Claudio Saccu
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View article: Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts
Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts Open
Background Bypass surgery using saphenous vein (SV) grafts is commonly performed to revascularize the ischemic heart and lower limbs. These interventions have limited success due to adverse remodeling caused by overproliferation of smooth …
View article: Deciphering Abdominal Aortic Diseases Through T‐Cell Clonal Repertoire of Perivascular Adipose Tissue
Deciphering Abdominal Aortic Diseases Through T‐Cell Clonal Repertoire of Perivascular Adipose Tissue Open
Background Recent studies suggest that immune‐mediated inflammation of perivascular adipose tissue of abdominal aortic aneurysms (AAAs) contributes to disease development and progression. Whether the perivascular adipose tissue of AAA is c…
View article: Deciphering abdominal aortic diseases through T-cell clonal repertoire of perivascular adipose tissue
Deciphering abdominal aortic diseases through T-cell clonal repertoire of perivascular adipose tissue Open
Recent studies suggested that immune-mediated inflammation of perivascular adipose tissue (PVAT) of abdominal aortic aneurysms (AAA) contributes to disease development and progression. Whether the PVAT of AAA is characterized by a specific…
View article: Aortic valve sclerosis as an important predictor of long-term mortality in patients with carotid atheromatous plaque requiring carotid endarterectomy
Aortic valve sclerosis as an important predictor of long-term mortality in patients with carotid atheromatous plaque requiring carotid endarterectomy Open
This record contains raw data related to the article "Aortic valve sclerosis as an important predictor of long-term mortality in patients with carotid atheromatous plaque requiring carotid endarterectomy". A strong association between aort…
View article: Aortic valve sclerosis as an important predictor of long-term mortality in patients with carotid atheromatous plaque requiring carotid endarterectomy
Aortic valve sclerosis as an important predictor of long-term mortality in patients with carotid atheromatous plaque requiring carotid endarterectomy Open
This record contains raw data related to the article "Aortic valve sclerosis as an important predictor of long-term mortality in patients with carotid atheromatous plaque requiring carotid endarterectomy". A strong association between aort…
View article: Aortic Valve Sclerosis as an Important Predictor of Long-Term Mortality in Patients With Carotid Atheromatous Plaque Requiring Carotid Endarterectomy
Aortic Valve Sclerosis as an Important Predictor of Long-Term Mortality in Patients With Carotid Atheromatous Plaque Requiring Carotid Endarterectomy Open
Background: A strong association between aortic valve sclerosis (AVSc), the earliest manifestation of calcific aortic valve disease, and atherosclerosis exists. The aim of the study was to evaluate the predictive capabilities of AVSc on lo…
View article: Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1
Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1 Open
This record contains raw data related to the article "Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1". Rationale: Des…
View article: Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1
Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1 Open
This record contains raw data related to the article "Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1". Rationale: Des…
View article: Gene-expression profiles of abdominal perivascular adipose tissue distinguish aortic occlusive from stenotic atherosclerotic lesions and denote different pathogenetic pathways
Gene-expression profiles of abdominal perivascular adipose tissue distinguish aortic occlusive from stenotic atherosclerotic lesions and denote different pathogenetic pathways Open
View article: Coronary artery mechanics induces human saphenous vein remodelling <i>via</i> recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1
Coronary artery mechanics induces human saphenous vein remodelling <i>via</i> recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1 Open
Rationale: Despite the preferred application of arterial conduits, the greater saphenous vein (SV) remains indispensable for coronary bypass grafting (CABG), especially in multi-vessel coronary artery disease (CAD). The objective of…
View article: P6546Thrombospondin-1 is involved in human saphenous vein graft remodelling in response to coronary hemodynamic conditions
P6546Thrombospondin-1 is involved in human saphenous vein graft remodelling in response to coronary hemodynamic conditions Open
View article: P3771YAP-dependent signalling predisposes pathologic evolution of human saphenous vein progenitors by altered mechano-perception in vein bypass failure
P3771YAP-dependent signalling predisposes pathologic evolution of human saphenous vein progenitors by altered mechano-perception in vein bypass failure Open
Although there was no difference between the two groups, better self-care behavior was reported in the SMS and STS group when compared with the control group (medication compliance, 78.9% vs. 81.4% vs. 69.5%,P=0.011; water restriction, 70.…
View article: miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase)
miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase) Open
Objective— Vascular calcification (VC) is age dependent and a risk factor for cardiovascular and all-cause mortality. VC involves the senescence-induced transdifferentiation of vascular smooth muscle cells (SMCs) toward an osteochondrogeni…