Claudio Bellevicine
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View article: Artificial Intelligence in Thyroid Cytopathology: Diagnostic and Technical Insights
Artificial Intelligence in Thyroid Cytopathology: Diagnostic and Technical Insights Open
Fine-needle aspiration cytology (FNAC) is the cornerstone of thyroid nodule evaluation, standardized by the Bethesda System. However, indeterminate categories (Bethesda III–IV) remain a major challenge, often leading to unnecessary surgery…
View article: Environmental and lifestyle factors and risk of thyroid carcinoma: a cross-sectional study
Environmental and lifestyle factors and risk of thyroid carcinoma: a cross-sectional study Open
View article: Environmental and lifestyle factors and risk of thyroid carcinoma: a cross- sectional study
Environmental and lifestyle factors and risk of thyroid carcinoma: a cross- sectional study Open
Purpose: The incidence of differentiated thyroid carcinoma (DTC) is increasing, and environmental factors, including lifestyle and endocrine-disrupting chemicals (EDCs) exposure, have been advocated as having an etiologic role. To investig…
View article: The Interconnection Between UbcH10, p53, and EGFR in Lung Cancer Cells and Their Involvement in Treatment Response
The Interconnection Between UbcH10, p53, and EGFR in Lung Cancer Cells and Their Involvement in Treatment Response Open
Background/Objectives: The UbcH10 protein plays an important role in a variety of human malignancies, including thyroid, breast, ovarian, and colorectal carcinomas. It has been previously reported that UbcH10 is overexpressed in non-small …
View article: InterobServer AgreeMent in Pd‐l1 evaLuatIoN on cytoloGical samples—SAMPLING project: A multi‐institutional, international study
InterobServer AgreeMent in Pd‐l1 evaLuatIoN on cytoloGical samples—SAMPLING project: A multi‐institutional, international study Open
Introduction The aim of this project is to assess interobserver agreement for programmed death‐ligand 1 (PD‐L1) scoring on of non–small cell lung cancer (NSCLC) on cytological specimens in a large‐scale multicenter study, by exploiting the…
View article: Interventional cytopathologist perspective on the Milan System Classification: a study on 929 consecutive salivary gland fine-needle aspirations with a focus on challenging diagnostic categories
Interventional cytopathologist perspective on the Milan System Classification: a study on 929 consecutive salivary gland fine-needle aspirations with a focus on challenging diagnostic categories Open
Interventional cytopathologists play an important role in salivary gland cytopathology, as demonstrated by the overt concordance between our ROM rates and those recommended by the MSRSGC.
View article: Navigating the Diagnostic Challenges in Lymph Node Cytology: The Case of Reactive Hyperplasia
Navigating the Diagnostic Challenges in Lymph Node Cytology: The Case of Reactive Hyperplasia Open
Fine needle cytology (FNC) is a pivotal diagnostic tool for distinguishing between benign and malignant lymphadenopathies mainly because of its minimal invasiveness, cost‐effectiveness and accuracy. A major requirement for maximising diagn…
View article: RNA-Based Next-Generation Sequencing in Non-Small Cell Lung Cancer patients: data from Campania, Italy
RNA-Based Next-Generation Sequencing in Non-Small Cell Lung Cancer patients: data from Campania, Italy Open
In this study, we provide real-world experience on RNA-based NGS analysis in patients with advanced stage NSCLC.
View article: Editorial: Molecular characterization of thyroid lesions in the era of “next generation” techniques: volume II
Editorial: Molecular characterization of thyroid lesions in the era of “next generation” techniques: volume II Open
Editorial: Molecular characterization of thyroid lesions in the era of "next generation" techniques: volume II
View article: How Molecular and Ancillary Tests Can Help in Challenging Cytopathology Cases: Insights from the International Molecular Cytopathology Meeting
How Molecular and Ancillary Tests Can Help in Challenging Cytopathology Cases: Insights from the International Molecular Cytopathology Meeting Open
Over the past decade, molecular cytopathology has emerged as a relevant area of modern pathology. Notably, in patients with advanced-stage cancer, cytological samples could be the only material available for diagnosis and molecular biomark…
View article: A case of Kennedy terminal ulcer in a 17th-century Italian mummy
A case of Kennedy terminal ulcer in a 17th-century Italian mummy Open
Giacomo Torno was born in 1539 (or 1541) in Naples. At the age of 18 he joined the Clerics Regular Theatines in San Paolo Maggiore and was welcomed on 30 October 1558. He suffered a stroke on 4 December 1608 and died 45 days later. Contemp…
View article: Molecular testing in salivary gland cytopathology: A practical overview in conjunction with the Milan system
Molecular testing in salivary gland cytopathology: A practical overview in conjunction with the Milan system Open
Recently, significant advances in the molecular characterization of salivary gland neoplasms have facilitated the classification and diagnosis of specific diagnostic entities. In the highly challenging diagnostic scenario of salivary malig…
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View article: Evaluating local thyroid cytopathology practices by molecular quality metrics: A multi‐institutional study on 4651 FNAs with a focus on the role of the interventional cytopathologist
Evaluating local thyroid cytopathology practices by molecular quality metrics: A multi‐institutional study on 4651 FNAs with a focus on the role of the interventional cytopathologist Open
Background The diagnostic accuracy of thyroid fine‐needle aspiration (FNA) can be highly influenced by the technical skills of the operator performing the procedure and by interobserver variability in microscopic interpretation. This is pa…
View article: Delphi expert consensus for whole slide imaging in thyroid cytopathology
Delphi expert consensus for whole slide imaging in thyroid cytopathology Open
Objective Despite an increase in thyroid fine needle aspiration (FNA) and advances in whole slide imaging (WSI) adoption, digital pathology is still considered inadequate for primary diagnosis of these cases. Herein, we aim to validate the…
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View article: Supplemental Figure 3 from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer
Supplemental Figure 3 from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer Open
Graphycal representation of the interplay between Hedgehog and MET pathway.
View article: Supplemental Table 2 from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer
Supplemental Table 2 from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer Open
Intensity score , percentage score and IHC score of Vimentina, MET and PTCH on tumor xenografts in nude mice collected at the end of treatment.
View article: Supplemental Table 2 from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer
Supplemental Table 2 from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer Open
Intensity score , percentage score and IHC score of Vimentina, MET and PTCH on tumor xenografts in nude mice collected at the end of treatment.
View article: Supplemental Figure 3 from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer
Supplemental Figure 3 from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer Open
Graphycal representation of the interplay between Hedgehog and MET pathway.
View article: Supplemental Figure 2 from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer
Supplemental Figure 2 from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer Open
A) GLI1 promoter activity in EGFR-WT NSCLC cell lines. Effects of Hh and EGFR inhibition in EGFR-WT NSCLC cell lines on their abilities to B) growth, C) invade , D)migrate and E) colony forming. F)In vivo efficacy of erlotinib and LDE225 o…
View article: Supplemental Table 1 from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer
Supplemental Table 1 from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer Open
EGFR mutational status, gefitinib sensitivity and HH pathway activation in our panel of NSCLC cell lines.
View article: Supplemental Materials and Methods from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer
Supplemental Materials and Methods from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer Open
Supplemental matherial and methods