Cláudio N. Soares
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View article: The burden of sleep disturbances and vasomotor symptoms on work productivity, activity impairment and healthcare resource use in perimenopausal and postmenopausal women
The burden of sleep disturbances and vasomotor symptoms on work productivity, activity impairment and healthcare resource use in perimenopausal and postmenopausal women Open
Sleep disturbances and VMS were associated with worse WPAI scores and more healthcare visits in postmenopausal women, indicating a need for effective management of these symptoms among this population.
View article: Ketamine, Psychedelics, and Psychotherapy: Reframing, Redefining, Renaming Treatment Models
Ketamine, Psychedelics, and Psychotherapy: Reframing, Redefining, Renaming Treatment Models Open
There has been a renewed interest in the use of various psychedelic agents as potential therapies for multiple psychiatric conditions, including post-traumatic stress disorder (PTSD), major depressive disorder (MDD), generalized anxiety di…
View article: Socioeconomic status is associated with reward processing, interleukin 1β, striatal connectivity and antidepressant outcomes in individuals with major depressive disorder: A CAN-BIND-1 report.
Socioeconomic status is associated with reward processing, interleukin 1β, striatal connectivity and antidepressant outcomes in individuals with major depressive disorder: A CAN-BIND-1 report. Open
View article: Elinzanetant for the Treatment of Vasomotor Symptoms Associated With Menopause
Elinzanetant for the Treatment of Vasomotor Symptoms Associated With Menopause Open
Importance There is an unmet need for long-term, safe, effective, and hormone-free treatments for menopausal symptoms, including vasomotor symptoms (VMS) and sleep disturbances. Objective To evaluate the 52-week efficacy and safety of elin…
View article: Standardized EEG for multi-site biomarker-informed trials: Implementation in the Canadian Biomarker Integration Network in Depression
Standardized EEG for multi-site biomarker-informed trials: Implementation in the Canadian Biomarker Integration Network in Depression Open
Our study offers comprehensive solutions for EEG practices across multiple sites, providing valuable insights and inspiration for establishing standardization approaches in collaborative neuroimaging efforts beyond depression research.
View article: A framework to assess risks for non-medical use of psychedelics: The liability for abuse of psychedelics questionnaire (LAPQ)
A framework to assess risks for non-medical use of psychedelics: The liability for abuse of psychedelics questionnaire (LAPQ) Open
As psychedelic research moves forward, trial design could benefit from assessments of potential risks of treatment. One such risk is future abuse or misuse of the drug or other drugs of abuse. Like the ketamine literature, psychedelic stud…
View article: Perceptions and insights: A qualitative assessment of an AI-assisted psychiatric triage system implemented in an outpatient hospital setting
Perceptions and insights: A qualitative assessment of an AI-assisted psychiatric triage system implemented in an outpatient hospital setting Open
Introduction The Canadian healthcare system is approaching a breaking point. With mental health being a leading cause of disability, innovative solutions are necessary to provide adequate care. Digital mental health programs, such as elect…
View article: Correction: Replication of machine learning methods to predict treatment outcome with antidepressant medications in patients with major depressive disorder from STAR*D and CAN-BIND-1
Correction: Replication of machine learning methods to predict treatment outcome with antidepressant medications in patients with major depressive disorder from STAR*D and CAN-BIND-1 Open
[This corrects the article DOI: 10.1371/journal.pone.0253023.].
View article: Modulation of neural oscillations in escitalopram treatment: a Canadian biomarker integration network in depression study
Modulation of neural oscillations in escitalopram treatment: a Canadian biomarker integration network in depression study Open
View article: Elinzanetant for the Treatment of Vasomotor Symptoms Associated With Menopause
Elinzanetant for the Treatment of Vasomotor Symptoms Associated With Menopause Open
Importance Safe and effective nonhormonal treatments for menopausal vasomotor symptoms (VMS) are needed. Objective To evaluate the efficacy and safety of elinzanetant, a selective neurokinin-1,3 receptor antagonist, for the treatment of mo…
View article: Canadian Network for Mood and Anxiety Treatments (CANMAT) 2023 Update on Clinical Guidelines for Management of Major Depressive Disorder in Adults: Réseau canadien pour les traitements de l'humeur et de l'anxiété (CANMAT) 2023 : Mise à jour des lignes directrices cliniques pour la prise en charge du trouble dépressif majeur chez les adultes
Canadian Network for Mood and Anxiety Treatments (CANMAT) 2023 Update on Clinical Guidelines for Management of Major Depressive Disorder in Adults: Réseau canadien pour les traitements de l'humeur et de l'anxiété (CANMAT) 2023 : Mise à jour des lignes directrices cliniques pour la prise en charge du trouble dépressif majeur chez les adultes Open
Background The Canadian Network for Mood and Anxiety Treatments (CANMAT) last published clinical guidelines for the management of major depressive disorder (MDD) in 2016. Owing to advances in the field, an update was needed to incorporate …
View article: A body beaten again: a narrative analysis of a series of cases of breast cancer survivors punctuated by violence
A body beaten again: a narrative analysis of a series of cases of breast cancer survivors punctuated by violence Open
Introduction Various mechanisms have been identified to explain the relationship between gender-based violence, screening, and cancer. Biological mechanisms, primarily related to chronic stress and allostatic load, have been associated wit…
View article: Large Individual Differences in Functional Connectivity in the Context of Major Depression and Antidepressant Pharmacotherapy
Large Individual Differences in Functional Connectivity in the Context of Major Depression and Antidepressant Pharmacotherapy Open
Clinical studies of major depression (MD) often examine differences between groups whilst ignoring within-group variation. However, inter-individual differences in brain function are increasingly recognised as important and may impact effe…
View article: Developing an Electroencephalography-Based Model for Predicting Response to Antidepressant Medication
Developing an Electroencephalography-Based Model for Predicting Response to Antidepressant Medication Open
Importance Untreated depression is a growing public health concern, with patients often facing a prolonged trial-and-error process in search of effective treatment. Developing a predictive model for treatment response in clinical practice …
View article: A standardized workflow for long-term longitudinal actigraphy data processing using one year of continuous actigraphy from the CAN-BIND Wellness Monitoring Study
A standardized workflow for long-term longitudinal actigraphy data processing using one year of continuous actigraphy from the CAN-BIND Wellness Monitoring Study Open
Monitoring sleep and activity through wearable devices such as wrist-worn actigraphs has the potential for long-term measurement in the individual’s own environment. Long periods of data collection require a complex approach, including sta…
View article: SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants
SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants Open
Pharmacotherapies for the treatment of major depressive disorder were serendipitously discovered almost seven decades ago. From this discovery, scientists pinpointed the monoaminergic system as the primary target associated with symptom al…
View article: Author response: SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants
Author response: SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants Open
View article: Resting-state EEG delta and alpha power predict response to cognitive behavioral therapy in depression: a Canadian biomarker integration network for depression study
Resting-state EEG delta and alpha power predict response to cognitive behavioral therapy in depression: a Canadian biomarker integration network for depression study Open
Cognitive behavioral therapy (CBT) is often recommended as a first-line treatment in depression. However, access to CBT remains limited, and up to 50% of patients do not benefit from this therapy. Identifying biomarkers that can predict wh…
View article: Evaluating the Efficacy of Web-Based Cognitive Behavioral Therapy for the Treatment of Patients With Bipolar II Disorder and Residual Depressive Symptoms: Protocol for a Randomized Controlled Trial
Evaluating the Efficacy of Web-Based Cognitive Behavioral Therapy for the Treatment of Patients With Bipolar II Disorder and Residual Depressive Symptoms: Protocol for a Randomized Controlled Trial Open
Background Bipolar disorder (BD) is a highly prevalent psychiatric condition that can significantly impact every aspect of a person’s life if left untreated. A subtype of BD, bipolar disorder type II (BD-II), is characterized by long depre…
View article: Mental health challenges, treatment experiences, and care needs of post-secondary students: a cross-sectional mixed-methods study
Mental health challenges, treatment experiences, and care needs of post-secondary students: a cross-sectional mixed-methods study Open
Background Post-secondary students frequently experience high rates of mental health challenges. However, they present meagre rates of treatment-seeking behaviours. This elevated prevalence of mental health problems, particularly after the…
View article: Efficacious Web-Based Psychotherapy to Address Depression and Anxiety Among Patients Receiving Oncological and Palliative Care: an Open-Label Randomised Controlled Trial
Efficacious Web-Based Psychotherapy to Address Depression and Anxiety Among Patients Receiving Oncological and Palliative Care: an Open-Label Randomised Controlled Trial Open
Introduction Oncological and palliative care patients face unique stressors which increase their risk of developing depression and anxiety. Cognitive behavioural therapy (CBT) and mindfulness has established success in improving this popul…
View article: Evaluating the Efficacy of Web-Based Cognitive Behavioral Therapy for the Treatment of Patients With Bipolar II Disorder and Residual Depressive Symptoms: Protocol for a Randomized Controlled Trial (Preprint)
Evaluating the Efficacy of Web-Based Cognitive Behavioral Therapy for the Treatment of Patients With Bipolar II Disorder and Residual Depressive Symptoms: Protocol for a Randomized Controlled Trial (Preprint) Open
BACKGROUND Bipolar disorder (BD) is a highly prevalent psychiatric condition that can significantly impact every aspect of a person’s life if left untreated. A subtype of BD, bipolar disorder type II (BD-II), is characterized by long depr…
View article: <scp><i>ABCB1</i></scp> Gene Variants and Antidepressant Treatment Outcomes: A Systematic Review and Meta‐Analysis Including Results from the <scp>CAN‐BIND</scp>‐1 Study
<span><i>ABCB1</i></span> Gene Variants and Antidepressant Treatment Outcomes: A Systematic Review and Meta‐Analysis Including Results from the <span>CAN‐BIND</span>‐1 Study Open
The P‐glycoprotein efflux pump, encoded by the ABCB1 gene, has been shown to alter concentrations of various antidepressants in the brain. In this study, we conducted a systematic review and meta‐analysis to investigate the association bet…
View article: A standardized workflow for long-term longitudinal actigraphy data processing: One year of continuous actigraphy from the CAN-BIND Wellness Monitoring Study
A standardized workflow for long-term longitudinal actigraphy data processing: One year of continuous actigraphy from the CAN-BIND Wellness Monitoring Study Open
Monitoring sleep and activity through wearable devices such as wrist-worn actigraphs has the potential for long-term measurement in the individual’s own environment. Long periods of data collection require a complex approach, including sta…
View article: Additional file 2 of Mental health challenges, treatment experiences, and care needs of post-secondary students: a cross-sectional mixed-methods study
Additional file 2 of Mental health challenges, treatment experiences, and care needs of post-secondary students: a cross-sectional mixed-methods study Open
Additional file 2: Appendix 2. Perceived helpfulness and accessibility of treatments in survey respondents currently receiving psychotherapy/counseling and medication for their mental health.
View article: Mental health challenges, treatment experiences, and care needs of post-secondary students: a cross-sectional mixed-methods study
Mental health challenges, treatment experiences, and care needs of post-secondary students: a cross-sectional mixed-methods study Open
Background: Post-secondary students are at a greater risk of developing mental health problems than the general population. However, they present meagre rates of treatment-seeking behaviours. This elevated prevalence of mental health probl…
View article: Effects of CYP2C19 and CYP2D6 gene variants on escitalopram and aripiprazole treatment outcome and serum levels: results from the CAN-BIND 1 study
Effects of CYP2C19 and CYP2D6 gene variants on escitalopram and aripiprazole treatment outcome and serum levels: results from the CAN-BIND 1 study Open
Cytochrome P450 drug-metabolizing enzymes may contribute to interindividual differences in antidepressant outcomes. We investigated the effects of CYP2C19 and CYP2D6 gene variants on response, tolerability, and serum concentrations. Patien…
View article: Acute and chronic stress predict anti-depressant treatment outcome and naturalistic course of major depression: A CAN-BIND report
Acute and chronic stress predict anti-depressant treatment outcome and naturalistic course of major depression: A CAN-BIND report Open
Exposure to minor events may provide an opportunity to practice problem-solving skills, thereby facilitating symptom improvement. Nevertheless, acute treatment did not protect patients from relapse when they subsequently faced major events…
View article: Early optimized pharmacological treatment in patients with depression and chronic pain
Early optimized pharmacological treatment in patients with depression and chronic pain Open
Major depressive disorder (MDD) is the leading cause of disability worldwide. Patients with MDD have high rates of comorbidity with mental and physical conditions, one of which is chronic pain. Chronic pain conditions themselves are also a…
View article: Common Data Elements to Facilitate Sharing and Re-use of Participant-Level Data: Assessment of Psychiatric Comorbidity Across Brain Disorders
Common Data Elements to Facilitate Sharing and Re-use of Participant-Level Data: Assessment of Psychiatric Comorbidity Across Brain Disorders Open
The Ontario Brain Institute's “Brain-CODE” is a large-scale informatics platform designed to support the collection, storage and integration of diverse types of data across several brain disorders as a means to understand underlying causes…