Claus Cornett
YOU?
Author Swipe
View article: Visualization and quantification of citalopram hydrobromide within highly porous drug products by near-infrared chemical imaging
Visualization and quantification of citalopram hydrobromide within highly porous drug products by near-infrared chemical imaging Open
A novel method for the fabrication of flexible and precise doses of an antidepressant, citalopram hydrobromide (CHB), utilizing two approaches of incorporating CHB into the dosage form, was introduced in an earlier study. This method, call…
View article: Understanding the complexity of near-infrared quantification of highly porous patient-tailored drug products by utilizing chemometrics and stimulated Raman imaging
Understanding the complexity of near-infrared quantification of highly porous patient-tailored drug products by utilizing chemometrics and stimulated Raman imaging Open
Additively manufactured drug products, typically produced using small-scale, on-demand batch mode, require rapid and non-destructive quantification methods. A tunable modular design (TMD) approach combining porous polymeric freeze-dried mo…
View article: Tailor‐Made Doses of Pharmaceuticals by Tunable Modular Design: A Case Study on Tapering Antidepressant Medication
Tailor‐Made Doses of Pharmaceuticals by Tunable Modular Design: A Case Study on Tapering Antidepressant Medication Open
An abrupt cessation of antidepressant medication can be challenging due to the appearance of withdrawal symptoms. A slow hyperbolic tapering of an antidepressant, such as citalopram hydrobromide (CHB), can mitigate the withdrawal syndrome.…
View article: Isolation and elucidation of antibacterial compounds from roots and stems of Synadenium glaucescens Pax
Isolation and elucidation of antibacterial compounds from roots and stems of Synadenium glaucescens Pax Open
Extracts of Synadenium glaucescens Pax are reported to contain biologically active compounds against bacterial and viral infections. This study aimed at isolating pure compounds from its bioactive extracts as well as evaluating their antib…
View article: Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn’t
Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn’t Open
The ‘entourage effect’ term was originally coined in a pre-clinical study observing endogenous bio-inactive metabolites potentiating the activity of a bioactive endocannabinoid. As a hypothetical afterthought, this was proposed to hold gen…
View article: Clinical Research Evidence Supporting Administration and Dosing Recommendations of Medicinal Cannabis as Analgesic in Cancer Patients
Clinical Research Evidence Supporting Administration and Dosing Recommendations of Medicinal Cannabis as Analgesic in Cancer Patients Open
The analgesic potential of Cannabis sativa L.—based medicinal cannabis products for treatment of cancer associated chronic pains has gained increased interest in recent years. To ensure a controlled distribution of these products and inves…
View article: The concentration of lidocaine and mepivacaine measured in synovial fluid of different joints of horses after single intra-articular injection
The concentration of lidocaine and mepivacaine measured in synovial fluid of different joints of horses after single intra-articular injection Open
Objective To determine the synovial fluid (SF) concentrations of lidocaine and mepivacaine after intra-articular injection with clinically relevant doses to the distal interphalangeal (DIP), metacarpophalangeal (MCP), middle carpal (MC), a…
View article: Activity of Sterols Isolated from the Leaves of Commiphora swynnertonii (Burtt) Against Some Nosocomial Infectious Bacteria
Activity of Sterols Isolated from the Leaves of Commiphora swynnertonii (Burtt) Against Some Nosocomial Infectious Bacteria Open
Commiphora swynnertonii (Burtt) is traditionally used for medicinal purposes both in humans and animals in Tanzania. Previously, its leaves extract has been demonstrated antibacterial activity. However, there is limited information on iden…
View article: Isolation and toxicity evaluation of feruloyl ester and other triterpenoids from Synadenium glaucescens Pax
Isolation and toxicity evaluation of feruloyl ester and other triterpenoids from Synadenium glaucescens Pax Open
The use of plants as sources of drug agents is attributed by factors among which are the easy accessibility to plants, less toxicity and little or no drug resistance. An improvement in both traditional medicine and drug discovery field nec…
View article: Isolation and Cytotoxicity Evaluation of Long Chain Bioactive Compounds from Commiphora swynnertonii (Burtt)
Isolation and Cytotoxicity Evaluation of Long Chain Bioactive Compounds from Commiphora swynnertonii (Burtt) Open
Commiphora swynnertonii (Burtt) is a medicinal plant with diverse traditional uses in Tanzania. However, there is limited information on isolation and cytotoxicity properties of bioactive compounds responsible for its pharmacological activ…
View article: Structural Elucidation and Toxicity Evaluation of Bioactive Compounds from the Leaves and Stem woods of Synadenium glaucescens Pax.
Structural Elucidation and Toxicity Evaluation of Bioactive Compounds from the Leaves and Stem woods of Synadenium glaucescens Pax. Open
The leaves and stem woods of Synadenium glaucescens Pax. are traditionally used for treatment of various human diseases in Tanzania. However, there is limited information on the structural elucidation and toxicity properties of bioactive c…
View article: Biological parameters in a declining population of narwhals (<i>Monodon monoceros</i>) in Scoresby Sound, Southeast Greenland
Biological parameters in a declining population of narwhals (<i>Monodon monoceros</i>) in Scoresby Sound, Southeast Greenland Open
A decreasing trend in narwhal (Monodon monoceros Linnaeus, 1758) abundance has been identified in a small population in Scoresby Sound, Southeast Greenland. We hypothesize that excessive hunting has affected life history and population dyn…
View article: Data-Enriched Edible Pharmaceuticals (DEEP) with Bespoke Design, Dose and Drug Release
Data-Enriched Edible Pharmaceuticals (DEEP) with Bespoke Design, Dose and Drug Release Open
Data-enriched edible pharmaceuticals (DEEP) is an approach to obtain personalized medicine, in terms of flexible and precise drug doses, while at the same time containing data, embedded in quick response (QR) codes at a single dosage unit …
View article: Phylogeny Predicts the Quantity of Antimalarial Alkaloids within the Iconic Yellow Cinchona Bark (Rubiaceae: Cinchona calisaya)
Phylogeny Predicts the Quantity of Antimalarial Alkaloids within the Iconic Yellow Cinchona Bark (Rubiaceae: Cinchona calisaya) Open
Considerable inter- and intraspecific variation with respect to the quantity and composition of plant natural products exists. The processes that drive this variation remain largely unknown. Understanding which factors determine chemical d…
View article: Quantification of pharmaceutical peptides in human plasma by LC-ICP-MS sulfur detection
Quantification of pharmaceutical peptides in human plasma by LC-ICP-MS sulfur detection Open
Quantification of pharmaceutical peptides in human plasma by RP-LC-ICP-MS and post column isotope dilution.