Claudio Ronco
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View article: Eryptosis in Acute Patients: A Hypothesis on Its Potential Clinical Impact and Current Gaps in Evidence
Eryptosis in Acute Patients: A Hypothesis on Its Potential Clinical Impact and Current Gaps in Evidence Open
Sepsis is a life-threatening condition driven by a dysregulated host response to infection and remains a leading cause of mortality and morbidity worldwide. Among the many mechanisms implicated in its pathophysiology, the contribution of e…
View article: Use of Oxiris membrane in real-world clinical practice in critical care patients: a multicenter observational study
Use of Oxiris membrane in real-world clinical practice in critical care patients: a multicenter observational study Open
The study was registered on ClinicalTrials.gov (Identifier: NCT03807414; Registration Date: June 28, 2019).
View article: Non-Protein-Coding RNA and Acute Kidney Injury: New Developments from Pathogenesis to Potential Biomarker
Non-Protein-Coding RNA and Acute Kidney Injury: New Developments from Pathogenesis to Potential Biomarker Open
Acute Kidney Injury (AKI) is a critical medical condition characterized by a sudden and significant decline in renal function over a short timeframe. Commonly triggered by factors such as sepsis, ischemia–reperfusion injury, or nephrotoxic…
View article: #2280 Cell-free plasma dna (cfDNA) in peritonitis is originated from apoptotic events and Caspase-3 activation
#2280 Cell-free plasma dna (cfDNA) in peritonitis is originated from apoptotic events and Caspase-3 activation Open
Background and Aims Plasma cell-free DNA (cfDNA) is a circulating extracellular DNA fragments and originates from inflammation and tissue damage. High levels of cfDNA have been reported in many clinical conditions, including CKD, hemodialy…
View article: #1691 Assessment of oXiris membrane adsorption towards Linezolid: implications for optimizing antibiotic therapy in critically ill patients
#1691 Assessment of oXiris membrane adsorption towards Linezolid: implications for optimizing antibiotic therapy in critically ill patients Open
Background and Aims Sepsis in critically ill patients triggers dysregulated inflammation, leading to organs dysfunction. Antibiotic therapy is crucial in treatment, but faces challenges in optimal delivery due to potential loss in the effl…
View article: #2337 Extracorporeal hemoadsorption therapy in the treatment of sepsis induced by Gram-negative bacteria: <i>in vitro</i> assessment of two new sorbent cartridges
#2337 Extracorporeal hemoadsorption therapy in the treatment of sepsis induced by Gram-negative bacteria: <i>in vitro</i> assessment of two new sorbent cartridges Open
Background and Aims Sepsis is one of the major causes of hospital mortality, characterized by a dysregulated immune response to infection that can lead to multiorgan failure and death. Gram-negative bacteria have emerged as primary contrib…
View article: #2377 Comparison and validation of two laboratory platforms for peritoneal NGAL in PD patients with and without peritonitis
#2377 Comparison and validation of two laboratory platforms for peritoneal NGAL in PD patients with and without peritonitis Open
Background and Aims Neutrophil gelatinase-associated lipocalin (NGAL) is a versatile protein known for its multifunctional roles, extending beyond its conventional use as a biomarker. It actively participates in many crucial biological pro…
View article: #1900 Artificial diuresis, a miniaturized device for ultrafiltration: comparison between animal study and mathematical model to assess ultrafiltration
#1900 Artificial diuresis, a miniaturized device for ultrafiltration: comparison between animal study and mathematical model to assess ultrafiltration Open
Background and Aims Fluid overload is associated with adverse outcome both in heart failure patients and critically ill patient admitted to intensive care. Extracorporeal ultrafiltration represents a solution to avoid acute kidney injury d…
View article: #2354 Endotoxin and cytokines removal with new microporous (CA) sorbent prototypes
#2354 Endotoxin and cytokines removal with new microporous (CA) sorbent prototypes Open
Background and Aims Endotoxin, also referred to as lipopolysaccharide (LPS), is a major stimulus of the inflammatory response capable of leading to sepsis and septic shock. Extracorporeal blood purification therapies are increasingly emplo…
View article: Tropical kidney diseases: underrepresented in foundational English-language medical education resources
Tropical kidney diseases: underrepresented in foundational English-language medical education resources Open
Tropical nephrology refers to kidney diseases commonly found in tropical and subtropical regions. These conditions, such as malaria-associated acute kidney injury, leptospirosis with renal involvement, schistosomiasis-related nephropathy, …
View article: Significance of neutrophil extracellular traps and low-density granulocytes in advanced chronic kidney disease (stage 5D) cases with COVID-19
Significance of neutrophil extracellular traps and low-density granulocytes in advanced chronic kidney disease (stage 5D) cases with COVID-19 Open
Coronavirus disease 2019 (COVID-19) affected billions of individuals globally, with symptoms ranging from isolated blood clotting to severe acute hypoxemic respiratory failure requiring intensive respiratory support ventilators. Those with…
View article: Inter‐organ crosstalk: The kidney's role in systemic health and disease
Inter‐organ crosstalk: The kidney's role in systemic health and disease Open
This review elucidates the critical role of inter‐organ crosstalk in systemic health, focusing on the kidney's interactions with the heart, bone marrow, lung, liver, intestine, bone‐vascular, and nervous system. These interactions are vita…
View article: Optimizing hepatitis B vaccination in chronic kidney disease: a comprehensive scoping review of strategies across CKD stages, dialysis, and transplant populations
Optimizing hepatitis B vaccination in chronic kidney disease: a comprehensive scoping review of strategies across CKD stages, dialysis, and transplant populations Open
This scoping review aims to comprehensively map and critically analyze existing evidence regarding the optimal HBV vaccination strategies-including vaccine types, schedules, immunogenicity, duration of protection, factors influencing seror…
View article: Hepato-Renal Crosstalk in Acute and Chronic Disease: From Shared Pathways to Therapeutic Targets
Hepato-Renal Crosstalk in Acute and Chronic Disease: From Shared Pathways to Therapeutic Targets Open
Hepato-renal crosstalk is a complex biological communication between liver and kidneys mediated by various factors, including cellular, endocrine, and paracrine molecules. This interaction highlights the functional consequences that damage…
View article: Red Cell Death in Renal Disease: The Role of Eryptosis in CKD and Dialysis Patients
Red Cell Death in Renal Disease: The Role of Eryptosis in CKD and Dialysis Patients Open
Eryptosis is a programmed cellular death involving red blood cells (RBCs). It is a physiological mechanism that leads to the removal of defective erythrocytes, similarly to apoptosis. Its typical features are cell shrinkage, cell membrane …
View article: Changes in Renal Venous Flow and Liberation from Renal Replacement Therapy in Patients with Acute Heart Failure
Changes in Renal Venous Flow and Liberation from Renal Replacement Therapy in Patients with Acute Heart Failure Open
Introduction: In acute heart failure (AHF), the factors associated with successful renal replacement therapy (RRT) discontinuation are largely undefined. We hypothesized that improvements in Doppler-derived renal venous flow (RVF) waveform…
View article: Collagen Type IV Variants and Kidney Cysts: Decoding the COL4A Puzzle
Collagen Type IV Variants and Kidney Cysts: Decoding the COL4A Puzzle Open
Pathogenic variants in type IV collagen genes (COL4A3, COL4A4, COL4A5) are classically associated with Alport syndrome (AS), a hereditary nephropathy primarily affecting the glomerular basement membrane (GBM). Recent findings, however, sug…
View article: Urinary and Plasma miRNAs in the Early Detection of Acute Kidney Injury and Their Possible Role as Therapeutic Targets
Urinary and Plasma miRNAs in the Early Detection of Acute Kidney Injury and Their Possible Role as Therapeutic Targets Open
Acute Kidney Injury (AKI) is a severe clinical condition featured by a rapid decrease in kidney function in a short period of time. AKI, which is often secondary to sepsis, ischemia-reperfusion and drug toxicity, is associated to high morb…
View article: Assessment of Safety and Efficacy of Expanded Hemodialysis with Medium Cut-Off Dialyzer Compared to Haemodiafiltration
Assessment of Safety and Efficacy of Expanded Hemodialysis with Medium Cut-Off Dialyzer Compared to Haemodiafiltration Open
Background: Removal of large uraemic toxins is still a challenge. Haemodiafiltration (HDF) has produced some results, although large convective volume, optimal vascular access to increase the blood flow rate and strict water quality manage…
View article: Neutrophil Gelatinase-Associated Lipocalin: Biological Aspects and Potential Diagnostic Use in Acute Kidney Injury
Neutrophil Gelatinase-Associated Lipocalin: Biological Aspects and Potential Diagnostic Use in Acute Kidney Injury Open
Acute kidney injury (AKI) is a syndrome characterized by a rise in creatinine or a decrease in urinary flow, according to the Kidney Disease Improving Global Outcomes (KDIGO) definition. It is diagnosed in 15% of inpatients and 50% of pati…
View article: Assessment of Safety and Efficacy of Expanded Hemodialysis with Medium Cut-Off Dialyzer Compared to Hemodiafiltration
Assessment of Safety and Efficacy of Expanded Hemodialysis with Medium Cut-Off Dialyzer Compared to Hemodiafiltration Open
Background: Removal of large uraemic toxins is still a challenge. HDF has produced some results although large convective volume, optimal vascular access to increase the blood flow rate and strict water quality management are required. Med…