Explanipedia

Author response: Region-specific mechanosensation controls Drosophila postural control behaviour Open

William Roseby, Jonathan A. C. Menzies, Victoria A Lipscomb, Claudio R. Alonso · 2025

Region-specific mechanosensation controls Drosophila postural control behaviour Open

William Roseby, Jonathan A. C. Menzies, Victoria A Lipscomb, Claudio R. Alonso · 2025

The relation between regional morphological features derived from the bilaterian body plan and the behaviours necessary to extract utility from such structures is not well understood. Here we use the Drosophila larva to investigate this ‘f…

Region-specific mechanosensation controls Drosophila postural control behaviour Open

William Roseby, Jonathan A. C. Menzies, Victoria A Lipscomb, Claudio R. Alonso · 2025

The relation between regional morphological features derived from the bilaterian body plan and the behaviours necessary to extract utility from such structures is not well understood. Here we use the Drosophila larva to investigate this ‘f…

Region-specific mechanosensation controls Drosophila postural control behaviour Open

William Roseby, Jonathan A. C. Menzies, Victoria A Lipscomb, Claudio R. Alonso · 2025

The relation between regional morphological features derived from the bilaterian body plan and the behaviours necessary to extract utility from such structures is not well understood. Here we use the Drosophila larva to investigate this ‘f…

A microRNA that controls the emergence of embryonic movement Open

Jonathan A. C. Menzies, André Maia Chagas, Tom Baden, Claudio R. Alonso · 2024

Movement is a key feature of animal systems, yet its embryonic origins are not fully understood. Here, we investigate the genetic basis underlying the embryonic onset of movement in Drosophila focusing on the role played by small non-codin…

Author response: A microRNA that controls the emergence of embryonic movement Open

Jonathan A. C. Menzies, André Maia Chagas, Tom Baden, Claudio R. Alonso · 2024

Reviewer #2 (Public Review): A microRNA that controls the emergence of embryonic movement Open

Jonathan A. C. Menzies, André Maia Chagas, Tom Baden, Claudio R. Alonso · 2024

Movement is a key feature of animal systems, yet its embryonic origins are not fully understood. Here we investigate the genetic basis underlying the embryonic onset of movement in Drosophila focusing on the role played by small non-coding…

Reviewer #1 (Public Review): A microRNA that controls the emergence of embryonic movement Open

Jonathan A. C. Menzies, André Maia Chagas, Tom Baden, Claudio R. Alonso · 2024

Movement is a key feature of animal systems, yet its embryonic origins are not fully understood. Here we investigate the genetic basis underlying the embryonic onset of movement in Drosophila focusing on the role played by small non-coding…

Author response: A microRNA that controls the emergence of embryonic movement Open

Jonathan A. C. Menzies, André Maia Chagas, Tom Baden, Claudio R. Alonso · 2024

Movement is a key feature of animal systems, yet its embryonic origins are not fully understood. Here we investigate the genetic basis underlying the embryonic onset of movement in Drosophila focusing on the role played by small non-coding…

A microRNA that controls the emergence of embryonic movement Open

Jonathan A. C. Menzies, André Maia Chagas, Tom Baden, Claudio R. Alonso · 2024

Summary Movement is a key feature of animal systems, yet its embryonic origins are not fully understood. Here we investigate the genetic basis underlying the embryonic onset of movement in Drosophila focusing on the role played by small no…

A microRNA that controls the emergence of embryonic movement Open

Jonathan A. C. Menzies, André Maia Chagas, Tom Baden, Claudio R. Alonso · 2024

Movement is a key feature of animal systems, yet its embryonic origins are not fully understood. Here, we investigate the genetic basis underlying the embryonic onset of movement in Drosophila focusing on the role played by small non-codin…

A microRNA that controls the emergence of embryonic movement Open

Jonathan A. C. Menzies, André Maia Chagas, Claudio R. Alonso · 2024

Summary Movement is a key feature of animal systems, yet its embryonic origins are not fully understood. Here we investigate the genetic basis underlying the embryonic onset of movement in Drosophila focusing on the role played by small no…

Author Response: A microRNA that controls the emergence of embryonic movement Open

Jonathan A. C. Menzies, André Maia Chagas, Claudio R. Alonso · 2024

Movement is a key feature of animal systems, yet its embryonic origins are not fully understood. Here we investigate the genetic basis underlying the embryonic onset of movement in Drosophila focusing on the role played by small non-coding…

A microRNA that controls the emergence of embryonic movement Open

Jonathan A. C. Menzies, André Maia Chagas, Tom Baden, Claudio R. Alonso · 2024

SUMMARY Movement is a key feature of animal systems, yet its embryonic origins are not fully understood. Here we investigate the genetic basis underlying the embryonic onset of movement in Drosophila focusing on the role played by small no…

A novel post-developmental role of the Hox genes underlies normal adult behavior Open

Abdul-Raouf Issa, Jonathan A. C. Menzies, Aishwarya Padmanabhan, Claudio R. Alonso · 2022

The molecular mechanisms underlying the stability of mature neurons and neural circuits are poorly understood. Here we explore this problem and discover that the Hox genes are a component of the genetic program that maintains normal neural…

Supplemental Data and Code for "A physical theory of movement in small animals" Open

Jane Loveless, Alastair Garner, Abdul-Raouf Issa, Ruairí J.V. Roberts, Barbara Webb , et al. · 2021

Supplemental Data and Code for "A physical theory of movement in small animals" This manuscript is currently a preprint, available on biorxiv: https://doi.org/10.1101/2020.08.25.266163

A novel post-developmental role of the Hox genes underlies normal adult behaviour Open

Abdul-Raouf Issa, Claudio R. Alonso · 2021

The molecular mechanisms underlying the stability of mature neurons and neural circuits are poorly understood. Here we explore this problem and discover that the Hox genes are a component of the genetic programme that maintains normal neur…

MicroRNA-Dependent Control of Sensory Neuron Function Regulates Posture Behavior in Drosophila Open

Marleen Klann, Abdul-Raouf Issa, Sofia Pinho, Claudio R. Alonso · 2021

All what we see, touch, hear, taste, or smell must first be detected by the sensory elements of our nervous system. Sensory neurons, therefore, represent a critical component in all neural circuits and their correct function is essential f…

A physical theory of movement in small animals Open

Jane Loveless, Alastair Garner, Abdul-Raouf Issa, Ruairí J.V. Roberts, Barbara Webb , et al. · 2020

All animal behaviour must ultimately be governed by physical laws. As a basis for understanding the physics of behaviour in a simple system, we here develop an effective theory for the motion of the larval form of the fruitfly Drosophila m…

microRNA-dependent control of sensory neuron function regulates posture behaviour inDrosophila Open

Marleen Klann, Abdul-Raouf Issa, Claudio R. Alonso · 2020

All what we see, touch, hear, taste or smell must first be detected by the sensory elements in our nervous system. Sensory neurons, therefore, represent a critical component in all neural circuits and their correct function is essential fo…

A Single MicroRNA-Hox Gene Module Controls Equivalent Movements in Biomechanically Distinct Forms of Drosophila Open

Abdul-Raouf Issa, João Picão-Osório, Nuno Rito, M Eugenia Chiappe, Claudio R. Alonso · 2019

A single microRNA-Hox gene module controls complex movement in morphologically-distinct developmental forms ofDrosophila Open

AR. Issa, João Picão-Osório, Nuno Rito, M Eugenia Chiappe, Claudio R. Alonso · 2019

Movement is the main output of the nervous system. It emerges during development to become a highly coordinated physiological process essential to the survival and adaptation of the organism to the environment. Similar movements can be obs…

MicroRNA-dependent regulation of Hox gene expression sculpts fine-grain morphological patterns in a Drosophila appendage Open

Richard Kaschula, Sofia Pinho, Claudio R. Alonso · 2018

Disruptions of normal Hox gene expression can lead to severe morphological defects, revealing a link between the regulation of Hox expression and pattern formation. Here, we explore these links, focusing on the impact of microRNA regulatio…

Issue Information Open

Ingo Braasch, John H. Postlethwait, Edmund Wilson, Thomas Morgan, George Parker , et al. · 2017

Pervasive Behavioral Effects of MicroRNA Regulation inDrosophila Open

João Picão-Osório, Inês Lago‐Baldaia, Pedro Patraquim, Claudio R. Alonso · 2017

Picao-Osorio et al. reveal pervasive effects of microRNA regulation on complex locomotor behaviors in Drosophila larvae: over 40% of microRNAs display... The effects of microRNA (miRNA) regulation on the genetic programs underlying behavio…

Molecular Regulation of Alternative Polyadenylation (APA) within the Drosophila Nervous System Open

Raúl Vallejos Baier, João Picão-Osório, Claudio R. Alonso · 2017

Combinatorial Gene Regulatory Functions Underlie Ultraconserved Elements in Drosophila Open

Maria Warnefors, Britta Hartmann, Stefan Thomsen, Claudio R. Alonso · 2016

Ultraconserved elements (UCEs) are discrete genomic elements conserved across large evolutionary distances. Although UCEs have been linked to multiple facets of mammalian gene regulation their extreme evolutionary conservation remains larg…

MicroRNA-encoded behavior in Drosophila Open

João Picão-Osório, Jamie Johnston, Matthias Landgraf, Jimena Berni, Claudio R. Alonso · 2015

The relationship between microRNA (miRNA) regulation and the specification of behavior is only beginning to be explored. We found that mutation of a single miRNA locus ( miR-iab4/iab8 ) in Drosophila larvae affects the animal’s capacity to…

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