BioTransformer 3.0, is a freely available in silico metabolism prediction tool. It integrates both knowledge-based and machine learning approaches to predict metabolites for small molecules using one of…
View article: Biomarkers of (poly)phenol intake: a systematic review
Biomarkers of (poly)phenol intake: a systematic review Open
(Poly)phenols in plant-based foods contribute to the prevention of non-communicable diseases, yet defining their optimal intake remains challenging. Biomarkers provide a more objective alternative to self-reported dietary assessments, but …
View article: PhenolQuest: a new reference FFQ for a more precise and comparable assessment of (poly)phenol intake in Europe
PhenolQuest: a new reference FFQ for a more precise and comparable assessment of (poly)phenol intake in Europe Open
Development of a new FFQ for (poly)phenol intake.
View article: Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers
Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers Open
There is an increasing body of evidence indicating that phenolic compounds derived from microbiota-mediated breakdown of dietary (poly)phenolics in the colon are at least partially responsible for the beneficial effects of a plant-based di…
View article: Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing
Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing Open
Hippocampal neurogenesis (HN) occurs throughout the life course and is important for memory and mood. Declining with age, HN plays a pivotal role in cognitive decline (CD), dementia, and late-life depression, such that altered HN could rep…
View article: Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies
Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies Open
This systematic review provides an overview of the available evidence on the inter-individual variability (IIV) in the absorption, distribution, metabolism, and excretion (ADME) of phenolic metabolites and its determinants. Human studies w…
View article: Exploring the Inter-Individual Variability in Response to Food in Seniors Living at Home: The MetabotypAGE Project
Exploring the Inter-Individual Variability in Response to Food in Seniors Living at Home: The MetabotypAGE Project Open
There is a high inter-individual variability in response to food, determined by multiple interacting factors, such as age, sex, genotype, gut microbiota, eating behaviours, physical activity or socio-demographic factors. Previous studies d…
View article: A Mediterranean Diet‐Based Metabolomic Score and Cognitive Decline in Older Adults: A Case–Control Analysis Nested within the Three‐City Cohort Study
A Mediterranean Diet‐Based Metabolomic Score and Cognitive Decline in Older Adults: A Case–Control Analysis Nested within the Three‐City Cohort Study Open
Scope Evidence on the Mediterranean diet (MD) and age‐related cognitive decline (CD) is still inconclusive partly due to self‐reported dietary assessment. The aim of the current study is to develop an MD‐ metabolomic score (MDMS) and inves…
View article: A Systematic Review and Comprehensive Evaluation of Human Intervention Studies to Unravel the Bioavailability of Hydroxycinnamic Acids
A Systematic Review and Comprehensive Evaluation of Human Intervention Studies to Unravel the Bioavailability of Hydroxycinnamic Acids Open
Significance: Hydroxycinnamic acids (HCAs) are the main phenolic acids in the western diet. Harmonizing the available information on the absorption, distribution, metabolism, and excretion (ADME) of HCAs is fundamental to unr…
View article: Systematic Review on the Metabolic Interest of Glucosinolates and Their Bioactive Derivatives for Human Health
Systematic Review on the Metabolic Interest of Glucosinolates and Their Bioactive Derivatives for Human Health Open
In the last decade, most of the evidence on the clinical benefits of including cruciferous foods in the diet has been focused on the content of glucosinolates (GSL) and their corresponding isothiocyanates (ITC), and mercapturic acid pathwa…
View article: Revisiting the bioavailability of flavan-3-ols in humans: A systematic review and comprehensive data analysis
Revisiting the bioavailability of flavan-3-ols in humans: A systematic review and comprehensive data analysis Open
This systematic review summarizes findings from human studies investigating the different routes of absorption, metabolism, distribution and excretion (ADME) of dietary flavan-3-ols and their circulating metabolites in healthy subjects. Li…
View article: Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12‐Year Prospective Study
Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12‐Year Prospective Study Open
Scope Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented and often inconsistent. Methods and Results The article studies the long‐term prospective Three‐Cit…
View article: 海外におけるポリフェノールデータベースの紹介と日本における現状
海外におけるポリフェノールデータベースの紹介と日本における現状 Open
International audience
View article: Monoterpenes: current knowledge on food source, metabolism, and health effects
Monoterpenes: current knowledge on food source, metabolism, and health effects Open
Monoterpenes, volatile metabolites produced by plants, are involved in the taste and aroma perception of fruits and vegetables and have been used for centuries in gastronomy, as food preservatives and for therapeutic purposes. Biological a…
View article: Data sharing in PredRet for accurate prediction of retention time: Application to plant food bioactive compounds
Data sharing in PredRet for accurate prediction of retention time: Application to plant food bioactive compounds Open
View article: Monoterpenes: current knowledge on food source, metabolism, and health effects
Monoterpenes: current knowledge on food source, metabolism, and health effects Open
Monoterpenes, volatile metabolites produced by plants, are involved in the taste and aroma perception of fruits and vegetables and have been used for centuries in gastronomy, as food preservatives and for therapeutic purposes. Biological a…
View article: Metabolomic Changes after Coffee Consumption: New Paths on the Block
Metabolomic Changes after Coffee Consumption: New Paths on the Block Open
Scope Several studies suggest that regular coffee consumption may help preventing chronic diseases, but the impact of daily intake and the contribution of coffee metabolites in disease prevention are still unclear. The present study aims a…
View article: Food intake biomarkers for berries and grapes
Food intake biomarkers for berries and grapes Open
View article: Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites
Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites Open
View article: Biomarkers of intake for tropical fruits
Biomarkers of intake for tropical fruits Open
View article: Food intake biomarkers for green leafy vegetables, bulb vegetables, and stem vegetables: a review
Food intake biomarkers for green leafy vegetables, bulb vegetables, and stem vegetables: a review Open
View article: Why interindividual variation in response to consumption of plant food bioactives matters for future personalised nutrition
Why interindividual variation in response to consumption of plant food bioactives matters for future personalised nutrition Open
Food phytochemicals are increasingly considered to play a key role in the cardiometabolic health effects of plant foods. However, the heterogeneity in responsiveness to their intake frequently observed in clinical trials can hinder the ben…
View article: Untargeted plasma metabolomic profiles associated with overall diet in women from the SU.VI.MAX cohort
Untargeted plasma metabolomic profiles associated with overall diet in women from the SU.VI.MAX cohort Open
View article: A Review of Factors Affecting Anthocyanin Bioavailability: Possible Implications for the Inter-Individual Variability
A Review of Factors Affecting Anthocyanin Bioavailability: Possible Implications for the Inter-Individual Variability Open
Anthocyanins are dietary bioactive compounds showing a range of beneficial effects against cardiovascular, neurological, and eye conditions. However, there is, as for other bioactive compounds in food, a high inter and intra-individual var…
View article: Future prospects for dissectinginter-individual variability in the absorption, distribution and elimination of plantbioactives of relevance for cardiometabolic endpoints
Future prospects for dissectinginter-individual variability in the absorption, distribution and elimination of plantbioactives of relevance for cardiometabolic endpoints Open
View article: Targeting the delivery of dietary plant bioactives to those who would benefit most: from science to practical applications
Targeting the delivery of dietary plant bioactives to those who would benefit most: from science to practical applications Open
Background A healthy diet and optimal lifestyle choices are amongst the most important actions for the prevention of cardiometabolic diseases. Despite this, it appears difficult to convince consumers to select more nutritious foods. Furthe…
View article: Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort
Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort Open
Scope Untargeted metabolomics may reveal preventive targets in cognitive aging, including within the food metabolome. Methods and results A case‐control study nested in the prospective Three‐City study includes participants aged ≥65 years …
View article: Discovery and Validation of Banana Intake Biomarkers Using Untargeted Metabolomics in Human Intervention and Cross-sectional Studies
Discovery and Validation of Banana Intake Biomarkers Using Untargeted Metabolomics in Human Intervention and Cross-sectional Studies Open
View article: BioTransformer: a comprehensive computational tool for small molecule metabolism prediction and metabolite identification
BioTransformer: a comprehensive computational tool for small molecule metabolism prediction and metabolite identification Open
View article: MOESM1 of BioTransformer: a comprehensive computational tool for small molecule metabolism prediction and metabolite identification
MOESM1 of BioTransformer: a comprehensive computational tool for small molecule metabolism prediction and metabolite identification Open
Additional file 1. Cited structures.